Results 61 to 70 of about 2,034,530 (343)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Extracellular proteins: Novel key components of metal resistance in cyanobacteria?

Frontiers in Microbiology, 2016
Metals are essential for all living organisms and required for fundamental biochemical processes. However, when in excess, metals can turn into highly-toxic agents able to disrupt cell membranes, alter enzymatic activities and damage DNA.
Joaquin eGiner-Lamia, Joaquin eGiner-Lamia, Sara Bernardes Pereira, Sara Bernardes Pereira, Miquel eBovea-Marco, Matthias Erwin Futschik, Matthias Erwin Futschik, Paula eTamagnini, Paula eTamagnini, Paula eTamagnini, Paulo eOliveira, Paulo eOliveira   +11 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Membrane traffic and fusion at post-Golgi compartments

Frontiers in Plant Science, 2012
Complete sequencing of the Arabidopsis genome a decade ago has facilitated the functional analysis of various biological processes including membrane traffic by which many proteins are delivered to their sites of action and turnover.
Misoon ePark, Gerd eJürgens
doaj   +1 more source

Blood concentrations of small extracellular vesicles are determined by a balance between abundant secretion and rapid clearance

Journal of Extracellular Vesicles, 2020
Small extracellular vesicles (sEVs) are important mediators of cell–cell communication with respect to diverse physiological processes. To further understand their physiological roles, understanding blood sEV homoeostasis in a quantitative manner is ...
Akihiro Matsumoto, Yuki Takahashi, Hsin-Yi Chang, Yi-Wen Wu, Aki Yamamoto, Yasushi Ishihama, Yoshinobu Takakura   +6 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Presence and Effects of Pituitary Adenylate Cyclase Activating Polypeptide Under Physiological and Pathological Conditions in the Stomach

Frontiers in Endocrinology, 2018
Pituitary adenylate cyclase activating polypeptide (PACAP) is a multifunctional neuropeptide with widespread occurrence throughout the body including the gastrointestinal system.
Dora Reglodi, Anita Illes, Anita Illes, Balazs Opper, Eszter Schafer, Andrea Tamas, Gabriella Horvath   +6 more
doaj   +1 more source

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion.

Cell Reports, 2018
IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1-dependent GSDMD cleavage, which also induces pyroptosis.
Mercedes Monteleone, A. Stanley, Kaiwen W. Chen, Darren L. Brown, Jelena S. Bezbradica, J. V. von Pein, Caroline L. Holley, D. Boucher, Melanie R. Shakespear, R. Kapetanovic, Verena Rolfes, M. Sweet, J. Stow, K. Schroder   +13 more
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Erythropoietin-Mediated Secretion of Transforming Growth Factor β1 by Bone Marrow Mononuclear Cells is Negatively Regulated by Granulocytes via Secretion of Erythropoietin Receptors in the Milieu. [PDF]

, 2021
Vaijayanti Kale
openalex   +1 more source