Results 21 to 30 of about 60,836 (146)
Secondary bile acids: an underrecognized cause of colon cancer [PDF]
World Journal of Surgical Oncology, 2014 Abstract Bile acids were first proposed as carcinogens in 1939. Since then, accumulated evidence has linked exposure of cells of the gastrointestinal tract to repeated high physiologic levels of bile acids as an important risk factor for gastrointestinal cancers.
Ajouz, Hana +2 more
openaire +2 more sources
Bile acid-independent protection against Clostridioides difficile infection.
PLoS Pathogens, 2021 Clostridioides difficile infections occur upon ecological / metabolic disruptions to the normal colonic microbiota, commonly due to broad-spectrum antibiotic use.
Andrea Martinez Aguirre +8 more
doaj +1 more source
Profiling of Urinary Glucuronidated Bile Acids across Age Groups
Metabolites, 2022 We investigated the age-dependent changes in urinary excretion of glucuronidated bile acids at the C-3 position. Bile acid 3-glucuronides accounted for 0.5% of urinary bile acids in neonates, and the proportion of bile acid 3-glucuronides plateaued at 1 ...
Yamato Muto +6 more
doaj +1 more source
Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer [PDF]
International Journal of Molecular Sciences, 2019 Huawei Zeng +2 more
exaly +2 more sources
Abnormal metabolism of secondary bile acids in patients with cirrhosis [PDF]
Gut, 1970 The composition of bile acids in human bile was determined in bile-rich duodenal fluid on four consecutive days in a group of seven patients with cirrhosis and eight control patients with no liver disease. There was a marked reduction of secondary biliary bile acids in cirrhotic patients. Possible mechanisms for these changes are discussed.
Z R, Vlahcevic +3 more
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mSphere, 2016 It is hypothesized that the depletion of microbial members responsible for converting primary bile acids into secondary bile acids reduces resistance to Clostridium difficile colonization. To date, inhibition of C.
Casey M. Theriot +2 more
doaj +1 more source
Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice [PDF]
PLOS ONE, 2019 Ursodeoxycholic acid (commercially available as ursodiol) is a naturally occurring bile acid that is used to treat a variety of hepatic and gastrointestinal diseases. Ursodiol can modulate bile acid pools, which have the potential to alter the gut microbiota community structure.
Jenessa A. Winston +4 more
openaire +4 more sources
Biosynthesis and biotransformation of bile acids [PDF]
Hospital Pharmacology, 2017 Bile acids are steroidal compounds, which contain 24 carbon atoms. They can be classified into two major groups: primary and secondary. The most abundant bile acids: The primary bile acids include cholic acid and chenodeoxycholic acid, while the major ...
Šarenac Tanja M., Mikov Momir M.
doaj +1 more source
Impaired Bile Acid Homeostasis in Children with Severe Acute Malnutrition. [PDF]
PLoS ONE, 2016 OBJECTIVE:Severe acute malnutrition (SAM) is a major cause of mortality in children under 5 years and is associated with hepatic steatosis. Bile acids are synthesized in the liver and participate in dietary fat digestion, regulation of energy expenditure,
Ling Zhang +10 more
doaj +1 more source
Archives of Medical Science, 2021 Introduction Infant jaundice is a common condition which results from a high concentration of serum bilirubin. Phototherapy is a widely used treatment for bilirubin clearance.
Kun Zhang +5 more
doaj +1 more source