Results 41 to 50 of about 2,579,679 (405)
Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. [PDF]
, 2020 BackgroundThe trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how tau is released and transmitted, and how that is dysregulated in diseases ...
Arkin, Michelle +13 more
core
E-cadherin and cell adhesion: a role in architecture and function in the pancreatic islet [PDF]
, 2007 Background/Aims: The efficient secretion of insulin from beta-cells requires extensive intra-islet communication. The cell surface adhesion protein epithelial (E)-cadherin (ECAD) establishes and maintains epithelial tissues such as the islets of ...
Bamji SX +21 more
core +1 more source
Frontiers in Endocrinology, 2018 Pituitary adenylate cyclase activating polypeptide (PACAP) is a multifunctional neuropeptide with widespread occurrence throughout the body including the gastrointestinal system.
Dora Reglodi +6 more
doaj +1 more source
Bone & Joint Research, 2021 Aims: To investigate whether idiopathic osteonecrosis of the femoral head (ONFH) is related to impaired osteoblast activities. Methods: We cultured osteoblasts isolated from trabecular bone explants taken from the femoral head and the intertrochanteric ...
Leila Maestro-Paramio +3 more
doaj +1 more source
Regulation of bicarbonate secretion in marine fish intestine by the calcium-sensing receptor [PDF]
, 2018 In marine fish, high epithelial intestinal HCO3- secretion generates luminal carbonate precipitates of divalent cations that play a key role in water and ion homeostasis.
Fuentes, Juan, Gregorio, Silvia
core +2 more sources
Frontiers in Endocrinology, 2013 Pituitary gonadotrophs are a small fraction of the anterior pituitary population, yet they synthesize gonadotropins: luteinizing (LH) and follicle stimulating (FSH), essential for gametogenesis and steroidogenesis.
María Luisa eDurán-Pastén +1 more
doaj +1 more source
The secreted secret of PCSK9 [PDF]
Science-Business eXchange, 2009 Amgen researchers have demonstrated that blocking secreted PCSK9 in mice and nonhuman primates lowers LDL cholesterol. The findings bolster the case for an antibody-based approach to blocking the protein, which is a genetically validated target for hypercholesterolemia.
openaire +2 more sources
Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains [PDF]
, 2014 The Type VII protein secretion system, found in Gram-positive bacteria, secretes small proteins, containing a conserved W-x-G amino acid sequence motif, to the growth medium.
Cao, Zhen Ping +11 more
core +4 more sources
Small secreted proteins enable biofilm development in the cyanobacterium Synechococcus elongatus. [PDF]
, 2016 Small proteins characterized by a double-glycine (GG) secretion motif, typical of secreted bacterial antibiotics, are encoded by the genomes of diverse cyanobacteria, but their functions have not been investigated to date.
Golden, Susan +6 more
core +1 more source
Frontiers in Microbiology, 2010 Many pathogenic microbes, including many fungi, produce phospholipases which facilitate survival of the pathogen in vivo, invasion and dissemination throughout the host, expression of virulence traits and evasion of host immune defense mechanisms.
Julianne eDjordjevic
doaj +1 more source