Results 71 to 80 of about 2,579,679 (405)

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Diagnostic and referral pathways in patients with rare lipodystrophy and insulin-resistance syndromes: key milestones assessed from a national reference center

Orphanet Journal of Rare Diseases
Background Rare syndromes of lipodystrophy and insulin-resistance display heterogeneous clinical expressions. Their early recognition, diagnosis and management are required to avoid long-term complications.
Bruno Donadille, Sonja Janmaat, Héléna Mosbah, Inès Belalem, Sophie Lamothe, Mariana Nedelcu, Anne-Sophie Jannot, Sophie Christin-Maitre, Bruno Fève, Camille Vatier, Corinne Vigouroux   +10 more
doaj   +1 more source

Differentiation of Trafficking Pathways at Golgi Entry Core Compartments and Post-Golgi Subdomains

Frontiers in Plant Science, 2020
Eukaryotic cells have developed specialized membrane structures called organelles, which compartmentalize cellular functions and chemical reactions. Recent improvements in microscopy and membrane compartment isolation techniques are now sophisticating ...
Yoko Ito, Yohann Boutté
doaj   +1 more source

High-salinity growth conditions promote tat-independent secretion of tat substrates in Bacillus subtilis [PDF]

, 2012
The Gram-positive bacterium Bacillus subtilis contains two Tat translocases, which can facilitate transport of folded proteins across the plasma membrane. Previous research has shown that Tat-dependent protein secretion in B.
Alami, Antelmann, Antelmann, Barnett, Barnett, Berks, Bogsch, Bolhuis, Bongers, Bron, Bursy, Carmine G. Monteferrante, Chaddock, Cline, Colin Robinson, Cristobal, DeLisa, Driessen, Eijlander, Gasson, Harwood, Hoper, James P. Barnett, Jan Maarten van Dijl, Jongbloed, Jongbloed, Jongbloed, Jongbloed, Kolkman, Kouwen, Kouwen, Kunst, Lewis, Maillard, Meile, Meissner, Mendel, Muller, Natale, Nicolas, Palmer, Palmer, Panahandeh, Pommier, René van der Ploeg, Ridder, Robinson, Robinson, Sambrook, Sargent, Sjouke Piersma, Stanley, Thijs R. H. M. Kouwen, Tjalsma, Tjalsma, Tullman-Ercek, van der Ploeg, van Dijl, van Roosmalen, Yuan   +59 more
core   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane

Redox Biology, 2020
Hydrogen peroxide (H2O2) is an essential second intracellular messenger. To reach its targets in the cytosol, H2O2 must cross a membrane, a feat that requires aquaporins (AQP) endowed with ‘peroxiporin’ activity (AQP3, AQP8, AQP9).
Stefano Bestetti, Mauro Galli, Ilaria Sorrentino, Paolo Pinton, Alessandro Rimessi, Roberto Sitia, Iria Medraño-Fernandez   +6 more
doaj  

Unlocking the secrets of chitinase secretion [PDF]

Journal of Cell Biology, 2014
Researchers discover a new mechanism of protein secretion in a pathogenic bacterium.
openaire   +2 more sources

Class II ADP-ribosylation factors are required for efficient secretion of Dengue viruses [PDF]

, 2011
This article is available open access through the publisher’s website.Identification and characterization of virus-host interactions are very important steps toward a better understanding of the molecular mechanisms responsible for disease progression ...
Brault, JB, Bruzzone, R, Despre, P, Kudelko, M, Kwok, K, Li, MY, Nal, B, Pardigon, N, Peiris, JSM, Wang, PG   +9 more
core   +3 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Tau Secretion: Good and Bad for Neurons

Frontiers in Neuroscience, 2019
In Alzheimer’s disease (AD), neurofibrillary tangles (NFTs), lesions composed of hyperphosphorylated and aggregated tau, spread from the transentorhinal cortex to the hippocampal formation and neocortex.
Camille Pernègre, Camille Pernègre, Antoine Duquette, Antoine Duquette, Nicole Leclerc, Nicole Leclerc   +5 more
doaj   +1 more source