Results 91 to 100 of about 2,006 (201)

Salsolinol: an Unintelligible and Double-Faced Molecule—Lessons Learned from In Vivo and In Vitro Experiments [PDF]

, 2017
Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline) is a tetrahydroisoquinoline derivative whose presence in humans was first detected in the urine of Parkinsonian patients on l-DOPA (l-dihydroxyphenylalanine) medication.
Bugajski, Andrzej, Gil, Krzysztof, Kurnik-Łucka, Magdalena, Panula, Pertti   +3 more
core   +2 more sources

Modulation of Primary Amine Oxidase by Phytochemicals [PDF]

, 2018
Primary Amine Oxidase (PrAO) is an enzyme with a variety of physiological roles. It catalyses the oxidative deamination of primary amines to the corresponding aldehydes. PrAO converts amines such as methylamine and aminoacetone to reactive compounds that
Shanahan, Padraig
core   +1 more source

Theobromine and related methylxanthines as inhibitors of Primary Amine Oxidase [PDF]

, 2018
Methylxanthines are the most widely consumed drugs in the world and evidence of their health benefits has been growing in recent years. Primary Amine Oxidase (PrAO) has been recognised as a therapeutic target for amelioration of inflammatory, vascular ...
Henehan, Gary, Kinsella, Gemma, O’Sullivan, Jeffrey, Ryan, Barry, Shanahan, Padraig, Tipton, Keith   +5 more
core   +1 more source

Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model

Frontiers in Pharmacology
IntroductionMonoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol ...
Ádám István Horváth, Ádám István Horváth, Kata Bölcskei, Nikolett Szentes, Nikolett Szentes, Nikolett Szentes, Éva Borbély, Éva Borbély, Valéria Tékus, Valéria Tékus, Valéria Tékus, Bálint Botz, Kitti Rusznák, Kitti Rusznák, Anett Futácsi, Anett Futácsi, Boldizsár Czéh, Boldizsár Czéh, Péter Mátyus, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes   +23 more
doaj   +1 more source

A Novel MAO-B/SSAO Inhibitor Improves Multiple Aspects of Dystrophic Phenotype in mdx Mice

Antioxidants
Duchenne muscular dystrophy (DMD) is one of the most frequent and severe childhood muscle diseases. Its pathophysiology is multifaceted and still incompletely understood, but we and others have previously shown that oxidative stress plays an important ...
Francesca Gasparella, Leonardo Nogara, Elena Germinario, Lucia Tibaudo, Stefano Ciciliot, Giorgia Piccoli, Francisca Carolina Venegas, Francesca Fontana, Gabriele Sales, Daniele Sabbatini, Jonathan Foot, Wolfgang Jarolimek, Bert Blaauw, Marcella Canton, Libero Vitiello   +14 more
doaj   +1 more source

Semicarbazide-sensitive amine oxidase substrates in obesity and diabetes [PDF]

, 2010
L'obésité et le diabète sont de sérieux problèmes de santé dans les pays développés. Le développement de médicaments qui pourraient normaliser un métabolisme glucidique alteré est donc une grande nécessité actuelle.
Iffiu-Soltész, Zsuzsa
core  

Oxidative deamination of aliphatic amines by rat aorta semicarbazide-sensitive amine oxidase

Journal of Pharmacy and Pharmacology, 1990
AbstractRat aorta semicarbazide-sensitive amine oxidase (SSAO) exhibits very high affinity in the deamination of an homologous series of aliphatic amines of 1 to 18 straight chain carbon atoms. The Km value decreases substantially as the chain length of these amines increases. The Vmax values are higher for the short chain amines.
openaire   +2 more sources

Novel hydrazine molecules as tools to understand the flexibility of vascular adhesion protein-1 ligand-binding site: toward more selective inhibitors [PDF]

, 2011
Fülöp Ferenc, Lázár László, Nurminen Elisa M., Pentikainen Olli T., Pentikainen Ulla, Pihlavisto Marjo   +5 more
core   +1 more source

The examination of Concentration of Cu contained amine oxidase enzyme in dysmenorrhea [PDF]

Background and purpose: Primary dysmenorrhea, in the absence of any specific pelvic disease, is one of the most common complaints in women's medicine. The cause of primary dysmenorrhea is still not well known but prostaglandins play a major role which
اتحاد, غلامحسین, امانی, مجتبی, خیرجویی, نیکو, رحیمی, گیتی   +3 more
core  

Semicarbazide-Sensitive Amine Oxidase Increases in Calcific Aortic Valve Stenosis and Contributes to Valvular Interstitial Cell Calcification. [PDF]

Oxid Med Cell Longev, 2020
Mercier N, Pawelzik SC, Pirault J, Carracedo M, Persson O, Wollensack B, Franco-Cereceda A, Bäck M.   +7 more
europepmc   +1 more source