Results 11 to 20 of about 1,140,351 (290)

Moderate Physical Training Ameliorates Cardiovascular Dysfunction Induced by High Fat Diet After Cessation of Training in Adult Rats

Frontiers in Physiology, 2019
We aimed to test whether moderate physical training can induce long-lasting protection against cardiovascular risk factors induced by high fat diet (HFD) intake, even after cessation of training.
Laize Peron Tófolo, Laize Peron Tófolo, Wilson Rinaldi, Adriane Barreto Gôngora, Camila Cristina Ianoni Matiusso, Audrei Pavanello, Ananda Malta, Douglas Lopes de Almeida, Tatiane Aparecida Ribeiro, Anna Rebeka Oliveira, Maria Natalia Chimirri Peres, James Andrew Armitage, Paulo Cezar de Freitas Mathias, Kesia Palma-Rigo, Kesia Palma-Rigo   +14 more
doaj   +1 more source

Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol

eLife, 2022
PCSK9 negatively regulates low-density lipoprotein receptor (LDLR) abundance on the cell surface, leading to decreased hepatic clearance of LDL particles and increased levels of plasma cholesterol.
Vi T Tang, Joseph McCormick, Bolin Xu, Yawei Wang, Huan Fang, Xiao Wang, David Siemieniak, Rami Khoriaty, Brian T Emmer, Xiao-Wei Chen, David Ginsburg   +10 more
doaj   +1 more source

Aerobic Exercise Training Attenuates Tumor Growth and Reduces Insulin Secretion in Walker 256 Tumor-Bearing Rats

Frontiers in Physiology, 2018
Aerobic exercise training can improve insulin sensitivity in many tissues; however, the relationship among exercise, insulin, and cancer cell growth is unclear.
Veridiana Mota Moreira, Veridiana Mota Moreira, Veridiana Mota Moreira, Claudinéia Conationi da Silva Franco, Kelly Valério Prates, Rodrigo Mello Gomes, Rodrigo Mello Gomes, Ana Maria Praxedes de Moraes, Tatiane Aparecida Ribeiro, Isabela Peixoto Martins, Carina Previate, Audrei Pavanello, Camila Cristina Ianoni Matiusso, Douglas Lopes Almeida, Flávio Andrade Francisco, Ananda Malta, Laize Peron Tófolo, Laize Peron Tófolo, Laize Peron Tófolo, Sandra da Silva Silveira, Lucas Paulo Jacinto Saavedra, Katia Machado, Paulo Henrique Olivieri da Silva, Paulo Henrique Olivieri da Silva, Gabriel S. Fabrício, Kesia Palma-Rigo, Helenir Medri de Souza, Flaviane de Fátima Silva, Giuliana Regina Biazi, Taís Susane Pereira, Elaine Vieira, Rosiane Aparecida Miranda, Júlio Cezar de Oliveira, Luiz Delmar da Costa Lima, Wilson Rinaldi, Wilson Rinaldi, Maria Ida Ravanelli, Paulo Cezar de Freitas Mathias   +37 more
doaj   +1 more source

A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise

Frontiers in Physiology, 2017
An interaction between obesity, impaired glucose metabolism and sperm function in adults has been observed but it is not known whether exposure to a diet high in fat during the peri-pubertal period can have longstanding programmed effects on reproductive
Carlos A. Ibáñez, Carlos A. Ibáñez, Rafaela P. Erthal, Fernanda M. Ogo, Maria N. C. Peres, Henrique R. Vieira, Camila Conejo, Laize P. Tófolo, Flávio A. Francisco, Sandra da Silva Silveira, Ananda Malta, Audrei Pavanello, Isabela P. Martins, Paulo H. O. da Silva, Lucas Paulo Jacinto Saavedra, Gessica D. Gonçalves, Veridiana M. Moreira, Vander S. Alves, Claudinéia C. da Silva Franco, Carina Previate, Rodrigo M. Gomes, Renan de Oliveira Venci, Francielle R. S. Dias, James A. Armitage, Elena Zambrano, Paulo C. F. Mathias, Glaura S. A. Fernandes, Kesia Palma-Rigo   +27 more
doaj   +1 more source

FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

EMBO Molecular Medicine, 2020
Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target on CAFs has not yet ...
Sonia Zaghdoudi, Emilie Decaup, Ismahane Belhabib, Rémi Samain, Stéphanie Cassant‐Sourdy, Julia Rochotte, Alexia Brunel, David Schlaepfer, Jérome Cros, Cindy Neuzillet, Manon Strehaiano, Amandine Alard, Richard Tomasini, Vinothini Rajeeve, Aurélie Perraud, Muriel Mathonnet, Oliver MT Pearce, Yvan Martineau, Stéphane Pyronnet, Corinne Bousquet, Christine Jean   +20 more
doaj   +1 more source

Maternal low intensity physical exercise prevents obesity in offspring rats exposed to early overnutrition

Scientific Reports, 2017
Low intensity exercise during pregnancy and lactation may create a protective effect against the development of obesity in offspring exposed to overnutrition in early life.
Tatiane Aparecida Ribeiro, Laize Peron Tófolo, Isabela Peixoto Martins, Audrei Pavanello, Júlio Cezar de Oliveira, Kelly Valério Prates, Rosiane Aparecida Miranda, Claudinéia Conationi da Silva Franco, Rodrigo Mello Gomes, Flávio Andrade Francisco, Vander Silva Alves, Douglas Lopes de Almeida, Veridiana Mota Moreira, Kesia Palma-Rigo, Elaine Vieira, Gabriel Sergio Fabricio, Marcos Ricardo da Silva Rodrigues, Wilson Rinaldi, Ananda Malta, Paulo Cezar de Freitas Mathias   +19 more
doaj   +1 more source

Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs

eLife, 2017
Doc2B is a cytosolic protein with binding sites for Munc13 and Tctex-1 (dynein light chain), and two C2-domains that bind to phospholipids, Ca2+ and SNAREs.
Sébastien Houy, Alexander J Groffen, Iwona Ziomkiewicz, Matthijs Verhage, Paulo S Pinheiro, Jakob Balslev Sørensen   +5 more
doaj   +1 more source

Cystic Fibrosis of the Pancreas: The Role of CFTR Channel in the Regulation of Intracellular Ca2+ Signaling and Mitochondrial Function in the Exocrine Pancreas

Frontiers in Physiology, 2018
Cystic fibrosis (CF) is the most common genetic disorder that causes a significant damage in secretory epithelial cells due to the defective ion flux across the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.
Tamara Madácsy, Tamara Madácsy, Petra Pallagi, Jozsef Maleth, Jozsef Maleth, Jozsef Maleth   +5 more
doaj   +1 more source

Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release

eLife, 2020
Dopamine powerfully controls neural circuits through neuromodulation. In the vertebrate striatum, dopamine adjusts cellular functions to regulate behaviors across broad time scales, but how the dopamine secretory system is built to support fast and slow ...
Aditi Banerjee, Jinoh Lee, Paulina Nemcova, Changliang Liu, Pascal S Kaeser   +4 more
doaj   +1 more source

What are the Practices for Secret Management in Software Artifacts? [PDF]

arXiv, 2022
Throughout 2021, GitGuardian's monitoring of public GitHub repositories revealed a two-fold increase in the number of secrets (database credentials, API keys, and other credentials) exposed compared to 2020, accumulating more than six million secrets. A systematic derivation of practices for managing secrets can help practitioners in secure development.
arxiv