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Metabolomics for Secondary Metabolite Research [PDF]

Metabolites, 2013
Metabolomics, the global characterization of metabolite profiles, is becoming an increasingly powerful tool for research on secondary metabolite discovery and production.
Eriko Takano, Andris Jankevics, Rainer Breitling, Ana Ceniceros   +3 more
doaj   +4 more sources

Editorial: Plant secondary metabolite biosynthesis [PDF]

Frontiers in Plant Science
Xiang Pu, Naoki Kitaoka, Carlos E. Rodríguez-López, Carlos E. Rodríguez-López, Shilin Chen   +4 more
doaj   +2 more sources

Transcriptome and translatome profiles of Streptomyces species in different growth phases. [PDF]

, 2020
Streptomyces are efficient producers of various bioactive compounds, which are mostly synthesized by their secondary metabolite biosynthetic gene clusters (smBGCs).
Cho, Byung-Kwan, Cho, Suhyung, Hwang, Soonkyu, Kim, Woori, Lee, Namil, Lee, Yongjae, Palsson, Bernhard   +6 more
core   +1 more source

The Effects of Domestication on Secondary Metabolite Composition in Legumes

Frontiers in Genetics, 2020
Legumes are rich in secondary metabolites, such as polyphenols, alkaloids, and saponins, which are important defense compounds to protect the plant against herbivores and pathogens, and act as signaling molecules between the plant and its biotic ...
Yee-Shan Ku, Carolina A. Contador, Ming-Sin Ng, Jeongjun Yu, Gyuhwa Chung, Hon-Ming Lam   +5 more
doaj   +1 more source

Metabolomics - what nomenclature to use?

Ecocycles, 2017
This Opinion paper was written to initiate a discussion on the nomenclature used in metabolomic studies. The paper is based on the belief that the currently used classification of metabolites as "primary" and "secondary" are inaccurate and somewhat ...
Tamas Komives
doaj   +1 more source

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]

, 2010
Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Alam, Mohammad T., Breitling, Rainer, HASH(0x55aa09327868), Hodgson, D. A., Merlo, Maria E., Takano, Eriko, Wellington, E. M. H.   +6 more
core   +14 more sources

The secondary metabolite bioinformatics portal: Computational tools to facilitate synthetic biology of secondary metabolite production

Synthetic and Systems Biotechnology, 2016
Natural products are among the most important sources of lead molecules for drug discovery. With the development of affordable whole-genome sequencing technologies and other ‘omics tools, the field of natural products research is currently undergoing a ...
Tilmann Weber, Hyun Uk Kim
doaj   +1 more source

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]

, 2012
Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
A Freitag, A Gevorgyan, A Mithani, Albert Gevorgyan, AM Feist, AM Feist, AM Feist, Andrzej M. Kierzek, AP Burgard, BA Pfeifer, CS Henry, D Nagrath, DC Alexander, DC Stevens, EM Paradise, Eriko Takano, FC Lee, H Ikeda, I Thiele, J Gonzalez-Lergier, J Romero, J Schellenberger, JD Orth, JL Adrio, JP Brooks, JS Edwards, K Nieselt, K Yanai, LM Blank, M DeJongh, M Durot, M Kanehisa, M Latendresse, MA Fischbach, MA Oberhardt, MA Oberhardt, MA Oberhardt, Marnix H. Medema, MH Medema, MH Medema, MH Medema, MH Medema, MT Alam, MT Alam, MW Covert, N Scherr, ND Price, ND Price, NE Lewis, Piotr Zakrzewski, PR Ives, R Breitling, R Schuetz, Rainer Breitling, SA Becker, SD Bentley, Stephen S. Fong, TD Vo, TY Kim, XQ Zhao   +59 more
core   +6 more sources

Screening of secondary metabolite biosynthesis genes of marine actinomycetes isolated from Trabzon (Black Sea) sea sediments

Turkish Journal of Agriculture: Food Science and Technology, 2017
In this study, active secondary metabolite production capacity of actinomycete isolates obtained from Trabzon (Black Sea) sea sediments was investigated by molecular techniques.
Kadriye Özcan
doaj   +1 more source

Does Osmotic Stress Affect Natural Product Expression in Fungi? [PDF]

, 2017
Acknowledgments: Russell Kerr acknowledges the assistance of Nadia Prigoda-Lee, Marius Grote, Kate McQuillan and Stephanie Duffy, and generous financial support from NSERC, the Canada Research Chair program, the Jeanne and Jean-Louis Lévesque Foundation ...
Bills, Gerald, Capon, Rob, Chi, Wei Chiung, Correa, Hebelin, Ebel, Rainer, Kerr, Russell, Overy, David, Pang, Ka Lai, Rateb, Mostafa, Roullier, Catherine, Shang, Zhuo   +10 more
core   +3 more sources