Incomplete posttranslational prohormone modifications in hyperactive neuroendocrine cells
BMC Cell Biology, 2009 Background In black-background-adapted Xenopus laevis, the intermediate pituitary melanotrope cells are hyperactive, producing large amounts of their major secretory cargo proopiomelanocortin (POMC, representing ~80% of all newly synthesised proteins ...
Martens Gerard JM, Strating Jeroen RPM
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A single polar residue and distinct membrane topologies impact the function of the infectious bronchitis coronavirus E protein. [PDF]
PLoS Pathogens, 2012 The coronavirus E protein is a small membrane protein with a single predicted hydrophobic domain (HD), and has a poorly defined role in infection. The E protein is thought to promote virion assembly, which occurs in the Golgi region of infected cells. It
Travis R Ruch, Carolyn E Machamer
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Rab3D is critical for secretory granule maturation in PC12 cells. [PDF]
, 2013 Neuropeptide- and hormone-containing secretory granules (SGs) are synthesized at the trans-Golgi network (TGN) as immature secretory granules (ISGs) and complete their maturation in the F-actin-rich cell cortex.
Sharon A. Tooze (391543) +36 more
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N-glycosylation Triggers a Dual Selection Pressure in Eukaryotic Secretory Proteins
Scientific Reports, 2017 Nearly one third of the eukaryotic proteome traverses the secretory pathway and most of these proteins are N-glycosylated in the lumen of the endoplasmic reticulum.
Máximo Lopez Medus +9 more
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Characterization of granule-like structures in non-endocrine cells [PDF]
, 2006 All eukaryotic cells have transport pathways to constitutively secrete proteins. Endocrine, neuroendocrine, and exocrine cells in addition have a regulated secretory pathway that serves the controlled release of hormones, neuropeptides or digestive ...
Stettler, Hansruedi
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From endoplasmic reticulum to secretory granules: role of zinc in the secretory pathway of growth hormone [PDF]
, 2012 Endocrine and neuroendocrine cells differ from cells which rapidly release all their secreted proteins in that they store some secretory proteins in concentrated forms in secretory granules to be rapidly released when cells are stimulated.
Vibor Petkovic +5 more
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Cell Reports, 2017 Summary: Ionotropic glutamate receptor (iGluR) trafficking and function underpin excitatory synaptic transmission and plasticity and shape neuronal networks.
Ashley J. Evans +4 more
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Processing of prothrombin in the secretory pathway [PDF]
Biochemical Journal, 1991 Antibodies raised against plasma prothrombin and the prothrombin propeptide were used to identify prothrombin precursors in rough and smooth microsomes and in the Golgi apparatus. The data demonstrate that the propeptide is part of the prothrombin molecule when undergoing a variety of modifications in the Golgi apparatus.
C, Stanton, R, Taylor, R, Wallin
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The c-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole [PDF]
, 2003 We have assessed the ability of the plant secretory pathway to handle the expression of complex heterologous proteins by investigating the fate of a hybrid immunoglobulin A/G in tobacco cells.
Santoro, Aniello +6 more
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Recent Developments in Deciphering the Biological Role of Plant Complex N-Glycans
Frontiers in Plant Science, 2022 Asparagine (N)-linked protein glycosylation is a ubiquitous co- and posttranslational modification which has a huge impact on the biogenesis and function of proteins and consequently on the development, growth, and physiology of organisms.
Richard Strasser
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