Results 61 to 70 of about 60,836 (146)

Research Progress in Bile Acid Receptor-Mediated Improvement of Intestinal Health by Natural Products [PDF]

Shipin Kexue
Bile acids play an important role in intestinal health, and an imbalance in bile acid homeostasis is closely related to intestinal diseases such as inflammatory bowel disease, irritable bowel syndrome, bile acid diarrhea, and colorectal cancer.
LIU Qi, CHEN Siyang, HAN Xiaoqian, LI Shuting, HAN Feifei
doaj   +1 more source

Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection

BMC Gastroenterology, 2018
Background Alteration of the gut microbiota by repeated antibiotic treatment increases susceptibility to Clostridioides difficile infection. Faecal microbiota transplantation from donors with a normal microbiota effectively treats C. difficile infection.
Jillian R.-M. Brown, Burkhardt Flemer, Susan A. Joyce, Akbar Zulquernain, Donal Sheehan, Fergus Shanahan, Paul W. O’Toole   +6 more
doaj   +1 more source

Secondary bile acids effects in colon pathology. Experimental mice study [PDF]

Acta Cirurgica Brasileira, 2015
To assess whether deoxycholic acid (DOC) and lithocholic acid (LCA) administered in a period of six months in a concentration of 0.25% may have a carcinogenic role in mice colon.The study used C57BL6 female mice divided into four groups. The control group received a balanced diet and the others received diets supplemented with 0.25% DOC, 0.25% LCA and ...
Saracut, Claudiu, Molnar, Calin, Russu, Cristian, Todoran, Nicoleta, Vlase, Laurian, Turdean, Sabin, Voidazan, Septimiu, Copotoiu, Constantin   +7 more
openaire   +5 more sources

Bile acids and their receptors in hepatic immunity

Liver Research
Similarly to conventional steroids, bile acids function as signaling molecules, acting on a family of membrane and nuclear receptors. The best-characterized bile acid-regulated receptors are the farnesoid X receptor, activated by primary bile acids, and ...
Stefano Fiorucci, Silvia Marchianò, Eleonora Distrutti, Michele Biagioli   +3 more
doaj   +1 more source

Altered fecal bile acid composition in active ulcerative colitis

Lipids in Health and Disease, 2023
Background Disturbed bile acid homeostasis associated with a rise of primary and a decline of secondary bile acids is a consistent finding in inflammatory bowel diseases (IBDs).
Stefanie Sommersberger, Stefan Gunawan, Tanja Elger, Tanja Fererberger, Johanna Loibl, Muriel Huss, Arne Kandulski, Sabrina Krautbauer, Martina Müller, Gerhard Liebisch, Christa Buechler, Hauke Christian Tews   +11 more
doaj   +1 more source

Intestinal Absorption of Bile Salts

Canadian Journal of Gastroenterology, 1990
Bile acids are secreted from the liver into the duodenum where they aid in the digestion and absorption of dietary lipids. Absorption of bile acids occurs through both ionic and nonionic diffusion in the jejunum and colon and through an active sodium ion-
Karen Madsen
doaj   +1 more source

Diversification of host bile acids by members of the gut microbiota

Gut Microbes, 2020
Bile acid biotransformation is a collaborative effort by the host and the gut microbiome. Host hepatocytes synthesize primary bile acids from cholesterol.
Jenessa A. Winston, Casey M. Theriot
doaj   +1 more source

The ‘in vivo lifestyle’ of bile acid 7α-dehydroxylating bacteria: comparative genomics, metatranscriptomic, and bile acid metabolomics analysis of a defined microbial community in gnotobiotic mice

Gut Microbes, 2020
The formation of secondary bile acids by gut microbes is a current topic of considerable biomedical interest. However, a detailed understanding of the biology of anaerobic bacteria in the genus Clostridium that are capable of generating secondary bile ...
Jason M. Ridlon, Saravanan Devendran, João Mp Alves, Heidi Doden, Patricia G. Wolf, Gabriel V. Pereira, Lindsey Ly, Alyssa Volland, Hajime Takei, Hiroshi Nittono, Tsuyoshi Murai, Takao Kurosawa, George E. Chlipala, Stefan J. Green, Alvaro G. Hernandez, Christopher J. Fields, Christy L. Wright, Genta Kakiyama, Isaac Cann, Purna Kashyap, Vance McCracken, H. Rex Gaskins   +21 more
doaj   +1 more source

Acute gastrointestinal graft-versus-host disease is associated with reductions of secondary bile acids following allogeneic hematopoietic cell transplantation

Frontiers in Microbiology
IntroductionAllogeneic hematopoietic cell transplantation (HCT) can cure hematologic malignancies, but 30-70% of recipients experience acute graft-versus-host disease (GvHD). GvHD is associated with perturbations in the gut microbiome.
Robin Cagle, Robin Cagle, Sean Proll, Samuel S. Minot, Hayley Purcell, Wentao Zhu, Danijel Djukovic, Congzhou Liu, Tina Fiedler, Martha DeMeules, Marco Mielcarek, Marco Mielcarek, Sujatha Srinivasan, Daniel Raftery, Daniel Raftery, Michael Wu, Michael Wu, Steven A. Pergam, Steven A. Pergam, David N. Fredricks, David N. Fredricks, David N. Fredricks   +21 more
doaj   +1 more source

Metagenomic, metabolomic, and lipidomic shifts associated with fecal microbiota transplantation for recurrent Clostridioides difficile infection

mSphere
Recurrent C. difficile infection (rCDI) is an urgent public health threat, for which the last resort and lifesaving treatment is a fecal microbiota transplant (FMT).
Arthur S. McMillan, Guozhi Zhang, Michael K. Dougherty, Sarah K. McGill, Ajay S. Gulati, Erin S. Baker, Casey M. Theriot   +6 more
doaj   +1 more source