Results 91 to 100 of about 7,825,369 (248)

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Contactin-1 and contactin-2 in cerebrospinal fluid as potential biomarkers for axonal domain dysfunction in multiple sclerosis

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2018
Background Contactin-1 and contactin-2 are important for the maintenance of axonal integrity. Objective To investigate the cerebrospinal fluid levels of contactin-1 and contactin-2 in multiple sclerosis patients and controls, and their potential use as ...
Madhurima Chatterjee, Marleen JA Koel-Simmelink, Inge MW Verberk, Joep Killestein, Hugo Vrenken, Christian Enzinger, Stefan Ropele, Franz Fazekas, Michael Khalil, Charlotte E Teunissen   +9 more
doaj   +1 more source

Understanding progression in primary progressive multiple sclerosis: a longitudinal clinical and magnetic resonance imaging study [PDF]

, 2010
The work in this thesis applies magnetization transfer imaging (MTI) and conventional MRI measures (brain volume, T2 lesion load and enhancing lesions) to investigate the mechanisms underlying progression in primary progressive multiple sclerosis ...
Khaleeli, Z.
core  

Engagement Patterns With an Artificial Intelligence Health Coach for Systemic Sclerosis Self‐Management: A Mixed Methods Study

Arthritis Care &Research, EarlyView.
Objective To evaluate utility of an artificial intelligence (AI) health coach for systemic sclerosis (SSc) self‐management and identify patterns associated with participant engagement. Methods We conducted a mixed methods study in which an AI health coach, powered by a large language model (LLM), was used to support self‐management for SSc.
Nirali Shah, Melanie Morris, Cristina Daraban, Sophia Johnson, Susan L. Murphy   +4 more
wiley   +1 more source

Elastomeric 3D‐Printed Microenvironments Enable Nanonewton Force Measurements in Healthy and Diseased Human Pluripotent Stem Cell‐Derived Neuroepithelial Cells

Advanced Materials, EarlyView.
We present elastomeric three‐dimensional (3D) microstructures fabricated via two‐photon polymerization (2PP) and post‐processed through wet etching, for quantifying nanonewton (nN)‐scale forces applied by healthy and diseased neural cells. The mechanically characterized free‐standing beam architectures enable measurement of traction forces of ...
Pieter F. J. van Altena, Lucia Castillo Ransanz, Ruben H. Guis, Giulia Bergamaschi, Nanne J. Paauw, Urs Staufer, Vivi M. Heine, Angelo Accardo   +7 more
wiley   +1 more source

Evidence for grey matter MTR abnormality in minimally disabled patients with early relapsing-remitting multiple sclerosis [PDF]

, 2004
Objectives: To establish whether magnetisation transfer ratio (MTR) histograms are sensitive to change in normal appearing grey matter (NAGM) in early relapsing-remitting multiple sclerosis (RRMS) in the absence of significant disability; and to assess ...
Griffin, C M B, Kapoor, R., Miller, D.H., Chard, D T, Hadjiprocopis, A., Ramio-Torrenta, L, Barker, G J; id_orcid, Davies, G.R., Ramió-Torrentà, L., Griffin, C.M.B., Rashid, W., Chard, D.T., Davies, G R, Miller, D H, Rashid, W, Thompson, A.J., Kapoor, R, Thompson, A J, Barker, G.J., Hadjiprocopis, A   +19 more
core   +1 more source

Bottom‐Up Engineering of a Human Neuromuscular System for Modeling Activity‐Induced Remodeling, Metabolic Stress, and Endothelial‐Modulated Excitability

Advanced Materials, EarlyView.
Using a bottom‐up approach, we engineered a human neuromuscular microchip to investigate distinct adaptive responses to neural stimulation and metabolic stress. Further integration of endothelial cells revealed their critical role in modulating neuromuscular excitability, establishing a comprehensive neurovascular‐muscular model.
Jinchul Ahn, Min‐seop Kim, Ju‐Hee Kim, Seok‐Hyeon Kang, Dain Lee, Hui‐Wen Liu, Seung‐cheol Shin, Kyuhwan Na, Yesl Jun, Oak‐Kee Hong, Ji Hun Yang, Jin‐A Kim, Hwanseok Jang, Hong Nam Kim, Roger D. Kamm, Ji‐Hoon Kim, Jang‐Won Son, Seok Chung   +17 more
wiley   +1 more source

Coping strategies and mood profiles in patients with multiple sclerosis

Arquivos de Neuro-Psiquiatria, 2014
Objective: The aim of the present study was to investigate the coping strategies, mood characteristics and the association between these aspects in patients diagnosed with multiple sclerosis and healthy subjects.
Aysel Milanlioglu, Pinar Güzel Özdemir, Vedat Cilingir, Tezay Çakin Gülec, Mehmet Nuri Aydin, Temel Tombul   +5 more
doaj   +1 more source

Migration and infectious disease in the etiology of multiple sclerosis: A case-control study

, 1989
Epidemiological study on multiple sclerosis risk of migration from South to North ...
Altobelli A., Italian Multiple Sclerosis Study Group, GRANIERI, Enrico Gavino Giuseppe   +2 more
core  

Fluoxetine as disease modifying treatment in multiple sclerosis : rationale, evaluation of the use of MRI to monitor treatment, and preliminary findings [PDF]

, 2009
Patients with multiple sclerosis (MS) lack astrocytic β2-adrenergic receptors and this may contribute to the focal inflammatory demyelinating lesions and axonal degeneration that characterize this disease.
Mostert, Jop Pieter,, Mostert, Jop Pieter   +1 more
core   +16 more sources