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Frontiers in Endocrinology, 2021 Metformin is an antidiabetic drug used for the treatment of diabetes and metabolic diseases. Imbalance in the autonomic nervous system (ANS) is associated with metabolic diseases.
Claudinéia Conationi da Silva Franco +22 more
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Impact of Dietary Sugars on β-Cell Function
Diabetology, 2023 Regular consumption of dietary sugars can cause significant damage to the β-cells. Almost a century after the discovery of insulin, it has been suggested that the frequent consumption of certain carbohydrates can damage pancreatic β-cells, causing ...
Ananda Malta +7 more
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The mechanism of HMGB1 secretion and release
Experimental and Molecular Medicine, 2022 High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone that maintains the structure and function of chromosomes.
Ruochan Chen, R. Kang, D. Tang
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Frontiers in Physiology, 2022 Perturbations to nutrition during critical periods are associated with changes in embryonic, fetal or postnatal developmental patterns that may render the offspring more likely to develop cardiovascular disease in later life. The aim of this study was to
Anna Rebeka Oliveira Ferreira +17 more
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The Secrets of Acinetobacter Secretion [PDF]
Trends in Microbiology, 2017 Infections caused by the bacterial pathogen Acinetobacter baumannii are a mounting concern for healthcare practitioners as widespread antibiotic resistance continues to limit therapeutic treatment options. The biological processes used by A. baumannii to cause disease are not well defined, but recent research has indicated that secreted proteins may ...
Rachel L. Kinsella +5 more
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COVID-19 During Development: A Matter of Concern
Frontiers in Cell and Developmental Biology, 2021 A new infectious disease, COVID-19, has spread around the world. The most common symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are cough and fever, but severe cases can develop acute respiratory distress syndrome. The
Lucas Paulo Jacinto Saavedra +7 more
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Molecular and Cellular Bases of Lipodystrophy Syndromes
Frontiers in Endocrinology, 2022 Lipodystrophy syndromes are rare diseases originating from a generalized or partial loss of adipose tissue. Adipose tissue dysfunction results from heterogeneous genetic or acquired causes, but leads to similar metabolic complications with insulin ...
Jamila Zammouri +20 more
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Yeast and Virus-like Particles: A Perfect or Imperfect Couple?
Applied Microbiology, 2023 Virus-like particles (VLPs) comprise viral structural proteins that self-assemble to form a particle similar to the native virus capsid. Since their discovery, they have been employed mainly as vaccines to prevent viral infection because they can elicit ...
Sara Brachelente +2 more
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Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons
eLife, 2023 Tomosyn is a large, non-canonical SNARE protein proposed to act as an inhibitor of SNARE complex formation in the exocytosis of secretory vesicles. In the brain, tomosyn inhibits the fusion of synaptic vesicles (SVs), whereas its role in the fusion of ...
Aygul Subkhangulova +6 more
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Clinical Nutrition Experimental, 2020 Summary: Leucine (Leu) is an essential branched amino acid that regulates several aspects of metabolism and may have the ability to mitigate obesity and type 2 diabetes.
Vanessa Marieli Ceglarek +8 more
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