Results 151 to 160 of about 61,645 (272)

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

iNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang, Shuang Wu, Shuangbiao Wei, Weizhen Xiang, Jianshang Huang, Lei Xiong, Hua Wang, Li Zuo   +7 more
wiley   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

Mesenchymal stem cells modulate breast cancer progression through their secretome by downregulating ten-eleven translocation 1

Scientific Reports
Mesenchymal stem cells (MSCs) have emerged as crucial players within the tumor microenvironment (TME), contributing through their paracrine secretome. Depending on the context, the MSC-derived secretome can either support or inhibit tumor growth.
Romina Motamed, Keyvan Jabbari, Mahboubeh Sheikhbahaei, Mohammad H. Ghazimoradi, Sara Ghodsi, Motahareh Jahangir, Neda Habibi, Sadegh Babashah   +7 more
doaj   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

A DUF3455 domain‐containing protein promotes Ustilaginoidea virens infection and functions as a plant immune elicitor

New Plant Protection, EarlyView.
The fungal effector UvDUF1 from Ustilaginoidea virens not only promotes infection but also acts as a plant immunity elicitor, inducing broad‐spectrum disease resistance in rice and Nicotiana benthamiana. These results reveal its potential as a novel target for sustainable crop protection strategies.
Shuchen Wang, Wen Zhang, Wenyue Zheng, Qian Zhang, Mina Yu, Junjie Yu, Huijuan Cao, Xiayan Pan, Zhongqiang Qi, Yan Du, Rongsheng Zhang, Yunpeng Wang, Yongfeng Liu, Tianqiao Song   +13 more
wiley   +1 more source

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells (PSCs) and consequent development of dense stroma are prominent features ...
Antal, Corina E, Atkins, Annette R, Becerra, Carlos R, Borazanci, Erkut, Collisson, Eric A, Dann, Amanda M, DelGiorno, Kathleen E, Donahue, Timothy R, Downes, Michael, Erikson, Galina, Evans, Ronald M, Fang, Linjing, Gao, Weina, Grandgenett, Paul M, Hollingsworth, Michael A, Huang, Peiwu, Hunter, Tony, Leblanc, Mathias, Liang, Gaoyang, Lowy, Andrew M, Lytle, Nikki K, Manor, Uri, Meisenhelder, Jill, Pawson, Tony, Reya, Tannishtha, Ridinger-Saison, Maya, Santisakultarm, Thom P, Scadeng, Miriam, Shi, Yu, Sun, Huaiyu, Terenziani, Elena, Tian, Ruijun, Umetsu, Sarah E, Von Hoff, Daniel D, Wahl, Geoffrey M, Woo, Gyunghwi, Xu, Ruilian, Yuan, Xiao   +37 more
core  

SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies

PROTEOMICS, EarlyView.
ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà, Loredana Leggio, Greta Paternò, Elena Giusto, Laura Civiero, Vincenzo Cunsolo, Silvia Vivarelli, Antonella Di Francesco, Emanuele Alpi, Nunzio Iraci, Rosaria Saletti   +10 more
wiley   +1 more source

Metabolic engineering of adipose‐derived stem cell exosomes via arachidonic acid potentiates diabetic wound repair by orchestrating angiogenesis: A multi‐omics guided strategy

VIEW, EarlyView.
AA‐Exos promotes angiogenesis and accelerates diabetic wound healing by activating the PI3K/AKT/mTOR pathway. Abstract Diabetic wounds are common and challenging complications of diabetes, characterized by delayed healing and an increased risk of infection.
Yujiao Cai, Jinnan Wang, Yan Liu, Xiaoke Zhu, Zhanyuan Yuan, Weiling Li, Dehui Che, Dongsheng Cao   +7 more
wiley   +1 more source

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

Size-dependent immunomodulation by MSC secretome: soluble factors target innate pathways, components larger than 100 kDa regulate T cell proliferation

Stem Cell Research & Therapy
Background Mesenchymal stromal cells exert their immunoregulatory effects through a complex secretome constituted of soluble factors and extracellular vesicles (EVs).
Christophe Wong, Isaure Rous, Shony Lemieux, Jeanne Volatron, Nassima Bekaddour, Thibaut Fourniols, Jean-Philippe Herbeuval   +6 more
doaj   +1 more source