Results 41 to 50 of about 1,228,008 (299)
Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis
eLife, 2023 The Rab27 effectors are known to play versatile roles in regulated exocytosis. In pancreatic beta cells, exophilin-8 anchors granules in the peripheral actin cortex, whereas granuphilin and melanophilin mediate granule fusion with and without stable ...
Kunli Zhao +5 more
doaj +1 more source
The Secretory Pathway and Neuron Polarization [PDF]
The Journal of Neuroscience, 2006 The growth of dendrites and axons is accompanied by an enormous increase in cell surface area. A cultured hippocampal neuron that has grown for 7 d in vitro can have ∼250 μm of dendrites and 3000 μm of axons.
Bing, Ye +3 more
openaire +2 more sources
BMC Biology, 2012 Background The protein secretory pathway must process a wide assortment of native proteins for eukaryotic cells to function. As well, recombinant protein secretion is used extensively to produce many biologics and industrial enzymes. Therefore, secretory
Tyo Keith EJ +3 more
doaj +1 more source
Microbiology SpectrumWe aimed to demonstrate whether coxsackievirus A10 (CV-A10) perturbed the fusion between autophagosomes and lysosomes to cause viral nonlytic spread and inflammatory cytokine release at the blood-brain barrier (BBB), thereby contributing to ...
Ruibin Wang +7 more
doaj +1 more source
A secretory kinase complex regulates extracellular protein phosphorylation
eLife, 2015 Although numerous extracellular phosphoproteins have been identified, the protein kinases within the secretory pathway have only recently been discovered, and their regulation is virtually unexplored.
Jixin Cui +5 more
doaj +1 more source
Nature Communications, 2020 Alternative polyadenylation generates multiple mRNA isoforms with different 3′ UTR sizes. Here the authors report global 3′ UTR shortening that is coupled to increased expression of secretory pathway genes in secretory cell differentiation.
Larry C. Cheng +9 more
doaj +1 more source
Influence of the purification of human adult pancreatic islets on insulin secretion [PDF]
Vojnosanitetski Pregled, 2010 Background/Aim. The most effective method for human adult pancreatic islets purification is density-gradient centrifugation. The aim of this study was to analyze the effects of non-automated purification on preservation of functional capacity of human ...
Nikolić Dragan M. +5 more
doaj +1 more source
Calcium/sodium exchange in purified secretory vesicles from bovine neurohypophyses [PDF]
, 1983 Purified secretory vesicles isolated from bovine neurohypophyses take up Na+ under the same circumstances where an efflux of Ca2+ takes place, suggesting a Na+/Ca2+ exchange. Potassium cannot substitute for Na+ in this process. Also, a Ca2+/Ca2+ exchange
Thorn, N. A. +2 more
core +1 more source
Shotgun proteomics of Aspergillus niger microsomes upon D-xylose induction [PDF]
, 2010 Protein secretion plays an eminent role in cell maintenance and adaptation to the extracellular environment of microorganisms. Although protein secretion is an extremely efficient process in filamentous fungi, the mechanisms underlying protein secretion ...
Graaff, L.H., de +3 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source