Results 31 to 40 of about 1,228,008 (299)
Mistargeting of the lectin ERGIC-53 to the endoplasmic reticulum of HeLa cells impairs the secretion of a lysosomal enzyme [PDF]
, 1998 ERGIC-53, a homo-oligomeric recycling protein associated with the ER-Golgi intermediate compartment (ERGIC), has properties of a mannose-selective lectin in vitro, suggesting that it may function as a transport receptor for glycoproteins in the early ...
Florence Vollenweider +7 more
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LRP1 modulates APP trafficking along early compartments of the secretory pathway
Neurobiology of Disease, 2008 The amyloid beta peptide (Aβ) is a central player in Alzheimer's disease (AD) pathology. Aβ liberation depends on APP cleavage by β- and γ-secretases. The low density lipoprotein receptor related protein 1 (LRP1) was shown to mediate APP processing at ...
Elaine Waldron +8 more
doaj +1 more source
Secretory vesicles are preferentially targeted to areas of low molecular SNARE density [PDF]
, 2012 Intercellular communication is commonly mediated by the regulated fusion, or exocytosis, of vesicles with the cell surface. SNARE (soluble N-ethymaleimide sensitive factor attachment protein receptor) proteins are the catalytic core of the secretory ...
Weiping Lu (120665) +32 more
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Plant Protein O-Arabinosylation
Frontiers in Plant Science, 2021 A wide range of proteins with diverse functions in development, defense, and stress responses are O-arabinosylated at hydroxyprolines (Hyps) within distinct amino acid motifs of continuous stretches of Hyps, as found in the structural cell wall extensins,
Bent Larsen Petersen +2 more
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Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast [PDF]
, 1999 In Saccharomyces cerevisiae, amino acid permeases are divided into two classes. One class, represented by the general amino acid permease GAP1, contains permeases regulated in response to the nitrogen source.
Hall, M. N. +5 more
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Comprehensive Insight into Tapetum-Mediated Pollen Development in Arabidopsis thaliana
Cells, 2023 In flowering plants, pollen development is a key process that is essential for sexual reproduction and seed set. Molecular and genetic studies indicate that pollen development is coordinatedly regulated by both gametophytic and sporophytic factors ...
Shuaijie Wei, Ligeng Ma
doaj +1 more source
Journal of Pharmacological Sciences, 2004 To examine the unknown trafficking pathway of the cystic fibrosis transmembrane conductance regulator (CFTR) from the endoplasmic reticulum (ER), we utilized baby hamster kidney cells stably expressing CFTR fused with green fluorescent protein.
Tsukasa Okiyoneda +8 more
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Fusion of secretory vesicles isolated from rat liver [PDF]
, 1978 Secretory vesicles isolated from rat liver were found to fuse after exposure to Ca2+. Vescle fusion is characterized by the occurrence of twinned vesicles with a continuous cleavage plane between two vesicles in freeze-fracture electron microscopy.
Dahl, Gerhard +2 more
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Zinc regulates ERp44-dependent protein quality control in the early secretory pathway
Nature Communications, 2019 Zinc ions (Zn2+) are imported by Golgi-resident transporters but the function of zinc in the early secretory pathway has remained unknown. Here the authors find that Zn2+ regulates protein quality control in the early secretory pathway by demonstrating ...
Satoshi Watanabe +10 more
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Molecular insights into the transport lectin function of ERGIC-53 [PDF]
, 2004 Secretion of proteins is an essential function of eukaryotic cells. The secretory proteins’ journey along the organelles of the exocytic pathway is initiated by the exit from the endoplasmic reticulum (ER), which defines a major rate-limiting step for ...
Appenzeller-Herzog, Christian
core +1 more source