Results 121 to 130 of about 74,821 (300)

Intranasal delivery of E-selectin induces E-selectin specific regulatory cells.

, 2013
After 7 weeks on a high-fat diet, splenocytes were collected and cultured in X-vivo 15 alone or with 20 µg/ml E-selectin or 20 µg/ml OVA. Supernatant was collected at 72 h.
Xinhui Li (349485), Mark Bryant (349488), Jacqueline A. Quandt (349492), Abdel G. Elkahloun (208396), John M. Hallenbeck (125851), Ranil De Silva (349491), Marcelo Amar (349490), Kory R. Johnson (125846), Alan T. Remaley (77852)   +8 more
core   +1 more source

Neutrophil extracellular traps induced by activated platelets as a cause of neutrophil–platelet aggregation in β‐thalassaemia/haemoglobin E patients

British Journal of Haematology, EarlyView.
Abnormal neutrophils and platelets in splenectomised β‐thalassaemia/haemoglobin E (HbE) disease contribute to neutrophil–platelet aggregation, leading to a high risk of thrombus formation. Activated platelets induce neutrophils to generate neutrophil extracellular trap (NETs) via the P‐selectin–P‐selectin glycoprotein ligand‐1 (PSGL1) pathway, which ...
Rattanawan Thubthed, Rattanaporn Praneetponkang, Potchaman Sittipaisankul, Chayada Thiengtavor, Suwathida Chumpuchanaphai, Kittiphong Paiboonsukwong, Suthat Fucharoen, Kovit Pattanapanyasat, Jim Vadolas, Duncan R. Smith, Saovaros Svasti, Pornthip Chaichompoo   +11 more
wiley   +1 more source

Selectins. [PDF]

Journal of Clinical Investigation, 1993
M P, Bevilacqua, R M, Nelson
openaire   +2 more sources

sP-selectin, sE-selectin and cytokine/chemokine plasma levels in ApoE^−/− HFD mice receiving daily injections of recombinant sP-selectin or sE-selectin.

, 2014
A) Plasma levels of sP-selectin after 8 or 16 weeks of daily s.c injections (22.5 µg/kg/day) of vehicle control (saline matched volume; white bar), sP-selectin (black bar) or sE-selectin (checkered bar).
Emma Harris (285302), Jaye P. F. Chin-Dusting (315257), Natalie G. Lumsden (566450), Lu Fang (166449), Jennifer C. Irvine (299697), Alex Bobik (335995), Karen L. Andrews (315251), Andrea Aprico (566451), Kevin J. Woollard (566449), Ann-maree Jefferis (566452), Peter Kanellakis (335991)   +10 more
core   +1 more source

Thrombocytosis and the generation of platelet‐derived microparticles in the pathophysiology of sickle cell disease

British Journal of Haematology, EarlyView.
Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê, Anna Dillon, Owen P. Smith, Corrina McMahon   +3 more
wiley   +1 more source

P-selectin glycoprotein ligand-1 decameric repeats regulate selectin-dependent rolling under flow conditions.

, 2008
P-selectin glycoprotein ligand-1 (PSGL-1) interacts with selectins to support leukocyte rolling along vascular wall. L- and P-selectin bind to N-terminal tyrosine sulfate residues and to core-2 O-glycans attached to Thr-57, whereas tyrosine sulfation is ...
Joffraud, M., Schapira, M., Xie, X., Tauxe, C., Spertini, O., Martinez, M.   +5 more
core   +1 more source

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad   +17 more
wiley   +1 more source

Enhancement of L-Selectin, but Not P-Selectin, Bond Formation Frequency by Convective Flow

, 2008
L-selectin-mediated leukocyte rolling has been proposed to require a high rate of bond formation compared to that of P-selectin to compensate for its much higher off-rate.
Lawrence, Michael B., Christopher D. Paschall, Paschall, Christopher D., Guilford, William H., Michael B. Lawrence, William H. Guilford   +5 more
core   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Soluble P-selectin and L-selectin levels in serum of colorectal cancer patients and its clinical significance

Zhongguo aizheng zazhi, 2014
Background and purpose: Colorectal cancer is a kind of common digestive malignancies, which seriously threaten the human health. Although modern diagnostic and treatment technology has developed rapidly, the incidence and mortality of colorectal cancer ...
张梁, 罗桂飞, 元辉雄, 韦贵将
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