Results 101 to 110 of about 74,821 (300)

Pulmonary exposure to carbon nanotubes promotes murine arterial thrombogenesis via platelet P-selectin

, 2007
Carbon nanotubes, having a diameter as small as a few nanometers, yet with robust mechanical properties, can be functionalized with chemical and biological agents and be used for the delivery of target DNA molecules or peptides into specific tissues ...
P. Vandervoort (7579829), M.F. Hoylaerts (7579835), P.H.M. Hoet (7579832), B. Nemery (7579826), A. Nemmar (7579823), David Dinsdale (282533)   +5 more
core  

Surface-Bound Selectin-Ligand Binding Is Regulated By Carrier Diffusion

, 2009
Two-dimensional (2D) kinetics of receptor-ligand interactions governs cell adhesion in many biological processes. While the dissociation kinetics of receptor-ligand bond is extensively investigated, the association kinetics has much less been quantified.
孙淦云, 龙勉, 霍波, Long M, 章燕   +4 more
core   +1 more source

Clinical Significance of PCSK9 and Soluble P-selectin in Predicting Major Adverse Cardiovascular Events After Primary Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome

Cardiovascular Innovations and Applications
Objective: This study aimed at investigating the association of proprotein convertase subtilisin/kexin type 9 (PCSK9) with soluble P-selectin (sP-selectin), and their values in predicting major adverse cardiovascular events (MACE) at 1-year follow-up in
Yao Yao, Qining Qiu, Xiaoye Li, Zi Wang, Shikun Xu, Qianzhou Lv   +5 more
doaj   +1 more source

L-Selectin-deficient SJL and C57BL/6 mice are not resistant to experimental autoimmune encephalomyelitis

, 2008
L-selectin has been suggested to play a role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis.
Axinia Döring, Uboldi, Chiara, Estess, Pila, Siegelman, Mark, Engelhardt, Britta, Pila Estess, Mark Siegelman, Alt, Carsten, Britta Engelhardt, Chiara Uboldi, Döring, Axinia, Carsten Alt   +11 more
core   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Assessment of the E-Selectin rs5361 (561A>C) Polymorphism and Soluble Protein Concentration in Acute Coronary Syndrome: Association with Circulating Levels

Mediators of Inflammation, 2014
Introduction. The acute coronary syndrome (ACS) is a complex disease where genetic and environmental factors are involved. E-selectin gene is a candidate for ACS progression due to its contribution in the inflammatory process and endothelial function ...
Elena Sandoval-Pinto, Jorge Ramon Padilla-Gutiérrez, Emmanuel Valdes-Alvarado, Ilian Janet García-González, Angelica Valdez-Haro, Jose Francisco Muñoz-Valle, Hector Enrique Flores-Salinas, Fernando Rivas, Yeminia Valle   +8 more
doaj   +1 more source

Identification of thioaptamer ligand against E-selectin: potential application for inflamed vasculature targeting.

PLoS ONE, 2010
Active targeting of a drug carrier to a specific target site is crucial to provide a safe and efficient delivery of therapeutics and imaging contrast agents.
Aman P Mann, Anoma Somasunderam, René Nieves-Alicea, Xin Li, Austin Hu, Anil K Sood, Mauro Ferrari, David G Gorenstein, Takemi Tanaka   +8 more
doaj   +1 more source

P-selectin glycoprotein ligand-1 contributes to wound healing predominantly as a p-selectin ligand and partly as an e-selectin ligand. [PDF]

, 2009
Cell adhesion molecules are critical to wound healing through leukocyte recruitment. Although P-selectin glycoprotein ligand-1 (PSGL-1) regulates leukocyte rolling by binding P-selectin, but also binding E- and L-selectins with lower affinity, little is ...
Ayumi Yoshizaki, Iwata, Yohei, Kazuhiro Komura, Manabu Fujimoto, Hasegawa, Minoru, Sato, Shinichi, Toshihide Hara, Koichi Yanaba, Fujimoto, Manabu, Tomita, Hajime, Motoi Takenaka, Komura, Kazuhiro, Yanaba, Koichi, Minoru Hasegawa, Muroi, Eiji, Hara, Toshihide, Bae, Sangjae, Takenaka, Motoi, Fumihide Ogawa, Shimizu, Kazuhiro, Ogawa, Fumihide, Yoshizaki, Ayumi, Eiji Muroi, Kazuhiro Shimizu, Shinichi Sato, Yohei Iwata, Hajime Tomita, Sangjae Bae   +27 more
core   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Perbandingan Kadar Soluble Platelet-Selectin pada Berbagai Stadium Karsinoma Nasofaring Dan Korelasinya Dengan Hitung Trombosit

Jurnal Penyakit Dalam Indonesia, 2015
Pendahuluan. Karsinoma nasofaring (KNF) merupakan jenis keganasan yang unik dengan distribusi geografis dan etnis tertentu. Daerah Cina Selatan dan Asia Tenggara memiliki insidens kejadian yang tinggi.
Adi Surya Komala, Asrul Harsal, Andhika Rachman, Cleopas Martin Rumende   +3 more
doaj   +1 more source