Selenoproteins in mammalian spermatogenesis:role of the nuclear GPx4 [PDF]
, 2011 The selenoprotein Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx/GPx4) is an enzyme unique among the various GPxs, because it is able to use protein thiols, beside glutathione, The GPx4 gene encodes for three isoforms having different ...
Maccari, Irene
core
Health Care Evolves From Reactive to Proactive. [PDF]
, 2019 Decoding health and disease pathways drives healthcare evolution. Historically, therapeutic paradigms have relied on interventions that mitigate symptoms of established diseases.
Terzic, Andre, Waldman, Scott A.
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Bioinformatic analysis of glutathione peroxidase family from theobroma cacao and gene expression during Moniliophthora perniciosa infection.[Poster-B185] [PDF]
, 2018 Glutathione peroxidases (GPXs) are enzymes which are part of the antioxidant system of the cell. Mammalian GPXs are known as selenoproteins because containing the selenocysteine (Sec) amino acid. In plants, these proteins are less known.
Andrade, Bruno Silva +4 more
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Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P [PDF]
, 2017 Selenoprotein biosynthesis relies on the co-translational insertion of selenocysteine in response to UGA codons. Aminoglycoside antibiotics interfere with ribosomal function and may cause codon misreading.
Everley, Robert A. +11 more
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Selenoproteins and selenoproteomes
, 2007 Recent progress in high-throughput sequencing and analysis allowed efficient identification of selenocysteine-containing proteins in sequence databases, including full sets of selenoproteins in organisms, designated selenoproteomes. Information is currently available on selenoproteomes from all major model organisms as well as humans, which have 25 ...
openaire +2 more sources
Selenoproteins and Thyroid Cancer
, 2011 Selenoproteins, in which Se exists in the form of selenocysteine, are essential for protection against oxidative damage and cancer. Genetic data has provided evidence that reduced levels of these proteins, induced by loss of heterozygosity or chromosomal alterations [1], result in cellular oxidative stress as well as derangement of signaling cascades ...
Duntas, L.H., Smyth, P.P.A.
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Needed for completion of the human genome: hypothesis driven experiments and biologically realistic mathematical models [PDF]
, 2004 With the sponsorship of ``Fundacio La Caixa'' we met in Barcelona, November 21st and 22nd, to analyze the reasons why, after the completion of the human genome sequence, the identification all protein coding genes and their variants remains a distant ...
Birney, Ewan +7 more
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Selenoprotein M is expressed during bone development [PDF]
, 2013 25 selenoproteins that contain selenium, incorporated as selenocysteine (Sec), have been identified to date. Selenoprotein M (SELM) is one of seven endoplasmic reticulum (ER)-resident, Sec-containing proteins that may be involved in posttranslational ...
Bösl, Michael +4 more
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Selenoproteins - biochemistry and clinical relevance [PDF]
, 2007 Böck, August +2 more
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Development of a New Method for the Absolute Quantification of Selenoproteins in Chicken Serum by Heteroatom-Tagged Proteomics. [PDF]
J Agric Food ChemCallejón-Leblic B +3 more
europepmc +1 more source