Results 41 to 50 of about 321,020 (307)

Comprehensive Insight into Tapetum-Mediated Pollen Development in Arabidopsis thaliana

Cells, 2023
In flowering plants, pollen development is a key process that is essential for sexual reproduction and seed set. Molecular and genetic studies indicate that pollen development is coordinatedly regulated by both gametophytic and sporophytic factors ...
Shuaijie Wei, Ligeng Ma
doaj   +1 more source

SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. [PDF]

, 2013
The secretory pathway of eukaryotic cells packages cargo proteins into COPII-coated vesicles for transport from the endoplasmic reticulum (ER) to the Golgi.
Adams, Elizabeth, Bai, Yongsheng, Baines, Andrea, Bajaj, Kanika, Chen, Xiao-Wei, Ginsburg, David, Lin, Jiandie, Liu, Hui-Hui, Ma, Danjun, Meng, Zhuo-Xian, Sartor, Maureen A, Schekman, Randy, Wang, He, Yi, Zhengping, Young, Stephen G, Yu, Genggeng, Zhang, Bin, Zhang, Pengcheng   +17 more
core   +1 more source

Imbalance of heterologous protein folding and disulfide bond formation rates yields runaway oxidative stress

BMC Biology, 2012
Background The protein secretory pathway must process a wide assortment of native proteins for eukaryotic cells to function. As well, recombinant protein secretion is used extensively to produce many biologics and industrial enzymes. Therefore, secretory
Tyo Keith EJ, Liu Zihe, Petranovic Dina, Nielsen Jens   +3 more
doaj   +1 more source

Coxsackievirus A10 blocks autophagosome-lysosome fusion to promote viral nonlytic spread and inflammatory cytokine release

Microbiology Spectrum
We aimed to demonstrate whether coxsackievirus A10 (CV-A10) perturbed the fusion between autophagosomes and lysosomes to cause viral nonlytic spread and inflammatory cytokine release at the blood-brain barrier (BBB), thereby contributing to ...
Ruibin Wang, Hui Li, Lin Zhu, Yuping Zhang, Rongxia Zuo, Chen Liu, Jie Song, Yajie Hu   +7 more
doaj   +1 more source

Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation

Nature Communications, 2020
Alternative polyadenylation generates multiple mRNA isoforms with different 3′ UTR sizes. Here the authors report global 3′ UTR shortening that is coupled to increased expression of secretory pathway genes in secretory cell differentiation.
Larry C. Cheng, Dinghai Zheng, Erdene Baljinnyam, Fangzheng Sun, Koichi Ogami, Percy Luk Yeung, Mainul Hoque, Chi-Wei Lu, James L. Manley, Bin Tian   +9 more
doaj   +1 more source

Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis

eLife, 2023
The Rab27 effectors are known to play versatile roles in regulated exocytosis. In pancreatic beta cells, exophilin-8 anchors granules in the peripheral actin cortex, whereas granuphilin and melanophilin mediate granule fusion with and without stable ...
Kunli Zhao, Kohichi Matsunaga, Kouichi Mizuno, Hao Wang, Katsuhide Okunishi, Tetsuro Izumi   +5 more
doaj   +1 more source

Eimeria tenella protein trafficking: differential regulation of secretion versus surface tethering during the life cycle [PDF]

, 2017
Eimeria spp. are intracellular parasites that have a major impact on poultry. Effective live vaccines are available and the development of reverse genetic technologies has raised the prospect of using Eimeria spp.
Blake, D P, Crouch, C, Long, E, Marugan-Hernandez, V, Tomley, F M   +4 more
core   +1 more source

A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation

eLife, 2014
Nutritional restriction leads to protein translation attenuation that results in the storage and degradation of free mRNAs in cytoplasmic assemblies. In this study, we show in Drosophila S2 cells that amino-acid starvation also leads to the inhibition of
Margarita Zacharogianni, Angelica Aguilera-Gomez, Tineke Veenendaal, Jan Smout, Catherine Rabouille   +4 more
doaj   +1 more source

Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of glycosyl hydrolases [PDF]

, 2013
Background: Ascaris lumbricoides and Ascaris suum are socioeconomically important and widespread parasites of humans and pigs, respectively. The excretory-secretory (ES) molecules produced and presented at the parasite-host interface during the different
Deforce, Dieter, Dhaenens, Maarten, Gasser, Robin B, Geldhof, Peter, Jex, Aaron R, Van Steendam, Katleen, Vlaminck, Johnny, Wang, Tao   +7 more
core   +5 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source