Results 51 to 60 of about 1,228,008 (299)

A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation

eLife, 2014
Nutritional restriction leads to protein translation attenuation that results in the storage and degradation of free mRNAs in cytoplasmic assemblies. In this study, we show in Drosophila S2 cells that amino-acid starvation also leads to the inhibition of
Margarita Zacharogianni, Angelica Aguilera-Gomez, Tineke Veenendaal, Jan Smout, Catherine Rabouille   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Secretory pathway antagonism by calicivirus homologues of Norwalk virus nonstructural protein p22 is restricted to noroviruses

Virology Journal, 2012
Background Our previous report that the Norwalk virus nonstructural protein p22 is an antagonist of the cellular secretory pathway suggests a new aspect of norovirus/host interaction.
Sharp Tyler M, Crawford Sue E, Ajami Nadim J, Neill Frederick H, Atmar Robert L, Katayama Kazuhiko, Utama Budi, Estes Mary K   +7 more
doaj   +1 more source

Carbohydrate- and conformation-dependent cargo capture for ER-exit [PDF]

, 2005
Some secretory proteins leave the endoplasmic reticulum (ER) by a receptor-mediated cargo capture mechanism, but the signals required for the cargo-receptor interaction are largely unknown.
Appenzeller-Herzog, C., Lopez-Otin, C., Santamaria, I., Nyfeler, B., Burkhard, P., Hauri, H. -P.   +5 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

An integrated approach to infer cross-talks between intracellular protein transport and signaling pathways

BMC Bioinformatics, 2018
Background The endomembrane system, known as secretory pathway, is responsible for the synthesis and transport of protein molecules in cells. Therefore, genes involved in the secretory pathway are essential for the cellular development and function ...
Kumar Parijat Tripathi, Marina Piccirillo, Mario Rosario Guarracino   +2 more
doaj   +1 more source

Combining manipulation of integration loci and secretory pathway on expression of an Aspergillus niger glucose oxidase gene in Trichoderma reesei

Microbial Cell Factories, 2023
Trichoderma reesei (T. reesei) is well-known for its excellent ability to secret a large quantity of cellulase. However, unlike the endogenous proteins, little is known about the molecular mechanisms governing heterologous protein production.
Wangli Ji, Xiaolu Wang, Xiaoqing Liu, Yuan Wang, Fangui Liu, Bo Xu, Huiying Luo, Tao Tu, Wei Zhang, Xinxin Xu, Xiaoyun Su   +10 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An amphipathic alpha-helix in the prodomain of cocaine and amphetamine regulated transcript peptide precursor serves as its sorting signal to the regulated secretory pathway. [PDF]

PLoS ONE, 2013
Cocaine and Amphetamine Regulated Transcript (CART) peptides are anorexigenic neuropeptides. The L34F mutation in human CART peptide precursor (proCART) has been linked to obesity (Yanik et al. Endocrinology 147: 39, 2006).
Elías H Blanco, Carlos F Lagos, María Estela Andrés, Katia Gysling   +3 more
doaj   +1 more source

Unique Endomembrane Systems and Virulence in Pathogenic Protozoa

Life, 2021
Virulence in pathogenic protozoa is often tied to secretory processes such as the expression of adhesins on parasite surfaces or the secretion of proteases to assisted in tissue invasion and other proteins to avoid the immune system.
Mark F. Wiser
doaj   +1 more source