Results 221 to 230 of about 24,758 (269)
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Fibrinogen selects selectins

Blood, 2009
In this issue of Blood , Yang and colleagues provide new insights into how plasma fibrinogen, fibrinogen uptake, and integrin signaling regulate P-selectin in circulating platelets.[1][1] Membrane P-selectin expression is considered one of the most reliable markers of murine and human ...
Hansjörg, Schwertz   +2 more
openaire   +2 more sources

Serum L-selectin and P-selectin levels in lymphomas

Haematologia, 2000
The migration of normal and malignant lymphoid cells is governed by specific adhesion molecules. Selectins comprise a family of adhesion receptors expressed by leukocytes, platelets and endothelial cells. In this study, the serum levels of soluble L-selectin and P-selectin were measured in patients with non-Hodgkin's lymphoma and Hodgkin's disease and ...
I C, Haznedaroglu   +6 more
openaire   +2 more sources

The selectin–selectin ligand axis in tumor progression

Cancer and Metastasis Reviews, 2008
This review will document that the selectin-selectin ligand axis is actively involved in tumor progression and drives this process. The involvement of selectins and their ligands in tumor progression takes place at three levels which will be reviewed: Interaction of tumor cells with platelets and leukocytes resulting in the formation of circulating ...
openaire   +2 more sources

Functions of Selectins

2001
The selectins are cell surface lectins that have evolved to mediate the adhesion of white blood cells to endothelial cells and platelets under flow. They recognize fucosylated, sialylated and in some cases sulfated ligands expressed on scaffold glycoproteins serving as functional counter-receptors.
openaire   +2 more sources

Selectin‐Inhibitoren

Nachrichten aus Chemie, Technik und Laboratorium, 1998
AbstractSynthese im Blickpunkt will zur Beschäftigung mit neuen synthetischen Verfahren oder besonders eleganten und wichtigen Synthesen aus der chemischen Literatur anregen ‐ ohne Anspruch auf Vollständigkeit. Die Rubrik erscheint von April bis Dezember alle zwei Monate und wird 1998 von Dr. Karola Rück‐Braun, Universität Mainz, betreut.
openaire   +1 more source

The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans

Nature Reviews Drug Discovery, 2021
Benjamin A H Smith, Carolyn R Bertozzi
exaly  

Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors.

Hematology/oncology clinics of North America, 2014
The pathophysiology of vasoocclusion is thought to involve a wide variety of adhesive interactions involving erythrocytes, leukocytes, and the endothelium. Selectins are expressed by leukocytes, platelets, and the endothelium, among other tissues. They contribute to a wide variety of physiologically important cell-cell interactions, including adhesion ...
openaire   +1 more source

L-selectin

Experimental and Toxicologic Pathology, 2005
The leucocyte expressed surface-bound L-selectin belongs to the selectin family of adhesion molecules. It exhibits adhesive as well as signalling functions. Mainly, it is of importance in lymphocyte homing and in the extravasation of leucocytes into the surrounding tissue during inflammation.
Barkhausen, T   +2 more
openaire   +1 more source

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