Results 211 to 220 of about 14,056 (288)

Multifaceted Role of Extracellular Vesicles: Intercellular Messengers to Therapeutic Applications: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra, Satya Kumar Lalam, Shefali Srivastava, Madan Kumar Arumugam, Lokesh Kumar Boopathy, Simran Takkar, Zhiqiu Xia, Sabarinath Peruvemba Subramanian   +7 more
wiley   +1 more source

Sialyl Lewis^x Glycomimetics as E- and P-Selectin Antagonists Targeting Hyperinflammation. [PDF]

ACS Med Chem Lett
Joyal M, Simard RD, Maharsy W, Prévost M, Nemer M, Guindon Y.   +5 more
europepmc   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Drug Management of Inflammatory Bowel Disease (IBD): A Narrative Review. [PDF]

Cureus
Singh P, Saini P, Kalyankar PP, Kailey KR, Chauhan R, Pannu AK, Singh N, Garg K.   +7 more
europepmc   +1 more source

Surface N‐Glycosylation Dictates MSC‐EV Uptake and CCR2‐Driven Monocyte Recruitment to Inflamed Endothelium Under Shear Flow

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Mesenchymal stromal cell‐derived extracellular vesicles (MSC‐EV) hold promising potential for immunomodulation and tissue regeneration, especially for treating ischemia‐reperfusion injury (IRI). However, their therapeutic use is hindered by challenges in tissue targeting and incomplete understanding of their functional mechanisms.
Marta Clos‐Sansalvador, Marta Monguió‐Tortajada, Sergio G. Garcia, Manuel Pérez‐Martínez, Marta Sanroque‐Muñoz, Miriam Font‐Morón, Diego Megías, Isabel Peset, Marcella Franquesa, Marta Hergueta‐Redondo, Hector Peinado, Francesc E. Borràs   +11 more
wiley   +1 more source

Cytotoxic Effect of a β1,4-Galactosyltransferase Inhibitor in Hepatic Carcinoma Cells. [PDF]

Cells
Dai Z, Sun M, Chen L, Fu X, Yan W, Gao Y, Brockhausen I.   +6 more
europepmc   +1 more source

The Model of Neutrophil Chemotaxis Participated by the Vascular Endothelial Glycocalyx. [PDF]

Int J Gen Med
Li P, Si Z, Shao Y, Wu W.
europepmc   +1 more source

Prognostic Impact and Clinicopathological Significance of TIM‐3 and LAG‐3 Expressions in Laryngeal Squamous Cell Carcinoma

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.
ABSTRACT Introduction Research on immune checkpoint molecules is increasing, reflecting their critical role in cancer pathogenesis. While PD‐1, PD‐L1, and CTLA‐4 have been widely studied in head and neck cancers, outcomes remain unsatisfactory, highlighting the need for novel prognostic markers and therapeutic targets.
Fırat Tevetoğlu, Nil Çomunoğlu, Haydar Murat Yener   +2 more
wiley   +1 more source

Distinct Neurodegenerative Pathways in Two NBIA Subtypes: Inflammatory Activation in <i>C19orf12</i> but Not in <i>PANK2</i> Mutation Carriers. [PDF]

Cells
Skowrońska M, Cudna A, Pakuła B, Lebiedzińska-Arciszewska M, Janikiewicz J, Dobosz AM, Jakubek-Olszewska P, Wydrych A, Cwyl M, Dobrzyń A, Więckowski MR, Kurkowska-Jastrzębska I.   +11 more
europepmc   +1 more source

Gastric Cancer: Pathobiology and Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu, Miao Zhang, Yan Meng, Chunxiao Zhu, Weihong Zhang, Hui Zhang, Zhifa Cao, Meihang Du, Zhangting Zhao, Junping Bai, Yi Han, Yang Tang, Wei Kang, Ka Fai To, Shi Jiao, Liwei An, Zhaocai Zhou   +16 more
wiley   +1 more source