Results 201 to 210 of about 12,701 (240)
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The selectin–selectin ligand axis in tumor progression
Cancer and Metastasis Reviews, 2008This review will document that the selectin-selectin ligand axis is actively involved in tumor progression and drives this process. The involvement of selectins and their ligands in tumor progression takes place at three levels which will be reviewed: Interaction of tumor cells with platelets and leukocytes resulting in the formation of circulating ...
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E‐selectin and L‐selectin polymorphisms in patients with periodontitis
Journal of Periodontal Research, 2009Background amd Objective: Periodontitis is a multifactorial disease in which environmental and genetic determinant factors contribute to individual subject’s susceptibility. A DNA polymorphism in the regulating region of adhesion molecule genes is suggested to modulate the molecule’s physiological effects.
B, Houshmand +4 more
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2001
The selectins are cell surface lectins that have evolved to mediate the adhesion of white blood cells to endothelial cells and platelets under flow. They recognize fucosylated, sialylated and in some cases sulfated ligands expressed on scaffold glycoproteins serving as functional counter-receptors.
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The selectins are cell surface lectins that have evolved to mediate the adhesion of white blood cells to endothelial cells and platelets under flow. They recognize fucosylated, sialylated and in some cases sulfated ligands expressed on scaffold glycoproteins serving as functional counter-receptors.
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Serum L-selectin and P-selectin levels in lymphomas
Haematologia, 2000The migration of normal and malignant lymphoid cells is governed by specific adhesion molecules. Selectins comprise a family of adhesion receptors expressed by leukocytes, platelets and endothelial cells. In this study, the serum levels of soluble L-selectin and P-selectin were measured in patients with non-Hodgkin's lymphoma and Hodgkin's disease and ...
I C, Haznedaroglu +6 more
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The Selectins and Their Ligands
1993Among the four major groups of cell adhesion molecules (CAMs) the selectins represent the smallest and most recently identified gene family (Lasky 1992; Vestweber 1992). In contrast to the three large families of the integrins, the immunoglobulin super gene family and the cadherins, the selectins consist of only three members: L-, E-, and P-selectin ...
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The selectins: Insights into selectin-induced intracellular signaling in leukocytes
Immunologic Research, 1995Characteristic features of the inflammatory and immune responses involve the recruitment of leukocytes to sites of tissue injury and the recirculation of lymphocytes through hematopoietic and lymphoid tissues. Recent studies indicate that the regulated cell surface expression of a family of protein adhesion molecules known as selectins and their ...
E, Crockett-Torabi, J C, Fantone
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Zooming in on selectins in cancer
Science Translational Medicine, 2016Selectins are involved in leukocyte and cancer cell trafficking, which can be targeted with drugs and nanoparticles (Shamay et al. , this issue).
Ranit, Kedmi, Dan, Peer
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Selectin synthesis and inflammation
Trends in Biochemical Sciences, 1996The selectins are a family of three cell-surface-presented glycoprotein receptors. They play a key role in the initial adhesive interaction between leukocytes and endothelial cells at sites of inflammation. The presence of selectins on the cell surface is tightly regulated and inappropriate appearance is associated with a number of inflammatory disease
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Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors.
Hematology/oncology clinics of North America, 2014The pathophysiology of vasoocclusion is thought to involve a wide variety of adhesive interactions involving erythrocytes, leukocytes, and the endothelium. Selectins are expressed by leukocytes, platelets, and the endothelium, among other tissues. They contribute to a wide variety of physiologically important cell-cell interactions, including adhesion ...
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