Advanced Science, EarlyView.Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao +11 more
wiley +1 more source
Brain-Derived Neurotrophic Factor Trafficking via the Regulated Secretory Pathway: Mechanisms and Disease Implications. [PDF]
Mol NeurobiolEwell SN.
europepmc +1 more source
Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2. [PDF]
Nat Commun, 2023 Nalbach K +9 more
europepmc +1 more source
Probing for quality control in the early secretory pathway
, 2003 Annarosa Mezzacasa
openalex +1 more source
The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis
Advanced Science, EarlyView.SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo +5 more
wiley +1 more source
The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasis. [PDF]
Front Cell Dev Biol, 2022 Roberts BS, Satpute-Krishnan P.
europepmc +1 more source
The secretory pathway of protists: spatial and functional organization and evolution.
, 1996 Burkhard Becker, Michael Melkonian
openalex +1 more source
Advanced Science, EarlyView.This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi +11 more
wiley +1 more source
TUG protein acts through a disordered region to organize the early secretory pathway. [PDF]
Nat CommunParchure A +12 more
europepmc +1 more source
Impact of interorganelle coordination between the conventional early secretory pathway and autophagy in cellular homeostasis and stress response. [PDF]
Front Cell Dev Biol, 2023 Tapia D +3 more
europepmc +1 more source