Results 91 to 100 of about 1,805,611 (181)

Effect of Pyridoxamine on Semicarbazide-sensitive Amine Oxidase Activity of Rabbit Lung and Heart

, 1989
Rabbit lung and heart show clorgyline-resistant benzylamine oxidase activity which is sensitive to semicarbazide (SSAO) and α-amino-guanidine. This SSAO activity is inhibited by pyridoxamine with an IC50 of 6·3 × −6 M for lung and of 1·1 × 10−5 M for ...
B Bertocci, L Raimondi, F Buffoni, G Banchelli   +3 more
core   +1 more source

In-vivo Effects of (E)-2-(3′,4′-dimethoxyphenyl)-3-fluoroallylamine (MDL 72145) on Amine Oxidase Activities in the Rat. Selective Inhibition of Semicarbazide-sensitive Amine Oxidase in Vascular and Brown Adipose Tissues

, 1989
One hour after MDL 72145 ((E)-2-(3′,4′-dimethoxyphenyl)-3-fluoroallylamine) (2·5 mg kg−1) was given by intraperitoneal injection, the semicarbazide-sensitive amine oxidase (SSAO) activity of rat aorta and brown adipose tissue measured in-vitro was ...
Jonathan Elliott, Brian A Callingham, Margery A Barrand   +2 more
core   +1 more source

Limitation of adipose tissue enlargement in rats chronically treated with semicarbazide-sensitive amine oxidase and monoamine oxidase inhibitors.

, 2008
International audienceInhibition of semicarbazide-sensitive amine oxidases (SSAO) and monoamine oxidases (MAO) reduces fat deposition in obese rodents: chronic administration of the SSAO-inhibitor semicarbazide (S) in combination with pargyline (MAO ...
Iffiú-Soltész, Zsuzsa, Mercier, Nathalie, Carpéné, Christian, Valet, Philippe, Abello, Veronica, Fève, Bruno   +5 more
core   +1 more source

The first selective VAP-1 inhibitor in China, TT-01025-CL: safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multiple-ascending doses

Frontiers in Pharmacology
Introduction: TT-01025-CL is an oral, irreversible small molecule that potently inhibits vascular adhesion protein-1 (VAP-1) for the treatment of inflammation associated with non-alcoholic steatohepatitis (NASH).
Yuanxun Yang, Lei Yu, Zejuan Sheng, Hui Lin, Zuyi Weng, Wei Song, Bei Cao, Yu Zhao, Yingsheng Gao, Shumao Ni, Huimin Wang, Tingting Ma, Lei Huang, Caixia Sun, Juan Li   +14 more
doaj   +1 more source

Studies of Monoamine Oxidase and Semicarbazide-Sensitive Amine Oxidase

Japanese Journal of Pharmacology, 1986
Yuichiro ARAL, Yoshie TOYOSHIMA, Hiroyasu KINEMUCHI   +2 more
openaire   +4 more sources

Design, Synthesis, and Biological Evaluation of Semicarbazide-Sensitive Amine Oxidase (SSAO) Inhibitors with Anti-inflammatory Activity

, 2016
In an attempt to examine the effect of inhibition of semicarbazide-sensitive amine oxidase (SSAO; EC 1.4.3.6, also known as VAP-1) as a novel anti-inflammatory target, the structure/mechanism based design and synthesis of a series of novel hydrazino ...
Jun Zhang (48506), Matthew D. Linnik (2644744), Andrew Miller (1971958), Jingjing Zhao (129177), Li Huang (107408), Hongfeng Gao (2644756), Luisa Salter-Cid (1429873), Erika M. Podar (2644753), Anne O'Rourk (2644747), Eric Y. Wang (2644750)   +9 more
core   +1 more source

P3.13 ROLE OF THE SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) IN CELL DIFFERENTIATION: CONSEQUENCES IN ATHEROSCLEROSIS

Artery Research, 2012
A. Filip, S. Taleb, F. Fève, J. Magdalou, S. Jalkanen, Z. Mallat, P. Lacolley, N. Mercier   +7 more
doaj   +1 more source

Inhibition of Semicarbazide-sensitive Amine Oxidase Reduces Atherosclerosis in Cholesterol-fed New Zealand White Rabbits. [PDF]

Sci Rep, 2018
Wang SH, Yu TY, Hung CS, Yang CY, Lin MS, Su CY, Chen YL, Kao HL, Chuang LM, Tsai FC, Li HY.   +10 more
europepmc   +1 more source

Biological roles of semicarbazide sensitive amine oxidase

, 2019
TARA (Trinity’s Access to Research Archive) has a robust takedown policy.
openaire   +1 more source

Inhibition of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 reduces lipopolysaccharide-induced neuroinflammation. [PDF]

Br J Pharmacol, 2017
Becchi S, Buson A, Foot J, Jarolimek W, Balleine BW.   +4 more
europepmc   +1 more source