Results 71 to 80 of about 3,585,940 (324)

Detecting signatures of balancing selection to identify targets of anti-parasite immunity.

, 2010
Parasite antigen genes might evolve under frequency-dependent immune selection. The distinctive patterns of polymorphism that result can be detected using population genetic methods that test for signatures of balancing selection, allowing genes encoding
Conway, David J, Weedall, Gareth D
core   +1 more source

An evaluation of DNA-damage response and cell-cycle pathways for breast cancer classification [PDF]

, 2014
Accurate subtyping or classification of breast cancer is important for ensuring proper treatment of patients and also for understanding the molecular mechanisms driving this disease.
Fard, Atefeh Taherian, Ragan, Mark A., Srihari, Sriganesh   +2 more
core   +5 more sources

Whole-Genome Sequencing Reveals the Genomic Characteristics and Selection Signatures of Hainan Black Goat

Genes, 2022
Goats have become one of the most adaptive and important livestock species distributed in developing countries in recent years. The Hainan Black goat is a native goat breed of the Hainan region that is generally well-liked by the local population and is ...
Qiaoling Chen, Y. Chai, Wencan Zhang, Yiwen Cheng, Zhenxing Zhang, Qi An, Si Chen, Churiga Man, Li Du, Wenguang Zhang, Fengyang Wang   +10 more
semanticscholar   +1 more source

Comparing Patterns of Natural Selection across Species Using Selective Signatures

PLoS Genetics, 2005
Comparing gene expression profiles over many different conditions has led to insights that were not obvious from single experiments. In the same way, comparing patterns of natural selection across a set of ecologically distinct species may extend what can be learned from individual genome-wide surveys.
Shapiro, Jesse, Alm, Eric J.
openaire   +4 more sources

Genetic Diversity and Signatures of Selection in 15 Chinese Indigenous Dog Breeds Revealed by Genome-Wide SNPs

Frontiers in Genetics, 2019
There are dozens of recognized indigenous dog breeds in China. However, these breeds have not had extensive studies to describe their population structure, genomic linkage disequilibrium (LD) patterns, and selection signatures.
Qianyong Yang, Qianyong Yang, Hao Chen, Junhua Ye, Chenlong Liu, Rongxing Wei, Congying Chen, Lusheng Huang   +7 more
doaj   +1 more source

Identifying Signatures of Selection in Genetic Time Series

, 2013
Both genetic drift and natural selection cause the frequencies of alleles in a population to vary over time. Discriminating between these two evolutionary forces, based on a time series of samples from a population, remains an outstanding problem with ...
Feder, Alison, Kryazhimskiy, Sergey, Plotkin, Joshua B.   +2 more
core   +1 more source

Analysis of 206 whole‐genome resequencing reveals selection signatures associated with breed‐specific traits in Hu sheep

Evolutionary Applications
As an invaluable Chinese sheep germplasm resource, Hu sheep are renowned for their high fertility and beautiful wavy lambskins. Their distinctive characteristics have evolved over time through a combination of artificial and natural selection ...
F. Zhao, Rui Xie, L. Fang, R. Xiang, Zehu Yuan, Yang Liu, Lixian Wang   +6 more
semanticscholar   +1 more source

Signatures of Diversifying Selection in European Pig Breeds [PDF]

PLoS Genetics, 2013
Following domestication, livestock breeds have experienced intense selection pressures for the development of desirable traits. This has resulted in a large diversity of breeds that display variation in many phenotypic traits, such as coat colour, muscle composition, early maturity, growth rate, body size, reproduction, and behaviour.
Wilkinson, S., Lu, Z.H., Megens, H.J.W.C., Archibald, A.L., Haley, C., Jackson, I.J., Groenen, M.A.M., Crooijmans, R.P.M.A., Ogden, R., Wiener, P.   +9 more
openaire   +5 more sources

Signatures of selection with cultural interference

Proceedings of the National Academy of Sciences
Human evolution is intricately linked with culture, which permeates almost all facets of human life from health and reproduction, to the environments in which we live. Nevertheless, our understanding of the ways in which stably transmitted, evolutionarily relevant human cultural traits might interact with the human genome is incomplete, and methods to ...
Laurel Fogarty, Sarah P. Otto
openaire   +4 more sources

Robust selection of cancer survival signatures from high-throughput genomic data using two-fold subsampling.

PLoS ONE, 2014
Identifying relevant signatures for clinical patient outcome is a fundamental task in high-throughput studies. Signatures, composed of features such as mRNAs, miRNAs, SNPs or other molecular variables, are often non-overlapping, even though they have ...
Sangkyun Lee, Jörg Rahnenführer, Michel Lang, Katleen De Preter, Pieter Mestdagh, Jan Koster, Rogier Versteeg, Raymond L Stallings, Luigi Varesio, Shahab Asgharzadeh, Johannes H Schulte, Kathrin Fielitz, Melanie Schwermer, Katharina Morik, Alexander Schramm   +14 more
doaj   +1 more source