Results 71 to 80 of about 11,168 (173)

Sultams as Dual Inhibitors of Human Carbonic Anhydrase and Thioredoxin Reductase

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
A series of sultam‐based N‐acyl derivatives with potential applications as dual TrxR1 and CA inhibitors were synthesized and evaluated. TrxR1 screening identified several active compounds, with inhibitory potency influenced by the type and orientation of substituents.
Aleksandrs Pustenko, Raitis Bobrovs, Venkatesan Saravanan, Kathir Avan, Simone Carradori, Antons Sizovs, Andrea Angeli, Claudiu T. Supuran, Raivis Žalubovskis   +8 more
wiley   +1 more source

Thioredoxin Reductase as a Target for Antibacterial Gold Compounds in Burkholderia cenocepacia: Disclosing the Molecular Basis of Enzyme Inhibition

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
The molecular basis of thioredoxin reductase inhibition by antibacterial gold(I) compounds is disclosed. X‐ray crystallography and high‐resolution ESI‐MS reveal selective gold coordination to catalytically relevant cysteine residues of Bc‐TrxR, leading to stable protein–gold adducts and disruption of enzyme redox activity.
Stefano Zineddu, José Aleixo de Azevedo‐França, Martina Aguanno, Valentina Pecchioli, Giarita Ferraro, Virginia Cuomo, Antonello Merlino, Luigi Messori   +7 more
wiley   +1 more source

Furagin Derivatives—Nitrofuran‐Based Hydrazones as Potential Dual Inhibitors of Thioredoxin Reductase and Carbonic Anhydrases

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Nitrofuran‐based hydrazones derived from furagin are developed as dual inhibitors of thioredoxin reductase 1 and cancer‐associated carbonic anhydrases IX and XII. The series shows selective enzyme inhibition with reduced off‐target carbonic anhydrase (CA) I/II activity, while lead compound 7g exhibits potent TrxR1 inhibition and moderate anticancer ...
Aleksandrs Pustenko, Raitis Bobrovs, Katrīna Freimane, Antons Sizovs, Andrea Angeli, Claudiu T. Supuran, Raivis Žalubovskis   +6 more
wiley   +1 more source

The C-terminal selenenylsulfide of extracellular/non-reduced thioredoxin reductase endows this protein with selectivity to small-molecule electrophilic reagents under oxidative conditions

Frontiers in Molecular Biosciences
Mammalian cytosolic thioredoxin reductase (TrxR1) serves as an antioxidant protein by transferring electrons from NADPH to various substrates. The action of TrxR1 is achieved via reversible changes between NADPH-reduced and non-reduced forms, which ...
Huijun Qin, Chenchen Guo, Bozhen Chen, Hui Huang, Yaping Tian, Liangwei Zhong   +5 more
doaj   +1 more source

Foliar selenium biofortification of soybean: the potential for transformation of mineral selenium into organic forms

Frontiers in Plant Science
IntroductionSelenium (Se) deficiency, stemming from malnutrition in humans and animals, has the potential to disrupt many vital physiological processes, particularly those reliant on specific selenoproteins.
Tomáš Mrština, Lukáš Praus, Jiřina Száková, Lukáš Kaplan, Pavel Tlustoš   +4 more
doaj   +1 more source

Defining the methanogenic SECIS element in vivo by targeted mutagenesis

RNA Biology
In all domains of life, Archaea, Eukarya and Bacteria, the unusual amino acid selenocysteine (Sec) is co-translationally incorporated into proteins by recoding a UGA stop codon to a sense codon.
Nils Peiter, Anna Einert, Pauline Just, Frida Jannasch, Marija Najdovska, Michael Rother   +5 more
doaj   +1 more source

Cloning and Expression of Cellular Glutathione Peroxidase (GPX1) in Japanese Quail (Coturnix japonica)

The Journal of Poultry Science, 2009
Glutathione peroxidase 1 (cellular glutathione peroxidase, EC 1.11.1.9 (GPX1)) is an antioxidant enzyme that plays an important role in scavenging reactive oxygen species to protect cells from oxidative damage.
Sopon Wilaison, Makoto Mori
doaj   +1 more source

On-Resin Selenopeptide Catalysts: Synthesis and Applications of Enzyme-Mimetic Reactions and Cyclization of Unsaturated Carboxylic Acids

Molecules
Selenium reagents are useful for selenoenzyme-mimicking reactions, as well as for organic synthesis. However, the reaction waste containing selenium frequently smells unpleasant and exhibits serious toxicity.
Michio Iwaoka, Yua Maese, Kasumi Abe
doaj   +1 more source

Selenocysteine [PDF]

, 2020
openaire   +1 more source

Why Selenocysteine Is Unique?

Frontiers in Molecular Biosciences, 2020
Vitor Hugo Balasco Serrão, Jessica Fernandes Scortecci   +1 more
doaj   +1 more source