Results 91 to 100 of about 323,138 (302)

Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]

, 2017
Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef, De Vos, Filip, Devisscher, Lindsey, Kersemans, Ken, Neyt, Sara, Van Vlierberghe, Hans, Vanhove, Christian, Verhoeven, Jeroen   +7 more
core   +3 more sources

Preservation of conjugated primary bile acids by oxygenation of the small intestinal microbiota in vitro

mBio
Bile acids play a critical role in the emulsification of dietary lipids, a critical step in the primary function of the small intestine, which is the digestion and absorption of food.
Jenni Firrman, Elliot S. Friedman, Aaron Hecht, William C. Strange, Adrienne B. Narrowe, Karley Mahalak, Gary D. Wu, LinShu Liu   +7 more
doaj   +1 more source

Metagenomic analysis of bile salt biotransformation in the human gut microbiome

BMC Genomics, 2019
Background In the biochemical milieu of human colon, bile acids act as signaling mediators between the host and its gut microbiota. Biotransformation of primary to secondary bile acids have been known to be involved in the immune regulation of human ...
Promi Das, Simonas Marcišauskas, Boyang Ji, Jens Nielsen   +3 more
doaj   +1 more source

Critical roles of bile acids in regulating intestinal mucosal immune responses

Therapeutic Advances in Gastroenterology, 2021
Bile acids are a class of cholesterol derivatives that have been known for a long time for their critical roles in facilitating the digestion and absorption of lipid from the daily diet.
Ruicong Sun, Chunjin Xu, Baisui Feng, Xiang Gao, Zhanju Liu   +4 more
doaj   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Hydrogel‐Based Functional Materials: Classifications, Properties, and Applications

Advanced Materials Technologies, EarlyView.
Conductive hydrogels have emerged as promising materials for smart wearable devices due to their outstanding flexibility, multifunctionality, and biocompatibility. This review systematically summarizes recent progress in their design strategies, focusing on monomer systems and conductive components, and highlights key multifunctional properties such as
Zeyu Zhang, Zao Cheng, Patrizio Raffa
wiley   +1 more source

In vitro and in vivo characterization of Clostridium scindens bile acid transformations

Gut Microbes, 2019
The human gut hosts trillions of microorganisms that exert a profound influence on human biology. Gut bacteria communicate with their host by secreting small molecules that can signal to distant organs in the body.
Solenne Marion, Nicolas Studer, Lyne Desharnais, Laure Menin, Stéphane Escrig, Anders Meibom, Siegfried Hapfelmeier, Rizlan Bernier-Latmani   +7 more
doaj   +1 more source

Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity

Metabolites, 2021
Bariatric surgery is the only procedure to obtain and maintain weight loss in the long term, although the mechanisms driving these benefits are not completely understood.
Luis Ocaña-Wilhelmi, Gracia María Martín-Núñez, Patricia Ruiz-Limón, Juan Alcaide, Eduardo García-Fuentes, Carolina Gutiérrez-Repiso, Francisco J. Tinahones, Isabel Moreno-Indias   +7 more
doaj   +1 more source

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism [PDF]

, 2018
C.L.-O. is supported by grants from the European Union (ERC-2016-ADG, DeAge); Ministerio de Economía y Competitividad (MINECO/FEDER: SAF2014-52413-R and SAF2017-87655-R); Instituto de Salud Carlos III (RTICC); Progeria Research Foundation (PRF2016-66 ...
Bárcena Fernández, Clea, Durand, S., Fernández García, María Teresa, Garabaya Fernández, Cecilia, Kroemer, Guido, López Otín, Carlos, Mariño García, Guillermo, Mayoral García, Pablo, Menéndez Caravia, Xurde, Moral Quirós, Pedro, Pérez Freije, José María, Rodríguez, Francisco   +11 more
core   +3 more sources

Deoxycholic Acid, a Secondary Bile Acid, Increases Cardiac Output and Blood Pressure in Rats

Nutrients, 2023
Background: Deoxycholic acid (DCA) is a secondary bile acid produced by gut bacteria. Elevated serum concentrations of DCA are observed in cardiovascular disease (CVD). We hypothesized that DCA might influence hemodynamic parameters in rats. Methods: The concentration of DCA in systemic blood was measured with liquid chromatography coupled with mass ...
Artur Nowiński, Dawid Chabowski, Joanna Giebułtowicz, Marta Aleksandrowicz, Marcin Ufnal   +4 more
openaire   +2 more sources