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The selectins: Insights into selectin-induced intracellular signaling in leukocytes
Immunologic Research, 1995Characteristic features of the inflammatory and immune responses involve the recruitment of leukocytes to sites of tissue injury and the recirculation of lymphocytes through hematopoietic and lymphoid tissues. Recent studies indicate that the regulated cell surface expression of a family of protein adhesion molecules known as selectins and their ...
E, Crockett-Torabi, J C, Fantone
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Blood, 2009
In this issue of Blood , Yang and colleagues provide new insights into how plasma fibrinogen, fibrinogen uptake, and integrin signaling regulate P-selectin in circulating platelets.[1][1] Membrane P-selectin expression is considered one of the most reliable markers of murine and human ...
Hansjörg, Schwertz +2 more
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In this issue of Blood , Yang and colleagues provide new insights into how plasma fibrinogen, fibrinogen uptake, and integrin signaling regulate P-selectin in circulating platelets.[1][1] Membrane P-selectin expression is considered one of the most reliable markers of murine and human ...
Hansjörg, Schwertz +2 more
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Zooming in on selectins in cancer
Science Translational Medicine, 2016Selectins are involved in leukocyte and cancer cell trafficking, which can be targeted with drugs and nanoparticles (Shamay et al. , this issue).
Ranit, Kedmi, Dan, Peer
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Ligand-specificity of the selectins
Journal of Cellular Biochemistry, 1996The selectins are carbohydrate-binding cell adhesion molecules acting in the vascular system. They mediate the docking of leukocytes to the blood vessel wall and the rolling of these cells along the endothelial cell surface. These adhesion phenomena initiate the entry of leukocytes into sites of inflammation as well as the migration of recirculating ...
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Selectin synthesis and inflammation
Trends in Biochemical Sciences, 1996The selectins are a family of three cell-surface-presented glycoprotein receptors. They play a key role in the initial adhesive interaction between leukocytes and endothelial cells at sites of inflammation. The presence of selectins on the cell surface is tightly regulated and inappropriate appearance is associated with a number of inflammatory disease
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Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors.
Hematology/oncology clinics of North America, 2014The pathophysiology of vasoocclusion is thought to involve a wide variety of adhesive interactions involving erythrocytes, leukocytes, and the endothelium. Selectins are expressed by leukocytes, platelets, and the endothelium, among other tissues. They contribute to a wide variety of physiologically important cell-cell interactions, including adhesion ...
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[Selectin family (E-selectin, P-selectin, L-selectin)].
Nihon rinsho. Japanese journal of clinical medicine, 2011Yoko, Ishihara +2 more
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