Results 81 to 90 of about 2,034,530 (343)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Ultrastructure and oil secretion in Hiptage sericea Hook
Acta Societatis Botanicorum Poloniae, 2014 The oil secreting glands of Hiptage sericea Hook. consist of three regions: epithelial, sub-epithelial and sub-glandular. In early stages, the oil secreting cells are characterized by the presence of plastids with starch grains and electron translucent ...
K. Arumugasamy +3 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Lipoproteins in a nonrecirculating perfusate of rat liver
Journal of Lipid Research, 1974 Rat livers were perfused in a nonrecirculating system for 30–40 min with Krebs-Ringer bicarbonate–0.1% glucose solution gassed with 95% O2–5% CO2 at 37°C at a flow rate of 3 ml/g/min.
Julian B. Marsh
doaj +1 more source
EMBO Molecular Medicine, 2020 Progressive myoclonus epilepsy (PME) of Unverricht–Lundborg type (EPM1) is an autosomal recessive neurodegenerative disorder with the highest incidence of PME worldwide.
Francesco Di Matteo +15 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Mechanisms controlling pancreatic islet cell function in insulin secretion
Nature reviews. Molecular cell biology, 2021 Jonathan E. Campbell, C. Newgard
semanticscholar +1 more source
Unconventional secretion of annexins and galectins
Seminars in Cell and Developmental Biology, 2018 Eukaryotic cells have a highly evolved system of protein secretion, and dysfunction in this pathway is associated with many diseases including cancer, infection, metabolic disease and neurological disorders.
Stephanie J Popa +2 more
semanticscholar +1 more source