Results 91 to 100 of about 34,649 (253)

Signaling Modification by GPCR Heteromer and Its Implication on X-Linked Nephrogenic Diabetes Insipidus. [PDF]

PLoS ONE, 2016
The involvement of secretin (SCT) and secretin receptor (SCTR) in regulating body water homeostasis is well established. Identified as one of the vasopressin (Vp)-independent mechanisms in fluid balance, SCT regulates aquaporin 2 (AQP2) in the kidney ...
Hans K H Ng, Kaleeckal G Harikumar, Laurence J Miller, Billy K C Chow   +3 more
doaj   +1 more source

Detection of Exocrine Dysfunction by MRI in Patients with Early Chronic Pancreatitis [PDF]

, 2016
Purpose To determine if T1-weighted MR signal of the pancreas can be used to detect early CP. Methods A retrospective analysis was performed on 51 suspected CP patients, who had both secretin-enhanced magnetic resonance cholangiopancreatography (
Akisik, Fatih, Fogel, Evan L., Lin, Chen, Sandrasegaran, Kumaresan, Sherman, Stuart, Swensson, Jordan, Tirkes, Temel   +6 more
core   +1 more source

Incretin hormones and obesity

The Journal of Physiology, Volume 603, Issue 24, Page 7645-7659, December 15, 2025.
Abstract figure legend The incretin system in obesity. The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) (yellow) and glucagon‐like peptide‐1 (GLP‐1) (blue) are produced by the proximal and distal small intestinal epithelium, where they are released postprandially into the bloodstream to modulate a myriad of physiological and ...
Constanza Alcaino, Frank Reimann, Fiona M. Gribble   +2 more
wiley   +1 more source

MtDNA‐depleted neuronal cell transcriptomes reveal Alzheimer's disease‐related changes

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION We determined whether mitochondrial DNA (mtDNA) depletion induced Alzheimer's disease (AD)‐relevant transcription changes. METHODS Following RNA sequencing (RNA‐seq), we identified differentially expressed genes (DEGs) between SH‐SY5Y or NT2 mtDNA‐depleted (ρ0) and intact (ρ+) cell lines and quantified concordant DEG changes. Gene
Blaise W. Menta, Emily Schueddig, Amol Ranjan, Yanming Li, Shea J. Andrews, Heather M. Wilkins, Dong Pei, Russell H. Swerdlow   +7 more
wiley   +1 more source

Structure and assembly of pilotin-dependent and -independent secretins of the type II secretion system.

PLoS Pathogens, 2019
The type II secretion system (T2SS) is a cell envelope-spanning macromolecular complex that is prevalent in Gram-negative bacterial species. It serves as the predominant virulence mechanism of many bacteria including those of the emerging human pathogens
S Peter Howard, Leandro F Estrozi, Quentin Bertrand, Carlos Contreras-Martel, Timothy Strozen, Viviana Job, Alexandre Martins, Daphna Fenel, Guy Schoehn, Andréa Dessen   +9 more
doaj   +1 more source

Pancreas divisum. Correlation between anatomical abnormalities and bile precipitation in the gallbladder in seven patients [PDF]

, 2016
Pancreas divisum is a genetic defect associated with recurrent acute pancreatitis due to insufficient drainage of the accessory pancreatic duct. Seven young patients diagnosed with pancreatic divisum and thickening of the gallbladder bile as shown on ...
AL MANSOUR, Monir, Biancucci, F, Costi, Umberto, DI CELLO, Pierfrancesco, Grande, Romualdo, Izzo, Luciano, Izzo, Paolo, Izzo, Sara, Muneer, A, Pugliese, Federico, Razionale, F, Sinaimeri, G, Valabrega, Stefano   +12 more
core   +1 more source

G Protein‐Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers

MedComm, Volume 6, Issue 10, October 2025.
G protein‐coupled receptors (GPCRs) are the dynamic protein family in the human genome. GPCR dysregulation aids in the advancement of cancer through increased migration, survival, and proliferation. Novel treatments that target GPCR signaling include orthosteric ligands, biased receptor mutants, PROTACs, and antibody–drug conjugates.
Inamu Rashid Khan, Sana Khurshid, Saud Almawash, Rakesh Kumar, Ammira S. Al‐Shabeeb Akil, Ajaz A. Bhat, Muzafar A. Macha   +6 more
wiley   +1 more source

Cholangiocyte anion exchange and biliary bicarbonate excretion [PDF]

, 2006
Primary canalicular bile undergoes a process of fluidization and alkalinization along the biliary tract that is influenced by several factors including hormones, innervation/neuropeptides, and biliary constituents.
Banales, J.M. (Jesús M.), Medina, J.F. (Juan Francisco), Prieto, J. (Jesús)   +2 more
core   +1 more source

The use of octreotide in pediatric patients: Practical applications for gastrointestinal disorders and beyond: A narrative review

Nutrition in Clinical Practice, Volume 40, Issue 5, Page 1040-1052, October 2025.
Abstract Somatostatin is a naturally occurring polypeptide hormone that exerts its effect on the gastrointestinal tract by reducing exocrine and endocrine secretion, resulting in decreased motility, gastric emptying, splanchnic blood flow, fat absorption, lymphatic flow, and gallbladder contraction.
Bailey Dunn, Megan Foxe, Kathy Hunter Sprott, Jessica E. Hook, Candi Jump   +4 more
wiley   +1 more source

Architecture of the type IVa pilus machine [PDF]

, 2016
Many bacteria, including important pathogens, move by projecting grappling-hook–like extensions called type IV pili from their cell bodies. After these pili attach to other cells or objects in their environment, the bacteria retract the pili to pull ...
Chang, Yi-Wei, Iwasa, Janet, Jensen, Grant J., Rettberg, Lee A., Søgaard-Andersen, Lotte, Treuner-Lange, Anke   +5 more
core   +2 more sources