Results 41 to 50 of about 3,879 (192)
Inter-membrane association of the Sec and BAM translocons for bacterial outer-membrane biogenesis
eLife, 2020 The outer-membrane of Gram-negative bacteria is critical for surface adhesion, pathogenicity, antibiotic resistance and survival. The major constituent – hydrophobic β-barrel Outer-Membrane Proteins (OMPs) – are first secreted across the inner-membrane ...
Sara Alvira +11 more
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Phospholipids induce conformational changes of SecA to form membrane-specific domains: AFM structures and implication on protein-conducting channels. [PDF]
PLoS ONE, 2013 SecA, an essential component of the Sec machinery, exists in a soluble and a membrane form in Escherichia coli. Previous studies have shown that the soluble SecA transforms into pore structures when it interacts with liposomes, and integrates into ...
Zhipeng You +7 more
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Activated GTPase movement on an RNA scaffold drives co-translational protein targeting [PDF]
, 2012 Approximately one-third of the proteome is initially destined for the eukaryotic endoplasmic reticulum or the bacterial plasma membrane. The proper localization of these proteins is mediated by a universally conserved protein-targeting machinery, the ...
Akopian, David +4 more
core +1 more source
eLife, 2022 Transport of proteins across and into membranes is a fundamental biological process with the vast majority being conducted by the ubiquitous Sec machinery.
William J Allen +6 more
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Translocation of proteins through the Sec61 and SecYEG channels [PDF]
Current Opinion in Cell Biology, 2009 The Sec61 and SecYEG translocation channels mediate the selective transport of proteins across the endoplasmic reticulum and bacterial inner membrane, respectively. These channels are also responsible for the integration of membrane proteins. To accomplish these two critical events in protein expression, the transport channels undergo conformational ...
Elisabet C, Mandon +2 more
openaire +2 more sources
The molecular mechanism of cotranslational membrane protein recognition and targeting by SecA [PDF]
, 2019 Cotranslational protein targeting is a conserved process for membrane protein biogenesis. In Escherichia coli, the essential ATPase SecA was found to cotranslationally target a subset of nascent membrane proteins to the SecYEG translocase at the plasma ...
Ban, Nenad +5 more
core +1 more source
Protein translocation:what’s the problem? [PDF]
, 2016 We came together in Leeds to commemorate and celebrate the life and achievements of Prof. Stephen Baldwin. For many years we, together with Sheena Radford and Roman Tuma (colleagues also of the University of Leeds), have worked together on the problem of
Allen, William J +2 more
core +2 more sources
Glycolipozyme membrane protein integrase (MPIase): recent data
Biomolecular Concepts, 2014 A novel factor for membrane protein integration, from the cytoplasmic membrane of Escherichia coli, named MPIase (membrane protein integrase), has recently been identified and characterized.
Nishiyama Ken-ichi, Shimamoto Keiko
doaj +1 more source
Cell Reports, 2017 Summary: Protein secretion mediated by SecYEG translocon and SecA ATPase is enhanced by membrane-embedded SecDF by using proton motive force. A previous structural study of SecDF indicated that it comprises 12 transmembrane helices that can conduct ...
Arata Furukawa +10 more
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Dimeric SecA couples the preprotein translocation in an asymmetric manner. [PDF]
PLoS ONE, 2011 The Sec translocase mediates the post-translational translocation of a number of preproteins through the inner membrane in bacteria. In the initiatory translocation step, SecB targets the preprotein to the translocase by specific interaction with its ...
Ying Tang +4 more
doaj +1 more source