Results 101 to 110 of about 7,825,369 (248)

Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis.

, 2013
Background: It is unclear if all patients with relapsing remitting multiple sclerosis (RRMS) ultimately develop progressive MS. Onset of progressive disease course seems to be age- rather than disease duration-dependent. Some forms of progressive MS (e.g.
Weinshenker, Brian G., Tang, Junger, Atkinson, Elizabeth J., Kale, Nilufer, Lucchinetti, Claudia F., Kantarci, Orhun H., Siva, Aksel, Abou Zeid, Nuhad, Keegan, B. Mark, Crusan, Daniel J., Tutuncu, Melih, Pirko, Istvan, Noseworthy, John H., Rodriguez, Moses, Pittock, Sean J.   +14 more
core   +1 more source

The Bayesian risk estimate at onset (BREMSO) correlates with cognitive and physical disability in patients with early multiple sclerosis [PDF]

, 2018
Background: Prevention of long-term disability is the goal of therapeutic intervention in Relapsing Remitting MS (RRMS). The Bayesian Risk Estimate for MS at Onset (BREMSO) gives an individual risk score predicting disease evolution into Secondary ...
Jalkh, Youmna, Hannoun, S., Haddad, Ribal, Saba, Leslie, Khoury, Samia J., El-Ayoubi, Nabil K., Yamout, Bassem I., Said, Marianne   +7 more
core   +1 more source

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Siponimod in secondary progressive multiple sclerosis

International Archives of Health Sciences, 2020
Jamir Pitton Rissardo, Ana Leticia Fornari Caprara   +1 more
doaj   +1 more source

Assessment and optimisation of MRI measures of atrophy as potential markers of disease progression in multiple sclerosis [PDF]

, 2008
There is a need for sensitive measures of disease progression in multiple sclerosis (MS) to monitor treatment effects and understand disease evolution. MRI measures of brain atrophy have been proposed for this purpose. This thesis investigates a number
Anderson, V.
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Progressive multiple sclerosis: Evaluating current therapies and exploring future treatment strategies

Neurotherapeutics
Progressive forms of multiple sclerosis (MS) include primary progressive MS (PPMS) and secondary progressive MS (SPMS). Unlike relapsing-remitting MS (RRMS), progressive MS is recognized by relentless progression with accumulating disability, rare to no ...
Marelisa Albelo-Martínez, Syed Rizvi
doaj   +1 more source

Effect of disease duration on personality type in multiple sclerosis patients and healthy individual

Advanced Biomedical Research, 2016
Background: Multiple sclerosis may have profound emotional consequences. The relation between psychological and physical factors could lead patients toward unforeseen disease.
Sahar Vesal, Leila Dehghani, Masoud Etemadifar, Elahe Poorazizi, Sima Akhavan, Samaneh Mazrouei, Nasim Mehdizadeh, Zahra Saraf   +7 more
doaj   +1 more source