Results 71 to 80 of about 323,138 (302)

A gut microbiota-independent mechanism shapes the bile acid pool in mice with MASH

JHEP Reports
Background & Aims: An imbalance between primary and secondary bile acids contributes to the development of metabolic dysfunction-associated steatohepatitis (MASH).
Justine Gillard, Martin Roumain, Corinne Picalausa, Morgane M. Thibaut, Laure-Alix Clerbaux, Anne Tailleux, Bart Staels, Giulio G. Muccioli, Laure B. Bindels, Isabelle A. Leclercq   +9 more
doaj   +1 more source

Review: microbial transformations of human bile acids

Microbiome, 2021
Bile acids play key roles in gut metabolism, cell signaling, and microbiome composition. While the liver is responsible for the production of primary bile acids, microbes in the gut modify these compounds into myriad forms that greatly increase their ...
Douglas V. Guzior, Robert A. Quinn
doaj   +1 more source

Decreased secondary faecal bile acids in children with ulcerative colitis and Clostridioides difficile infection

Alimentary Pharmacology and Therapeutics, 2021
Patients with ulcerative colitis (UC) have an increased risk of Clostridioides difficile infection (CDI). There is a well‐documented relationship between bile acids and CDI.
Sarah Rotondo-Trivette, Beibei Wang, C. Gayer, Riddhi Parsana, Y. Luan, Fengzhu Sun, S. Michail   +6 more
semanticscholar   +1 more source

Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets [PDF]

Diabetes & Metabolism Journal, 2019
Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in
Jessica M. Ferrell, John Y. L. Chiang
doaj   +1 more source

Sensitivity of activated human lymphocytes to cyclosporine and its metabolites [PDF]

, 1988
Alloreactive T cells generated as clones from mixed lymphocyte cultures, or propagated from heart or liver transplant biopsies, were tested for secondary proliferation measured in the primed lymphocyte test in the presence of Cyclosporine A and ...
Burckart, G, Duquesnoy, RJ, Makowka, L, Murase, N, Starzl, TE, Van Thiel, DH, Venkataramanan, R, Wang, CP, Zeevi, A   +8 more
core   +1 more source

The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding [PDF]

, 2020
The early life gut microbiota plays a crucial role in regulating and maintaining the intestinal barrier, with disturbances in these communities linked to dysregulated renewal and replenishment of intestinal epithelial cells.
Alastair J. M. Watson, Cristina Alcon‐Giner, d'Hennezel E, Federico Bernuzzi, Gwénaëlle Le Gall, Hedblom GA, Kevin R. Hughes, Lindsay J. Hall, Lisa Chalklen, Matthew J. Dalby, Potten CS, Selma‐Royo M, Shabhonam Caim, Weiser MM, Zoe Schofield   +14 more
core   +1 more source

A secondary bile acid from microbiota metabolism attenuates ileitis and bile acid reduction in subclinical necrotic enteritis in chickens [PDF]

Journal of Animal Science and Biotechnology, 2020
Abstract Background Clostridium perfringens-induced chicken necrotic enteritis (NE) is responsible for substantial economic losses worldwide annually. Recently, as a result of antibiotic growth promoter prohibition, the prevalence of NE in chickens has reemerged.
Mohit Bansal, Ying Fu, Bilal Alrubaye, Mussie Abraha, Ayidh Almansour, Anamika Gupta, Rohana Liyanage, Hong Wang, Billy Hargis, Xiaolun Sun   +9 more
openaire   +3 more sources

Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells [PDF]

, 2009
In patients with bile acid malabsorption, high concentrations of bile acids enter the colon and stimulate Cl− and fluid secretion, thereby causing diarrhoea. However, deoxycholic acid (DCA), the predominant colonic bile acid, is normally present at lower
Alan F. Hofmann, Barcelo, Barrett, Bertelsen, Cartwright, Chadwick, Cheng, Cheng, Christine Marsh, Dawson, Dawson, Devor, Dharmsathaphorn, Fernandez-Banares, Gail Ferguson, Gelbmann, Gordon, Hamilton, Hofmann, J-P, Kalia, Keely, Keely, Keely, Khurana, Kok, Kruis, Magdalena S. Mroz, Mauricio, Mekjian, Merchant, Michael M. Scharl, Milovic, Montrose, Muhlbauer, Münch, Niamh Keating, Nyhlin, Potter, Raimondi, Smith, Stephen J. Keely, Teem, Ung, Venkatasubramanian, Weihrauch   +45 more
core   +1 more source

Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium

Journal of Lipid Research, 2012
The human bile acid pool composition is composed of both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid).
Jason M. Ridlon, Phillip B. Hylemon
doaj   +1 more source

Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases

Cells, 2023
The intestinal barrier is a precisely regulated semi-permeable physiological structure that absorbs nutrients and protects the internal environment from infiltration of pathological molecules and microorganisms. Bile acids are small molecules synthesized
Linsen Shi, Lihua Jin, Wendong Huang
doaj   +1 more source