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Some properties of semicarbazide-sensitive amine oxidases
1987The semicarbazide-sensitive amine oxidases (SSAOs) comprise a substantial but diffuse group of enzymes separable from classical monoamine oxidase in several respects. Differences in cofactor requirement, molecular weight and subcellular distribution are crucial for such a separation.
B A, Callingham, M A, Barrand
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Semicarbazide-Sensitive Amine Oxidase Activity in the Human Heart
Molecular Genetics and Metabolism, 1998A semicarbazide-sensitive amine oxidase with affinity for benzylamine (Bz.SSAO) was found in the human heart. This enzymatic activity has a K(m) of 278 +/- 35.3 microM and a V(m) of 114.7 +/- 14.7 nmol mg-1 min-1 (mean +/- SE of eight hearts) for benzylamine and is strongly inhibited by 1 mM histamine and by B24, a specific inhibitor of Bz.SSAO.
R, Pino, L, Mazzetti, F, Buffoni
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Semicarbazide-sensitive amine oxidase in pig heart
1998A semicarbazide-sensitive amine oxidase (SSAO) (E.C.1.4.3.6) has been purified from pig heart. Western blot analysis showed that the enzyme reacts with a polyclonal antibody raised against homogeneous crystalline pig plasma benzylamine oxidase (BAO). A subunit molecular mass of 97 KDa obtained by SDS electrophoresis is identical to the plasma enzyme ...
T G, Dowling, S, Cambi, F, Buffoni
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Semicarbazide-sensitive amine oxidases in pig dental pulp
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003The behaviour of semicarbazide-sensitive amine oxidase (SSAO; E.C. 1.4.3.6) in dental pulp has been studied, with particular reference to the metabolism of 5-hydroxytryptamine (5-HT; serotonin). Kinetic studies using radioactively labelled substrates have confirmed benzylamine, 2-phenylethylamine (PEA) and 5-HT to be substrates for microsomal SSAO from
Michael, O'Sullivan +4 more
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Semicarbazide-Sensitive Amine Oxidase (SSAO) in the Brain
Neurochemical Research, 2002Semicarbazide-sensitive amine oxidase (SSAO) is widely distributed in almost tissues. However, its presence in brain microvessels is still controversial. The affinity of SSAO towards benzylamine (Bz) is considerably higher than that of monoamine oxidase (MAO). SSAO plays a role in the toxicity of several environmental and endogenous amines.
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Some aspects of the pharmacology of semicarbazide-sensitive amine oxidases
1990Semicarbazide-sensitive amine oxidase enzymes (SSAO) are found in animals, plants, fungi and bacteria. In vertebrates, their distribution in tissues and blood plasma varies between species. Studies of the SSAO enzymes have concentrated on their biochemical identities separate from those of MAO.
B A, Callingham, A, Holt, J, Elliott
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The Journal of Pharmacology and Experimental Therapeutics, 2005
Human semicarbazide-sensitive amine oxidase (SSAO) or vascular adhesion protein-1 (VAP-1) is a copper-containing amine oxidase (AOC3, EC 1.4.3.6) that has both enzymatic and adhesive function. SSAO catalyzes the oxidative deamination of primary amines, resulting in the formation of the corresponding aldehyde and release of hydrogen peroxide and ammonia.
Luisa M, Salter-Cid +7 more
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Human semicarbazide-sensitive amine oxidase (SSAO) or vascular adhesion protein-1 (VAP-1) is a copper-containing amine oxidase (AOC3, EC 1.4.3.6) that has both enzymatic and adhesive function. SSAO catalyzes the oxidative deamination of primary amines, resulting in the formation of the corresponding aldehyde and release of hydrogen peroxide and ammonia.
Luisa M, Salter-Cid +7 more
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Plasma semicarbazide-sensitive amine oxidase in human (patho)physiology
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003Semicarbazide-sensitive amine oxidases (SSAO) are widely distributed enzymes, with as yet not fully elucidated functions and roles, present in many tissues but also circulating in plasma. The enzyme also functions as an adhesion molecule, the vascular adhesion protein-1.
Boomsma, Frans +3 more
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CULTURE MEDIUM ENHANCES SEMICARBAZIDE-SENSITIVE AMINE OXIDASE ACTIVITY
In Vitro Cellular & Developmental Biology - Animal, 2002Components of fetal calf serum (FCS) are known to contribute to growth and maintenance of cultured cells. Fetal calf serum supplementation of media also may contribute to the cytotoxicity of other substances to cells grown in vitro. Semicarbazide-sensitive amine oxidase (SSAO) enzyme, present in FCS, metabolizes primary amines and contributes to amine ...
M B, Trent, D J, Conklin, P J, Boor
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Semicarbazide-sensitive amine oxidase kills African trypanosomes in vitro
Acta Tropica, 2011The African trypanosome Trypanosoma brucei is the cause of sleeping sickness in humans and Nagana in animals. Here we report that semicarbazide-sensitive amine oxidases (SSAOs), enzymes that are abound in T. brucei mammal hosts, eliminate trypanosomes by oxidation of its substrate in vitro. SSAO and its endogenous substrate methylamine are not toxic to
Qiao-Ping, Wang +4 more
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