Results 101 to 110 of about 3,937 (174)

Semaphorin7A promotes tumor growth and exerts a pro-angiogenic effect in macrophages of mammary tumor-bearing mice

Frontiers in Physiology, 2014
Semaphorins, a large family of molecules involved in the axonal guidance and development of the nervous system, have been recently shown to have both angiogenic and anti-angiogenic properties.
Ramon eGarcia-Areas, Stephania eLibreros, Samantha eAmat, Patricia eKeating, Roberto eCarrio, Philip eRobinson, Clifford R Blieden, Vijaya eIragavarapu-Charyulu   +7 more
doaj   +1 more source

Semaphorin-7A blocks α-SMA and periostin production in HLF.

, 2017
HLF derived from non-fibrotic lungs were treated with the indicated siRNAs for 24 h. HLF were subsequently starved in BSA for 24 h before either adding TGF-ß (1 ng/ml) or left in BSA for 20 h.
Elizabeth A. Kelly (429798), Stephane Esnault (24104), Mats W. Johansson (2584933), Elizabeth E. Torr (3663346), Nathan Sandbo (777206), Ksenija Bernau (3663349), Nizar N. Jarjour (103237)   +6 more
core   +1 more source

Impact of Semaphorin 7A expression on tumorigenicity and immunogenicity of malignant gliomas

, 2011
Die Prognose von Patienten mit malignen Gliomen ist infaust und bisher ist eine kurative Therapie nicht möglich. Maligne Gliome zeichnen sich durch ihr stark migratorisches Verhalten, die sehr frühe und diffuse Infiltration von benachbarten Hirnarealen ...
Tonder, Michaela
core  

Semaphorin-7A inhibits the expression of myofibroblast markers.

, 2017
Non-fibrotic HLF were treated with control-siRNA (C), sema7A-siRNA (S) or plexin C1-siRNA (P) for 24 h before starvation in BSA for 24 h. Then, the cells were either kept in BSA or activated with TGF-ß (1 ng/ml) for 20 h.
Elizabeth A. Kelly (429798), Stephane Esnault (24104), Mats W. Johansson (2584933), Elizabeth E. Torr (3663346), Nathan Sandbo (777206), Ksenija Bernau (3663349), Nizar N. Jarjour (103237)   +6 more
core   +1 more source

Matrix stiffness induced gallbladder fibroblasts activation and paracrine SEMA7A promotes gallbladder cancer cell epithelial-mesenchymal transition and cancer stem cell-like properties by modulating AKT/p300 signalling

Biology Direct
Background & aims Gallbladder cancer (GBC) is characterised by a desmoplastic microenvironment rich in collagen fibres and extracellular matrix, contributing to increased matrix stiffness.
Liankang Sun, Huanhuan Wang, Hanqi Li, Ruida Yang, Xuyuan Dong, Danfeng Dong, Yangwei Fan, Enxiao Li, Hao Wang, Yinying Wu, Yu Shi   +10 more
doaj   +1 more source

Associations of SEMA7A, SEMA4D, ADAMTS10, and ADAM8 with KRAS, NRAS, BRAF, PIK3CA, and AKT Gene Mutations, Microsatellite Instability Status, and Cytokine Expression in Colorectal Cancer Tissue

Current Issues in Molecular Biology
Semaphorins (SEMAs), ADAM, and ADAMTS family members are implicated in various cancer progression events within the tumor microenvironment across different cancers. In this study, we aimed to evaluate the expression of SEMA7A, SEMA4D, ADAM8, and ADAMTS10
Błażej Ochman, Piotr Limanówka, Sylwia Mielcarska, Agnieszka Kula, Miriam Dawidowicz, Wiktor Wagner, Dorota Hudy, Monika Szrot, Jerzy Zbigniew Piecuch, Jerzy Piecuch, Zenon Czuba, Elżbieta Świętochowska   +11 more
doaj   +1 more source

Expression of semaphorins-4D, -6D, -3C and -7A in hepatitis C virus infection [PDF]

, 2017
Virus hepatitisa C (HCV) je RNA virus iz porodice Flaviviridae, rod Hepacivirus, koji uzrokuje akutne i kronične bolesti jetre uključujući kronični hepatitis, cirozu te hepatocelularni karcinom.
Ljubić, Sven
core  

[Retracted] Anti‑Semaphorin‑7A single chain antibody demonstrates beneficial effects on pulmonary inflammation during acute lung injury. [PDF]

Exp Ther Med, 2023
Chen X, Wang H, Jia K, Wang H, Ren T.
europepmc   +1 more source

The Regulatory Effect of Semaphorin 7A on Proliferation and Migration in Human Umbilical Vein Endothelial Cells

, 2013
Semaphorin 7A (SEMA 7A), a factor originally identified as regulating axon growth, has recently been implicated as a pro-angiogenic factor. The molecular mechanisms for this ability to stimulate angiogenesis have not been identified.
Nofziger-Plank, Donna, Flemming, Steven R.   +1 more
core  

Plexin C1, A Receptor for Semaphorin 7A, Inactivates Cofilin and Is a Potential Tumor Suppressor for Melanoma Progression

, 2009
Melanocytes are progenitor cells for melanoma, which arises through step-wise progression from dysplastic to invasive, to metastatic tumor. Our previous data showed that semaphorin 7A (Sema7A), a protein involved in axon guidance, stimulates melanocyte ...
Scott, Glynis A., Fricke, Alex F., McClelland, Lindy A., Fender, Anne   +3 more
core   +1 more source