Results 41 to 50 of about 60,836 (146)

Increased Secondary/Primary Bile Acid Ratio in Chronic Heart Failure [PDF]

Journal of Cardiac Failure, 2017
Bile acids (BAs) are now recognized as signaling molecules and emerging evidence suggests that BAs affect cardiovascular function. The gut microbiota has recently been linked to the severity of heart failure (HF), and microbial metabolism has a major impact on BA homeostasis.
Cristiane C.K. Mayerhofer, Thor Ueland, Kaspar Broch, Royce P. Vincent, Gemma F. Cross, Christen P. Dahl, Pål Aukrust, Lars Gullestad, Johannes R. Hov, Marius Trøseid   +9 more
openaire   +5 more sources

A gut microbiota-independent mechanism shapes the bile acid pool in mice with MASH

JHEP Reports
Background & Aims: An imbalance between primary and secondary bile acids contributes to the development of metabolic dysfunction-associated steatohepatitis (MASH).
Justine Gillard, Martin Roumain, Corinne Picalausa, Morgane M. Thibaut, Laure-Alix Clerbaux, Anne Tailleux, Bart Staels, Giulio G. Muccioli, Laure B. Bindels, Isabelle A. Leclercq   +9 more
doaj   +1 more source

Effects of cholecystectomy on the kinetics of primary and secondary bile acids. [PDF]

Journal of Clinical Investigation, 1989
Removal of the gallbladder is thought to increase formation and pool size of secondary bile acids, mainly deoxycholic acid (DCA), by increased exposure of primary bile acids (cholic acid [CA], chenodeoxycholic acid [CDCA]) to bacterial dehydroxylation in the intestine.
F, Berr, F, Stellaard, E, Pratschke, G, Paumgartner   +3 more
openaire   +2 more sources

Secondary Bile Acid Derivatives Are Contributors to the Fecal Bile Acid Pool and Associated With Bile Acid–Modulating Nutrients

The Journal of Nutrition
Accumulation of hydrophobic bile acids (BAs) is linked with cancer development. However, derivatives of deoxycholic acid (DCA) and lithocholic acid (LCA) produced via bacterial metabolism may mitigate the proinflammatory and cytotoxic effects of hydrophobic BAs. The impact of diet on secondary BA derivative production has not been determined.This study
Patricia G Wolf, Caitlin Welsh, Briawna Binion, Hanchu Dai, Manoela Lima Oliveira, Alyshia Hamm, Sarah Goldberg, Pius Sarfo Buobu, Teresa Schering, Sevasti Vergis, Nicollette Kessee, Sandra L Gomez, Cemal Yazici, Mark Maienschein-Cline, Doratha A Byrd, H Rex Gaskins, Jason M. Ridlon, Ece Mutlu, Chris Greening, Lisa Tussing-Humphreys   +19 more
openaire   +3 more sources

Review: microbial transformations of human bile acids

Microbiome, 2021
Bile acids play key roles in gut metabolism, cell signaling, and microbiome composition. While the liver is responsible for the production of primary bile acids, microbes in the gut modify these compounds into myriad forms that greatly increase their ...
Douglas V. Guzior, Robert A. Quinn
doaj   +1 more source

Secondary bile acids as immune and metabolic mediators

Trends in Immunology
Bile acids are cholesterol derivatives, generated by the coordinated intervention of human and bacterial genes, functioning as endogenous ligands for multiple transcription factors and receptors throughout the body. While only two primary bile acids are generated by the human liver, the intestinal microbiota is the source of hundreds of secondary bile ...
Fiorucci, Stefano, Biagioli, Michele, Marchianò, Silvia, Zampella, Angela, Distrutti, Eleonora   +4 more
openaire   +2 more sources

Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium

Journal of Lipid Research, 2012
The human bile acid pool composition is composed of both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid).
Jason M. Ridlon, Phillip B. Hylemon
doaj   +1 more source

Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids. [PDF]

Cell Chem Biol, 2019
Clostridium scindens biotransforms primary bile acids into secondary bile acids, and is correlated with inhibition of Clostridium difficile growth in vivo. The aim of the current study was to determine how C. scindens regulates C. difficile growth in vitro and if these interactions might relate to the regulation of gut microbiome structure in vivo. The
Kang JD, Myers CJ, Harris SC, Kakiyama G, Lee IK, Yun BS, Matsuzaki K, Furukawa M, Min HK, Bajaj JS, Zhou H, Hylemon PB.   +11 more
europepmc   +4 more sources

Structure and functional characterization of a bile acid 7α dehydratase BaiE in secondary bile acid synthesis [PDF]

Proteins: Structure, Function, and Bioinformatics, 2016
ABSTRACTConversion of the primary bile acids cholic acid (CA) and chenodeoxycholic acid (CDCA) to the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA) is performed by a few species of intestinal bacteria in the genus Clostridium through a multistep biochemical pathway that removes a 7α‐hydroxyl group.
Bhowmik, Shiva, Chiu, Hsien-Po, Jones, David H., Chiu, Hsiu-Ju, Miller, Mitchell D., Xu, Qingping, Farr, Carol L., Ridlon, Jason M., Wells, James E., Elsliger, U.S. Meat Animal Research Center-Andre, Wilson, Ian A., Hylemon, Phillip B., Lesley, Scott A.   +12 more
openaire   +2 more sources

Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets [PDF]

Diabetes & Metabolism Journal, 2019
Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in
Jessica M. Ferrell, John Y. L. Chiang
doaj   +1 more source