SecA mediates cotranslational targeting and translocation of an inner membrane protein [PDF]
, 2017 Protein targeting to the bacterial plasma membrane was generally thought to occur via two major pathways: cotranslational targeting by signal recognition particle (SRP) and posttranslational targeting by SecA and SecB.
Shan, Shu-ou, Wang, Shuai, Yang, Chien-I
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, 2012 We study the shapes of pored membranes within the framework of the Helfrich theory under the constraints of fixed area and pore size. We show that the mean curvature term leads to a budding- like structure, while the Gaussian curvature term tends to ...
de la Cruz, Monica Olvera +3 more
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Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY [PDF]
, 2005 During their biosynthesis, many proteins pass through the membrane via a hydrophilic channel formed by the heterotrimeric Sec61/SecY complex. Whether this channel forms at the interface of multiple copies of Sec61/SecY or is intrinsic to a monomeric ...
Cannon, Kurt S. +4 more
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The SecM arrest peptide traps a pre-peptide bond formation state of the ribosome
Nature CommunicationsNascent polypeptide chains can induce translational stalling to regulate gene expression. This is exemplified by the E. coli secretion monitor (SecM) arrest peptide that induces translational stalling to regulate expression of the downstream encoded SecA,
Felix Gersteuer +8 more
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An Investigation of the Function of the Periplasmic Domain of BamA, an Essential Protein in Gram-Negative Bacteria [PDF]
, 2013 Gram-negative bacteria make up the majority of dangerous health-care associated infections (HAIs), and are becoming increasingly resistant to standard antibiotics.
Castagneri, Danielle Andrea
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How SecB maintains clients in a translocation competent state
Communications BiologyBacterial secretory proteins must remain soluble and non-folded until they reach the SecYEG translocase. Preprotein intrinsic features and chaperones can delay protein folding.
Guillaume Roussel +4 more
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Similarly slow diffusion of BAM and SecYEG complexes in live E. coli cells observed with 3D spt-PALM. [PDF]
Biophys J, 2023 Lee Upton S +3 more
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Dynamic Structure of the Translocon SecYEG in Membrane [PDF]
Journal of Biological Chemistry, 2013 Raghavendar Reddy Sanganna Gari +4 more
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YidC from <i>Escherichia coli</i> Forms an Ion-Conducting Pore upon Activation by Ribosomes. [PDF]
Biomolecules, 2023 Knyazev DG +9 more
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Coping with stress: How bacteria fine-tune protein synthesis and protein transport. [PDF]
J Biol Chem, 2023 Njenga R, Boele J, Öztürk Y, Koch HG.
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