Results 51 to 60 of about 118,134 (219)

Design and analysis of a novel coupled converter with high‐voltage insulation protection in magnetic isolated way

IET Power Electronics, 2021
This paper presents a novel coupled converter with high‐voltage insulation protection in magnetic isolated way by taking the case of heater/ignitor/keeper supply for powering discharge cathode in the space ion electric propulsion (EP) thruster.
Ming Fu, Donglai Zhang, Di Zhang, Xiantao Zhang   +3 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Adaptive fuzzy control for non‐strict‐feedback stochastic uncertain non‐linear systems based on event‐triggered strategy

IET Control Theory & Applications, 2021
This paper investigates the issue of adaptive fuzzy control for a category of non‐strict‐feedback stochastic uncertain non‐linear systems. Based on event‐triggered mechanism, an adaptive fuzzy controller with a simple form is designed by combining ...
Yuxiao Lian, Jianwei Xia, Wei Sun, Zhen Wang, Huasheng Zhang   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Robust iterative learning control for uncertain continuous‐time system with input delay and random iteration‐varying uncertainties

IET Control Theory & Applications, 2021
This study deals with the problem of robust iterative learning control (ILC) for linear continuous‐time systems with input delay subject to uncertainties in input delay, plant dynamic, reference trajectory, initial conditions and disturbances.
Hamid Shokri‐Ghaleh, Soheil Ganjefar, Alireza Mohammad Shahri   +2 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A fuzzy adaptive admittance controller for force tracking in an uncertain contact environment

IET Control Theory & Applications, 2021
Traditional constant admittance controller (CAC) in uncertain contact environment is highly dependent on environmental location and stiffness, which are always difficult to obtain in most applications. To address this problem, a fuzzy adaptive admittance
Zhisen Li, Hailin Huang, Xiaogang Song, Wenfu Xu, Bing Li   +4 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Enhanced PI control and adaptive gain tuning schemes for distributed secondary control of an islanded microgrid

IET Renewable Power Generation, 2021
This paper develops an enhanced proportional‐integral distributed control scheme (EPI‐DCS) to regulate the frequency and voltage of a droop‐controlled microgrid and share the power mismatch, simultaneously.
Yuanshi Zhang, Amin Mohammadpour Shotorbani, Liwei Wang, Behnam Mohammadi‐Ivatloo   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source