Results 81 to 90 of about 2,802,374 (388)

Microfluidics-based liquid chromatography/mass spectrometry multiple reaction monitoring approach for the relative quantification of Burkholderia cenocepacia secreted virulence factors [PDF]

, 2018
Rationale: Burkholderia cenocepacia is an opportunistic pathogen that is commonly isolated from patients with cystic fibrosis (CF). Quorum sensing has been suggested to play a role in the activity of type II and type VI secretion systems and the release ...
Daled, Simon, De Waele, Stijn, Deforce, Dieter, Depluverez, Sofie, Devreese, Bart, Planckaert, Sören, Schoovaerts, Jolien   +6 more
core   +2 more sources

Tumor microenvironment induces innate RAF-inhibitor resistance through HGF secretion

Nature, 2012
Drug resistance presents a challenge to the treatment of cancer patients. Many studies have focused on cell-autonomous mechanisms of drug resistance. By contrast, we proposed that the tumour micro-environment confers innate resistance to therapy. Here we
R. Straussman, Teppei Morikawa, K. Shee, Michal Barzily-Rokni, Z. Qian, Jinyan Du, Ashli Davis, Margaret M. Mongare, Joshua Gould, Dennie T. Frederick, Z. Cooper, P. Chapman, D. Solit, A. Ribas, R. Lo, K. Flaherty, S. Ogino, J. Wargo, T. Golub   +18 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion. [PDF]

, 2012
The actin cortex both facilitates and hinders the exocytosis of secretory granules. How cells consolidate these two opposing roles was not well understood. Here we show that antigen activation of mast cells induces oscillations in Ca(2+) and PtdIns(4,5)P(
Meyer, T, Wollman, R
core   +1 more source

Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion

Nature Communications, 2019
Extracellular phosphate regulates its own renal excretion by eliciting concentration-dependent secretion of parathyroid hormone (PTH). However, the phosphate-sensing mechanism remains unknown and requires elucidation for understanding the aetiology of ...
Patricia P. Centeno, A. Herberger, Hee‐chang Mun, C. Tu, E. Nemeth, Wenhan Chang, A. Conigrave, D. Ward   +7 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Response of the tegument of Fasciola hepatica to infection and immunization sera in vitro

Parasitology
The migratory phase is a critical time for Fasciola hepatica as it must locate, penetrate and migrate through the alimentary tract to the liver parenchyma whilst under attack from the host immune response.
Clive E. Bennett, Adam P.S. Bennett, Robert E.B. Hanna, Mark W. Robinson   +3 more
doaj   +1 more source

The structure of some floral elements and the nectar production rate of Polemonium caeruleum L.

Acta Agrobotanica, 2012
The present study, carried out in the period 2008 - 2009, covered some morphological and anatomical features of the flowers of Polemonium caeruleum L. and their nectar production rate in the climatic conditions of the Lublin region.
Mirosława Chwil
doaj   +1 more source

Structure of HrcQ(B)-C, a conserved component of the bacterial type III secretion systems [PDF]

, 2003
Type III secretion systems enable plant and animal bacterial pathogens to deliver virulence proteins into the cytosol of eukaryotic host cells, causing a broad spectrum of diseases including bacteremia, septicemia, typhoid fever, and bubonic plague in ...
A. P. Tampakaki, Alfano, Anderson, Br  nger, Charkowski, Collmer, Fadouloglou, Francis, Galan, Garcia de la Torre, Gouet, Hueck, J. M. Hadden, Jin, Kubori, Landgraf, Lloyd, Luo, M. Kokkinidis, M. N. Bastaki, Mathews, McGuffin, Murshudov, N. J. Panopoulos, N. M. Glykos, Rossier, S. E. Phillips, Stebbins, Tamano, Tang, Terwilliger, Terwilliger, V. E. Fadouloglou, Zhao   +33 more
core   +2 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source