Results 91 to 100 of about 61,645 (272)

Effects of Adipose-Derived Mesenchymal Stem Cell-Secretome on Pyroptosis of Laparoscopic Hepatic Ischemia Reperfusion Injury in a Porcine Model

Cells
Extensive research has been conducted on mesenchymal stem cells (MSCs) regarding their ability to modify the immune response and reduce tissue damage. Many researchers have found that the regulatory capacity of MSCs primarily comes from their secretome ...
Yajun Ma, Lei Cao, Pujun Li, Zhihui Jiao, Xiaoning Liu, Xiangyu Lu, Tao Liu, Hongbin Wang   +7 more
doaj   +1 more source

Proteone and secretome of trypanosomes : A standardised analytical method [PDF]

, 2007
During the infection in mammals, the trypanosomes are known to develop strategies to escape host immune responses that are responsible for the immunopathology.
Brizard, Jean-Paul, Courtois, Pierrette, Cuny, Gérard, Daulouède, Sylvie, Frutos, Roger, Grébaut, Pascal, Holzmuller, Philippe, Vincendeau, Philippe   +7 more
core  

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, EarlyView.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source

MACL-1 Breast Cancer Secretome Reprograms Fibroblasts to Enhance Inflammation and Tumor Progression [PDF]

Anais da Academia Brasileira de Ciências
Tumor-secreted factors reprogram the stromal microenvironment to facilitate cancer progression. This study investigates the effects of the MACL-1 breast cancer cell secretome on CCD19-Lu fibroblasts.
RODRIGO JUNIO R. BARROS, ANDREIA LAURA P. RODRIGUES, CAMILA DOURADO, LUCIANA MARIA SILVA, JONAS ENRIQUE A. PERALES, SANDRA LAUTON-SANTOS, ANDREIA BARROSO, JADER S. CRUZ   +7 more
doaj   +1 more source

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF

Scientific Reports, 2017
Mesenchymal stem cells (MSCs) have been used for cell-based therapies in regenerative medicine, with increasing importance in central and peripheral nervous system repair.
Luís F. Martins, Rui O. Costa, Joana R. Pedro, Paulo Aguiar, Sofia C. Serra, Fabio G. Teixeira, Nuno Sousa, António J. Salgado, Ramiro D. Almeida   +8 more
doaj   +1 more source

Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and Animal behavior in a Rat Model of Parkinson’s Disease [PDF]

, 2017
Research in the last decade strongly suggests that mesenchymal stem cell (MSC)-mediated therapeutic benefits are mainly due to their secretome, which has been proposed as a possible therapeutic tool for the treatment of Parkinson's disease (PD).
Allen, Altuğ, Anisimov, Anjo, Baquet, Bibbiani, Boix, Bouchez, Campos, Carvalho, Castrioto, Cerri, Chao, Cova, D'Adamio, d'Anglemont de Tassigny, de la Fuente-Fernández, Drago, Du, Falk, Febbraro, Fu, Fujii, Hirano, Hoban, Hoffmann, Jin, Kirik, Levy, Lindvall, McCoy, Miller, Montoya, Monville, Müller, Müller, Nonaka, Nordera, Olanow, Olanow, Paul, Paxinos, Poewe, Pucci, Ramaswamy, Sadan, Sadan, Sadan, Santini, Sennels, Singh, Stahl, Tabrez, Takeda, Tang, Teixeira, Teixeira, Teixeira, Teixeira, Thompson, Torres, Trenkwalder, Truong, Venkataramana, Volkmann, Wang, Wang, Weiner, Weiner, Weiss, Xiong, Yabe, Yasuda, Yasuhara, Yasuhara   +74 more
core   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Bioprocessing of Mesenchymal Stem Cells and Their Derivatives: Toward Cell-Free Therapeutics

Stem Cells International, 2018
Mesenchymal stem cells (MSCs) have attracted tremendous research interest due to their ability to repair tissues and reduce inflammation when implanted into a damaged or diseased site.
Jolene Phelps, Amir Sanati-Nezhad, Mark Ungrin, Neil A. Duncan, Arindom Sen   +4 more
doaj   +1 more source