Results 61 to 70 of about 11,591,695 (294)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Protein secondary structure prediction (PSSP) using different machine algorithms
Egyptian Journal of Medical Human Genetics, 2021 Background The computational biology approach has advanced exponentially in protein secondary structure prediction (PSSP), which is vital for the pharmaceutical industry.
Heba M. Afify +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
PROTINFO: secondary and tertiary protein structure prediction [PDF]
Nucleic Acids Research, 2003 Information about the secondary and tertiary structure of a protein sequence can greatly assist biologists in the generation and testing of hypotheses, as well as design of experiments. The PROTINFO server enables users to submit a protein sequence and request a prediction of the three-dimensional (tertiary) structure based on comparative modeling ...
Ling-Hong Hung, Ram Samudrala
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Protein secondary structure: entropy, correlations and prediction [PDF]
Bioinformatics, 2004 Abstract Motivation: Is protein secondary structure primarily determined by local interactions between residues closely spaced along the amino acid backbone or by non-local tertiary interactions? To answer this question, we measure the entropy densities of primary and secondary structure sequences, and the local inter-sequence mutual ...
Crooks, Gavin E., Brenner, Steven E.
openaire +3 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Protein secondary structure prediction with classifier fusion [PDF]
, 2008 The number of known protein sequences is increasing very rapidly. However, experimentally determining protein structure is costly and slow, so the number of proteins with known sequence but unknown structure is increasing. Thus, computational methods for
Pakatcı, Kemal İsa
core +1 more source
Integration of Multi-Feature Fusion and PLS-DA in Protein Secondary Structure Prediction
MATEC Web of Conferences, 2016 Protein structure prediction has become one of the central problems in the field of modern computational biology. Protein secondary structure prediction is the basis of the spatial structure prediction of proteins.
Huang Guangzao +5 more
doaj +1 more source
Prediction of backbone dihedral angles and protein secondary structure using support vector machines
BMC Bioinformatics, 2009 Background The prediction of the secondary structure of a protein is a critical step in the prediction of its tertiary structure and, potentially, its function.
Hirst Jonathan D, Kountouris Petros
doaj +1 more source