Voltage Sensing in Bacterial Protein Translocation [PDF]
Biomolecules, 2020 The bacterial channel SecYEG efficiently translocates both hydrophobic and hydrophilic proteins across the plasma membrane. Translocating polypeptide chains may dislodge the plug, a half helix that blocks the permeation of small molecules, from its ...
Denis G. Knyazev +5 more
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Structure of the substrate-engaged SecA-SecY protein translocation machine [PDF]
Nature Communications, 2019 Proteins are translocated across membranes through the Sec61/SecY channel. Here, the authors present the structure of a translocating peptide chain trapped inside the SecA-SecY complex which suggests how peptides are actively moved through the channel.
Chengying Ma +7 more
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Specific biomarker mining and rapid detection of Burkholderia cepacia complex by recombinase polymerase amplification [PDF]
Frontiers in Microbiology, 2023 ObjectiveTo mine specific proteins and their protein-coding genes as suitable molecular biomarkers for the Burkholderia cepacia Complex (BCC) bacteria detection based on mega analysis of microbial proteomic and genomic data comparisons and to develop a ...
Yiling Fan +10 more
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Canine Leptospirosis in Flood-Affected Areas of Southern Brazil: Molecular Assessment and Public Health Implications [PDF]
Infectious Disease ReportsBackground: Southern Brazil faced massive rains and floods in May 2024, which led to social, infrastructural, and One Health issues affecting over 478 municipalities and 2.3 million people.
Gabriela Merker Breyer +10 more
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Leptospirosis outbreak in Ecuador in 2023: A pilot study for surveillance from a One Health perspective [PDF]
One HealthLeptospirosis is a neglected zoonotic disease that is endemic in tropical regions, including Ecuador. It is caused by spirochetes of the genus Leptospira, which can infect humans through animal reservoirs such as rats and dogs, or through contact with ...
Solón Alberto Orlando +26 more
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Genetic Diversity and Clonal Expansion of Pathogenic Leptospira in Brazil: A Multi-Host and Multi-Regional Panorama [PDF]
MicroorganismsLeptospirosis is a globally distributed zoonosis of major public health and veterinary relevance, caused by pathogenic species of the genus Leptospira.
Maria Isabel Nogueira Di Azevedo +1 more
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Molecular Characterization of ‘Candidatus Phytoplasma prunorum’ in the Czech Republic and Susceptibility of Apricot Rootstocks to the Two Most Abundant Haplotypes [PDF]
Microorganisms‘Candidatus Phytoplasma prunorum’ is one of the most destructive pathogens of Prunus species, where susceptible species render unproductive several years after infection.
Tomáš Kiss +3 more
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International Journal of Plant Biology, 2022 Grapevine “bois noir”, related to the presence of ‘Candidatus Phytoplasma solani’ (‘Ca. P. solani’), represents a serious threat in several vine-growing areas worldwide.
Roberto Pierro +8 more
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A unified evolutionary origin for the ubiquitous protein transporters SecY and YidC
BMC Biology, 2021 Background Protein transporters translocate hydrophilic segments of polypeptide across hydrophobic cell membranes. Two protein transporters are ubiquitous and date back to the last universal common ancestor: SecY and YidC.
Aaron J. O. Lewis, Ramanujan S. Hegde
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SecY-SecA fusion protein retains the ability to mediate protein transport. [PDF]
PLoS ONE, 2017 In bacteria, the membrane protein complex SecY/E/G and SecA ATPase are essential for protein translocation. About 30% of newly synthesized proteins in the cytosol are targeted to and translocated across the cytoplasmic membrane by the Sec factors ...
Yasunori Sugano +4 more
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