Results 71 to 80 of about 11,591,695 (294)

MPGAfold in Dengue Secondary Structure Prediction [PDF]

open access: yes, 2014
This chapter presents the computational prediction of the secondary structures within the 5' and 3' untranslated regions of the dengue virus serotype 2 (DENV2), with the focus on the conformational prediction of the two dumbbell-like structures, 5' DB and 3' DB, found in the core region of the 3' untranslated region of DENV2.
Wojciech K, Kasprzak, Bruce A, Shapiro
openaire   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Accurate prediction of protein secondary structure and solvent accessibility by consensus combiners of sequence and structure information

open access: yesBMC Bioinformatics, 2007
Background Structural properties of proteins such as secondary structure and solvent accessibility contribute to three-dimensional structure prediction, not only in the ab initio case but also when homology information to known structures is available ...
Vullo Alessandro   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Protein secondary structure prediction using neural networks and deep learning: a review

open access: yes, 2019
Literature contains over fifty years of accumulated methods proposed by researchers for predicting the secondary structures of proteins in silico. A large part of this collection is comprised of artificial neural network-based approaches, a field of ...
Khan, MGM   +5 more
core   +1 more source

CFSSP: Chou and Fasman Secondary Structure Prediction server [PDF]

open access: yes, 2013
CFSSP (Chou & Fasman Secondary Structure Prediction Server) is an online protein secondary structure prediction server. This server predicts regions of secondary structure from the protein sequence such as alpha helix, beta sheet, and turns from the ...
Ashok Kumar, T
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Evaluation of several lightweight stochastic context-free grammars for RNA secondary structure prediction

open access: yesBMC Bioinformatics, 2004
Background RNA secondary structure prediction methods based on probabilistic modeling can be developed using stochastic context-free grammars (SCFGs).
Eddy Sean R, Dowell Robin D
doaj   +1 more source

Visualization of Secondary RNA Structure Prediction Algorithms [PDF]

open access: yes, 2006
This chapter introduces the secondary structure prediction problem. It describes what the secondary structure prediction problem is and why it is important.
Hunter, Brandon
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

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