Viral subversion of B cell responses within secondary lymphoid organs [PDF]
Nature Reviews Immunology, 2017 Antibodies play a crucial role in virus control. The production of antibodies requires virus-specific B cells to encounter viral antigens in lymph nodes, become activated, interact with different immune cells, proliferate and enter specific differentiation programmes.
Kuka, Mirela, Iannacone, Matteo
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True infliximab resistance in rheumatoid arthritis: a role for lymphotoxin α? [PDF]
, 2004 Background: The combination of methotrexate and the anti-tumour necrosis factor (TNF) antibody infliximab is a very effective treatment for rheumatoid arthritis (RA). However, a proportion of patients are not responsive to this treatment. Inefficacy may
Bingham, S.J. +5 more
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Organoid Models of Lymphoid Tissues
OrganoidsLymphoid organs are critical for organizing the development of the immune system, generating immune tolerance, and orchestrating the adaptive immune response to foreign antigens.
Ania Bogoslowski +3 more
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Optimization of Organotypic Cultures of Mouse Spleen for Staining and Functional Assays
Frontiers in Immunology, 2020 By preserving cell viability and three-dimensional localization, organotypic culture stands out among the newest frontiers of cell culture. It has been successfully employed for the study of diseases among which neoplasias, where tumoral cells take ...
Francesca Finetti +9 more
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Oral, nasal and pharyngeal exposure to lipopolysaccharide causes a fetal inflammatory response in sheep. [PDF]
, 2015 BackgroundA fetal inflammatory response (FIR) in sheep can be induced by intraamniotic or selective exposure of the fetal lung or gut to lipopolysaccharide (LPS).
Jobe, Alan H +7 more
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Clusterin is a potential lymphotoxin beta receptor target that is upregulated and accumulates in germinal centers of mouse spleen during immune response. [PDF]
PLoS ONE, 2014 Clusterin is a multifunctional protein that participates in tissue remodeling, apoptosis, lipid transport, complement-mediated cell lysis and serves as an extracellular chaperone. The role of clusterin in cancer and neurodegeneration has been extensively
Marina A Afanasyeva +5 more
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BAFF induces CXCR5 expression during B cell differentiation in bone marrow
Biochemistry and Biophysics Reports, 2023 B cell activating factor (BAFF) plays an important role in antibody production through differentiation and maturation of B cells mainly in secondary lymphoid organs.
Hajime Koizumi +3 more
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Regulation of adaptive immune responses by guiding cell movements in the spleen
Frontiers in Microbiology, 2015 The spleen combines the innate and adaptive immune systems in a uniquely organized way. The excision of spleen will induce many complications, especially the increased susceptibility to infections.
lintao ezhao +3 more
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Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80(dim), CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients [PDF]
, 1996 We have shown previously that granulocyte-macrophage colony-stimulating factor-stimulated mouse bone marrow-derived MHC class II+ dendritic cell (DC) progenitors that are deficient in cell surface expression of the costimulatory molecules B7-1 (CD8O) and
Angus W. Thomson +48 more
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