Results 11 to 20 of about 60,836 (146)
Secondary bile acids and the biliary epithelia: The good and the bad. [PDF]
World J Gastroenterol, 2023 The biliary tract has been considered for several decades a passive system just leading the hepatic bile to the intestine. Nowadays several researches demonstrated an important role of biliary epithelia (i.e. cholangiocytes) in bile formation. The study of biliary processes therefore maintains a continuous interest since the possible important ...
Lenci I +4 more
europepmc +4 more sources
Impact of Primary and Secondary Bile Acids on Clostridioides difficile Infection. [PDF]
Pol J Microbiol, 2022 Abstract Primary bile acids (BAs), synthesized from cholesterol in the liver, after their secretion with bile into the intestinal lumen, are transformed by gut microbiota to secondary BAs. As natural detergents, BAs play a key role in the digestion and absorption of lipids and liposoluble vitamins.
Łukawska A, Mulak A.
europepmc +5 more sources
iScience, 2021 Summary: Bile acids are metabolites of cholesterol that facilitate lipid digestion and absorption in the small bowel. Bile acids work as agonists of receptors to regulate their own metabolism.
Tomoki Ota +9 more
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Bile acids as inflammatory mediators and modulators of intestinal permeability
Frontiers in Immunology, 2022 Bile acids are critical for the digestion and absorption of lipids and fat-soluble vitamins; however, evidence continues to emerge supporting additional roles for bile acids as signaling molecules. After they are synthesized from cholesterol in the liver,
Nathan Calzadilla +9 more
doaj +1 more source
Carcinogenicity of deoxycholate, a secondary bile acid [PDF]
Archives of Toxicology, 2011 High dietary fat causes increased bile acid secretion into the gastrointestinal tract and is associated with colon cancer. Since the bile acid deoxycholic acid (DOC) is suggested to be important in colon cancer etiology, this study investigated whether DOC, at a high physiologic level, could be a colon carcinogen.
Bernstein, Carol +6 more
openaire +2 more sources
Fecal Bile Acids and Neutral Sterols Are Associated with Latent Microbial Subgroups in the Human Gut
Metabolites, 2022 Bile acids, neutral sterols, and the gut microbiome are intricately intertwined and each affects human health and metabolism. However, much is still unknown about this relationship. This analysis included 1280 participants of the KORA FF4 study.
Taylor A. Breuninger +10 more
doaj +1 more source
Research on Gut Microbiota-Derived Secondary Bile Acids in Cancer Progression. [PDF]
Integr Cancer Ther, 2022 The interaction between gut microbiota-derived metabolites and the body plays a significant role in the occurrence and development of cancer. Secondary bile acids (BAs) are the important products produced from gut microbial fermentation of primary BAs, mainly deoxycholic acid (DCA) and lithocholic acid (LCA).
Yang R, Qian L.
europepmc +4 more sources
Metabolites, 2022 Bile acids are a key mediator of the molecular microbiome-host interaction, and various mass spectrometry-based assays have been developed in the recent decade to quantify a wide range of bile acids.
Sven-Bastiaan Haange +15 more
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The Hylemon-Björkhem pathway of bile acid 7-dehydroxylation: history, biochemistry, and microbiology
Journal of Lipid Research, 2023 Bile acids are detergents derived from cholesterol that function to solubilize dietary lipids, remove cholesterol from the body, and act as nutrient signaling molecules in numerous tissues with functions in the liver and gut being the best understood ...
Jason M. Ridlon +2 more
doaj +1 more source
Cholestasis impairs gut microbiota development and bile salt hydrolase activity in preterm neonates
Gut Microbes, 2023 Cholestasis refers to impaired bile flow from the liver to the intestine. In neonates, cholestasis causes poor growth and may progress to liver failure and death.
Lauren E. Lynch +7 more
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