Results 171 to 180 of about 321,020 (307)

A reconstruction of the mammalian secretory pathway identifies mechanisms regulating antibody production. [PDF]

Cell Syst
Masson H, Tat J, Di Giusto P, Antonakoudis A, Shamie I, Baghdassarian H, Samoudi M, Robinson CM, Kuo CC, Koga N, Singh S, Gezalyan A, Li Z, Movsessian A, Richelle A, Lewis NE.   +15 more
europepmc   +1 more source

The Early Secretory Pathway Is Crucial for Multiple Aspects of the Hepatitis C Virus Life Cycle. [PDF]

J Virol, 2023
Avula K, Singh B, Samantaray S, Syed GH.
europepmc   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

A regulatory circuit operated by KDELR1 and KDELR3 fine-tunes the composition of the early secretory pathway. [PDF]

Cell Mol Life Sci
Palazzo FC, Dalla Torre M, Amagai Y, Han X, Tempio T, Valetti C, Manteiga JG, Matsumoto M, Feige M, Sallese M, Inaba K, Sitia R, Anelli T.   +12 more
europepmc   +1 more source

Regulation of secretory pathway kinase or kinase-like proteins in human cancers. [PDF]

Front Immunol, 2023
Du S, Zhu C, Ren X, Chen X, Cui X, Guan S.   +5 more
europepmc   +1 more source

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Engineering receptors in the secretory pathway for orthogonal signalling control. [PDF]

Nat Commun, 2022
Mahameed M, Wang P, Xue S, Fussenegger M.   +3 more
europepmc   +1 more source

Comprehensive Analysis of the Putative Substratome of FAM20C, the Master Serine Kinase of the Secretory Pathway. [PDF]

Biomolecules
Cesaro L, Noventa F, De Los Angeles Cordero T, Molon B, Bosello Travain V, Aspromonte MC, Salvi M.   +6 more
europepmc   +1 more source

Novel secretory pathway pumps

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
Poulsen, Lisbeth Rosager, López-Marqués, Rosa Laura, Sørensen, Danny Mollerup, Pomorski, Thomas, Pedersen, Morten Buch, Palmgren, Michael Gjedde   +5 more
openaire   +1 more source