Results 51 to 60 of about 177,662 (265)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Design and analysis of a novel coupled converter with high‐voltage insulation protection in magnetic isolated way

IET Power Electronics, 2021
This paper presents a novel coupled converter with high‐voltage insulation protection in magnetic isolated way by taking the case of heater/ignitor/keeper supply for powering discharge cathode in the space ion electric propulsion (EP) thruster.
Ming Fu, Donglai Zhang, Di Zhang, Xiantao Zhang   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Robust iterative learning control for uncertain continuous‐time system with input delay and random iteration‐varying uncertainties

IET Control Theory & Applications, 2021
This study deals with the problem of robust iterative learning control (ILC) for linear continuous‐time systems with input delay subject to uncertainties in input delay, plant dynamic, reference trajectory, initial conditions and disturbances.
Hamid Shokri‐Ghaleh, Soheil Ganjefar, Alireza Mohammad Shahri   +2 more
doaj   +1 more source

DYNAMICO: A Reference Model for Governing Control Objectives and Context Relevance in Self-Adaptive Software Systems

, 2010
Despite the valuable contributions on self-adaptation, most implemented approaches assume adaptation goals and monitoring infrastructures as non-mutable, thus constraining their applicability to systems whose context awareness is restricted to static ...
Casallas, Rubby, Müller, Hausi A., Villegas, Norha Milena, Duchien, Laurence, Tamura Morimitsu, Gabriel   +4 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Control of self-organizing nonlinear systems

, 2016
The book summarizes the state-of-the-art of research on control of self-organizing nonlinear systems with contributions from leading international experts in the field.
Klapp, Sabine, Hövel, Philipp, Schöll, Eckehard   +2 more
core   +2 more sources

A fuzzy adaptive admittance controller for force tracking in an uncertain contact environment

IET Control Theory & Applications, 2021
Traditional constant admittance controller (CAC) in uncertain contact environment is highly dependent on environmental location and stiffness, which are always difficult to obtain in most applications. To address this problem, a fuzzy adaptive admittance
Zhisen Li, Hailin Huang, Xiaogang Song, Wenfu Xu, Bing Li   +4 more
doaj   +1 more source

Software Engineering Meets Control Theory [PDF]

, 2015
International audienceThe software engineering community has proposed numerous approaches for making software self-adaptive. These approaches take inspiration from machine learning and control theory, constructing software that monitors and modifies its ...
Ilias Gerostathopoulos, Papadopoulos, Alessandro,, Krikava, Filip, Jamshidi, Pooyan, Hoffmann, H, Sharifloo, Amir M., Sharifloo, AM, Andreas Berndt Hempel, Evangelia Kalyvianaki, Vogel, T, Ray, Suprio, Maggio, M, Hempel, Andreas, Hempel, AB, Sasa Misailovic, Angelopoulos, Konstantinos, Cristian Klein, Hoffmann, Henry, Filip Krikava, D'Ippolito, Nicolas, Shevtsov, Stepan,, Henry Hoffmann, Papadopoulos, Alessandro Vittorio,, Thomas Vogel, Amir M. Sharifloo, Ujma, M, Maggio, Martina, Pooyan Jamshidi, Berndt Hempel, Andreas, Shevtsov, Stepan, Filieri, Antonio, Kalyvianaki, E, Misailovic, S, Nicolas D'Ippolito, Lund University., Sharifloo, Amir, Molzam, Hempel, Andreas Berndt, Klein, Cristian, Alessandro Vittorio Papadopoulos, Maggio, Martina,, Vogel, Thomas, Antonio Filieri, Martina Maggio, Sharifloo, Amir,, D Ippolito, N, Gerostathopoulos, I, Jamshidi, P, Misailovic, Sasa, Stepan Shevtsov, Kalyvianaki, Evangelia, Angelopoulos, K, Klein, C, Krikava, F, Suprio Ray, Ray, S, Ro Vittorio Papadopoulos, Papadopoulos, AV, Papadopoulos, Alessandro ,, Papadopoulos, Alessandro Vittorio, Amir M Sharifloo, Gerostathopoulos, Ilias, Konstantinos Angelopoulos, Filieri, A, Shevtsov, S, Mateusz Ujma, Papadopoulos, Alessandro, Vittorio, Ujma, Mateusz   +66 more
core   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source