Results 121 to 130 of about 3,879 (192)
Dynamic Organization of SecA and SecY Secretion Complexes in the B. subtilis Membrane.
PLoS ONE, 2016 In prokaryotes, about one third of cellular proteins are translocated across the plasma membrane or inserted into it by concerted action of the cytoplasmic ATPase SecA and the universally conserved SecYEG heterotrimeric polypeptide-translocating pore ...
Alex Dajkovic +3 more
doaj +1 more source
Molecular Mechanism of Co-translational Protein Targeting by the Signal Recognition Particle [PDF]
, 2011 The signal recognition particle (SRP) is a key component of the cellular machinery that couples the ongoing synthesis of proteins to their proper localization, and has often served as a paradigm for understanding the molecular basis of protein ...
Saraogi, Ishu, Shan, Shu-ou
core +1 more source
Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate Co-translational protein targeting [PDF]
, 2017 The signal recognition particle (SRP) delivers ~30% of the proteome to the eukaryotic endoplasmic reticulum, or the bacterial plasma membrane. The precise mechanism by which the bacterial SRP receptor, FtsY, interacts with and is regulated at the target ...
Fu, Yu-Hsien Hwang +5 more
core +1 more source
IUCrJ, 2018 Determining macromolecular structures from X-ray data with resolution worse than 3 Å remains a challenge. Even if a related starting model is available, its incompleteness or its bias together with a low observation-to-parameter ratio can render the ...
Pavol Skubák +12 more
doaj +1 more source
Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle.
PLoS Biology, 2020 Small membrane proteins represent a largely unexplored yet abundant class of proteins in pro- and eukaryotes. They essentially consist of a single transmembrane domain and are associated with stress response mechanisms in bacteria. How these proteins are
Ruth Steinberg +12 more
doaj +1 more source
Structure of the Sec61 channel opened by a signal sequence [PDF]
, 2016 Secreted and integral membrane proteins compose up to one-third of the biological proteome. These proteins contain hydrophobic signals that direct their translocation across or insertion into the lipid bilayer by the Sec61 protein–conducting channel. The
Hegde, Ramanujan S. +1 more
core +2 more sources
The role of bacterial secretion systems in the virulence of Gram-negative airway pathogens associated with cystic fibrosis [PDF]
, 2016 Cystic fibrosis (CF) is the most common lethal inherited disorder in Caucasians. It is caused by mutation of the CF transmembrane conductance regulator (CFTR) gene.
Depluverez, Sofie +2 more
core +2 more sources
Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202 [PDF]
, 2018 CYP17A1 is a key steroidogenic enzyme known to conduct several distinct chemical transformations on multiple substrates. In its hydroxylase activity, this enzyme adds a hydroxyl group at the 17α position of both pregnenolone and progesterone at ...
Bangcharoenpaurpong O. +8 more
core +2 more sources
, 2012 Bacteriën bezitten één of meerdere membraanlaagjes die het binnenste van de cel scheiden van de buitenwereld. Vaak moeten eiwitten, die in de cel geproduceerd worden, door het binnenste membraan van de cel getransporteerd worden om hun functie buiten de cel te kunnen uit te oefenen. Dit proces vindt paats middels een gespecialiseerd transportmechanisme,
openaire +1 more source
PLoS ONE, 2018 The SRP-Sec61 targeting/translocation pathway of eukaryotic cells targets nascent protein chains to the membrane of the endoplasmic reticulum. Using this machinery, secretory proteins are translocated across this membrane whereas membrane proteins are ...
Wolfgang Klein +11 more
doaj +1 more source