Results 171 to 180 of about 7,206 (213)
The Role of Semaphorins in Metabolic Disorders
International Journal of Molecular Sciences, 2020 Semaphorins are a family originally identified as axonal guidance molecules. They are also involved in tumor growth, angiogenesis, immune regulation, as well as other biological and pathological processes.
Qiongyu Lu
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The Involvement of Semaphorins in the Pathogenesis of Skin Diseases
International Journal of Molecular Sciences, 2023 Semaphorins belong to a group of membrane and secretory proteins that act as ligands for several receptor families and are involved in modulating cell signaling pathways. They bind multimeric receptor complexes on the cell membrane to exert their effects
Sylwia Słuczanowska-Głąbowska +2 more
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Class-3 Semaphorins and Their Receptors: Potent Multifunctional Modulators of Tumor Progression
International Journal of Molecular Sciences, 2019 Semaphorins are the products of a large gene family containing 28 genes of which 21 are found in vertebrates. Class-3 semaphorins constitute a subfamily of seven vertebrate semaphorins which differ from the other vertebrate semaphorins in that they are ...
Shira Toledano +2 more
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Semaphorins and Their Roles in Breast Cancer: Implications for Therapy Resistance [PDF]
International Journal of Molecular Sciences, 2023 Breast cancer is the most common cancer worldwide and a leading cause of cancer-related deaths in women. The clinical management of breast cancer is further complicated by the heterogeneous nature of the disease, which results in varying prognoses and ...
Radhika Aiyappa-Maudsley +2 more
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Transmembrane semaphorins: Multimodal signaling cues in development and cancer [PDF]
Cell Adhesion and Migration, 2016 Semaphorins constitute a large family of membrane-bound and secreted proteins that provide guidance cues for axon pathfinding and cell migration. Although initially discovered as repelling cues for axons in nervous system, they have been found to ...
Sreeharsha Gurrapu, Luca Tamagnone
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Role of Semaphorins in Immunopathologies and Rheumatic Diseases
International Journal of Molecular Sciences, 2019 Rheumatic diseases are disorders characterized by joint inflammation, in which other organs are also affected. There are more than two hundred rheumatic diseases, the most studied so far are rheumatoid arthritis, osteoarthritis, spondyloarthritis ...
Samuel Garcia, Garcia Samuel
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The role of the semaphorins in cancer [PDF]
Cell Adhesion and Migration, 2016 The semaphorins were initially characterized as axon guidance factors, but have subsequently been implicated also in the regulation of immune responses, angiogenesis, organ formation, and a variety of additional physiological and developmental functions.
Géra Neufeld +2 more
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Frontiers in Bioscience, 2005
The semaphorins are the products of a large family of genes currently containing more than 30 members. These genes are divided into eight classes of which classes 1, 2 and 8 contain invertebrate and viral semaphorins, while classes 3-7 contain the vertebrate semaphorins.
Gera, Neufeld +5 more
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The semaphorins are the products of a large family of genes currently containing more than 30 members. These genes are divided into eight classes of which classes 1, 2 and 8 contain invertebrate and viral semaphorins, while classes 3-7 contain the vertebrate semaphorins.
Gera, Neufeld +5 more
openaire +2 more sources
Control of semaphorin signaling
Current Opinion in Neurobiology, 2002Receptor complexes for the chemorepellent factors of the semaphorin family activate intracellular pathways that trigger actin rearrangements underlying growth cone collapse and repellent behavior. Some evidence has been provided for a complex and dynamic pattern of interaction between members of the small Rho guanosine triphosphatases and plexin ...
Castellani, Valérie, Rougon, Geneviève
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Osteoprotection by semaphorin 3A
Nature, 2012The bony skeleton is maintained by local factors that regulate bone-forming osteoblasts and bone-resorbing osteoclasts, in addition to hormonal activity. Osteoprotegerin protects bone by inhibiting osteoclastic bone resorption, but no factor has yet been identified as a local determinant of bone mass that regulates both osteoclasts and osteoblasts ...
Mikihito, Hayashi +5 more
openaire +2 more sources