Growth Factor-Primed WJ-MSC Secretome Enhances Fibroblast Expansion In Vitro [PDF]
BiomedicinesBackground: In regenerative medicine, there is interest in using acellular therapy based on the secretome of mesenchymal stem cells (MSC) to promote wound healing. Wharton’s jelly cells (WJ-MSCs) are a readily available source.
Katia Jarquín-Yáñez +8 more
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Contribution of Extracellular Membrane Vesicles To the Secretome of Staphylococcus aureus
mBio, 2023 The microbial secretome modulates how the organism interacts with its environment. Included in the Staphylococcus aureus secretome are extracellular membrane vesicles (MVs) that consist of cytoplasmic and membrane proteins, as well as exoproteins, some ...
Divakara SSM Uppu +2 more
doaj +1 more source
Acoustofluidic Interfaces for the Mechanobiological Secretome of MSCs
Nature Communications, 2023 While mesenchymal stem cells (MSCs) have gained enormous attention due to their unique properties of self-renewal, colony formation, and differentiation potential, the MSC secretome has become attractive due to its roles in immunomodulation, anti ...
Ye He +13 more
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Stem Cell’s Secretome Delivery Systems [PDF]
Advanced Pharmaceutical Bulletin, 2023 Stem cells’ secretome contains biomolecules that are ready to give therapeutic activities. However, the biomolecules should not be administered directly because of their in vivo instability.
Abd. Kakhar Umar
doaj +1 more source
Effects of secretome on cisplatin-induced testicular dysfunction in rats [PDF]
Veterinary World, 2018 Background: Testicular dysfunction is a degenerative disorder characterized by failure in the synthesis of reproductive hormones and spermatogenesis. Secretome derived from the human umbilical mesenchymal stem cell (MSC) has been reported to repair some ...
Surya Agus Prihatno +6 more
doaj +1 more source
Redox proteomics of the inflammatory secretome identifies a common set of redoxins and other glutathionylated proteins released in inflammation, influenza virus infection and oxidative stress [PDF]
, 2015 Protein cysteines can form transient disulfides with glutathione (GSH), resulting in the production of glutathionylated proteins, and this process is regarded as a mechanism by which the redox state of the cell can regulate protein function. Most studies
A Erroi +82 more
core +6 more sources
The anti-fibrotic effect of human fetal skin-derived stem cell secretome on the liver fibrosis
Stem Cell Research & Therapy, 2020 Background Liver fibrosis resulting from chronic liver injury is one of the major causes of mortality worldwide. Stem cell-secreted secretome has been evaluated for overcoming the limitations of cell-based therapy in hepatic disease, while maintaining ...
Xia Yao +3 more
doaj +1 more source
Decoding the byssus fabrication by spatiotemporal secretome analysis of scallop foot
Computational and Structural Biotechnology Journal, 2022 Secretome is involved in almost all physiological, developmental, and pathological processes, but to date there is still a lack of highly-efficient research strategy to comprehensively study the secretome of invertebrates.
Xiaoting Dai +12 more
doaj +1 more source
Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]
, 2020 Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A. +11 more
core +1 more source
Stem Cell Research & Therapy, 2021 Background Mesenchymal stromal cells (MSCs) have been introduced as promising cell source for regenerative medicine. Besides their multilineage differentiation capacity, MSCs release a wide spectrum of bioactive factors.
Sebastian Wangler +11 more
doaj +1 more source