Results 71 to 80 of about 60,836 (146)

The human gut sterolbiome: bile acid-microbiome endocrine aspects and therapeutics

Acta Pharmaceutica Sinica B, 2015
The human body is now viewed as a complex ecosystem that on a cellular and gene level is mainly prokaryotic. The mammalian liver synthesizes and secretes hydrophilic primary bile acids, some of which enter the colon during the enterohepatic circulation ...
Jason M. Ridlon, Jasmohan S. Bajaj
doaj   +1 more source

Increased dietary protein stimulates amino acid catabolism via the gut microbiota and secondary bile acid production

Gut Microbes
Excess amino acids from a protein-rich diet are mainly catabolized in the liver. However, it is still unclear to what extent the gut microbiota may be involved in the mechanisms governing this catabolism.
Sandra Tobón-Cornejo, Monica Sanchez-Tapia, Rocio Guizar-Heredia, Laura Velázquez Villegas, Lilia G. Noriega, Janette Furuzawa-Carballeda, Rogelio Hernández-Pando, Natalia Vázquez-Manjarrez, Omar Granados-Portillo, Adriana López-Barradas, Rosa Rebollar-Vega, Otoniel Maya, Aaron W. Miller, Aurora Serralde, Martha Guevara-Cruz, Nimbe Torres, Armando R. Tovar   +16 more
doaj   +1 more source

Platelet functional changes secondary to hepatocholestasis and elevation of serum bile acids

Thrombosis Research, 1988
Thrombosis Research 52 (1988) 649-654. doi:10.1016/0049-3848(88)90137-5 ; Received by publisher: 1986-10-17 ; Harvest Date: 2016-01-04 12:21:02 ; DOI:10.1016/0049-3848(88)90137-5 ; Page Range: 649 ...
Department of Medical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA ( host institution ), Bowen, Diana J. ( author ), Clemmons, Roger M. ( author ), Meyer, Dennis J. ( author ), Dorsey-Lee, Mary R. ( author )   +4 more
openaire   +3 more sources

Collaborative Metabolism: Gut Microbes Play a Key Role in Canine and Feline Bile Acid Metabolism

Veterinary Sciences
Bile acids, produced by the liver and secreted into the gastrointestinal tract, are dynamic molecules capable of impacting the overall health of dogs and cats in many contexts.
John C. Rowe, Jenessa A. Winston
doaj   +1 more source

Allo-lithocholic acid, a microbiome derived secondary bile acid, attenuates liver fibrosis

Biochemical Pharmacology
Secondary bile acids, lithocholic acid and deoxycholic acid (LCA and DCA), are dehydroxylated derivatives of primary bile acids. However, in addition to LCA and DCA the intestinal microbiota produced a variety of poorly characterized metabolites.
Marchianò, Silvia, Biagioli, Michele, Giorgio, Cristina Di, Massa, Carmen, Bellini, Rachele, Bordoni, Martina, Urbani, Ginevra, Lachi, Ginevra, Sepe, Valentina, Morretta, Elva, Distrutti, Eleonora, Zampella, Angela, Monti, Maria Chiara, Fiorucci, Stefano   +13 more
openaire   +4 more sources

Modulation of In Vitro Macrophage Responses via Primary and Secondary Bile Acids in Dogs. [PDF]

Animals (Basel), 2023
Manchester AC, Chow L, Wheat W, Dow S.
europepmc   +1 more source

Loss of TGR5-activating bile acids is associated with disease activity in inflammatory bowel disease

Scientific Reports
The gut microbiota communicates extensively with its host through small metabolites, such as bile acids. Primary bile acids are synthesized by the host and secreted into the intestine, where they are actively converted by the microbiota into secondary ...
Johannes Stallhofer, Julia Leonhardt, Juliane Semmler, Sophie Neugebauer, Michael Kiehntopf, Wiebke Löhden, Lea Homeister, Martin Ungelenk, Christian A. Hübner, Arndt Steube, Silvio Waschina, Andreas Stallmach   +11 more
doaj   +1 more source

Secondary bile acids function through the vitamin D receptor in myeloid progenitors to promote myelopoiesis. [PDF]

Blood Adv, 2023
Thompson B, Lu S, Revilla J, Uddin MJ, Oakland DN, Brovero S, Keles S, Bresnick EH, Petri WA, Burgess SL.   +9 more
europepmc   +1 more source

Emerging role of the crosstalk between gut microbiota and liver metabolome of subterranean herbivores in response to toxic plants

Ecotoxicology and Environmental Safety
Plant secondary metabolites (PSMs) are a defense mechanism against herbivores, which in turn use detoxification metabolism to process ingested and absorbed PSMs.
Yuchen Tan, Baohui Yao, Yukun Kang, Shangli Shi, Zunji Shi, Junhu Su   +5 more
doaj   +1 more source

Systematic identification of secondary bile acid production genes in global microbiome

mSystems
ABSTRACT Microbial metabolism of bile acids (BAs) is crucial for maintaining homeostasis in vertebrate hosts and environments. Although certain organisms involved in bile acid metabolism have been identified, a global, comprehensive elucidation of the microbes, metabolic enzymes, and bile acid
Yuwei Yang, Wenxing Gao, Ruixin Zhu, Liwen Tao, Wanning Chen, Xinyue Zhu, Mengping Shen, Tingjun Xu, Tingting Zhao, Xiaobai Zhang, Lixin Zhu, Na Jiao   +11 more
openaire   +3 more sources