Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry
ChemistrySelect, Volume 9, Issue 27, July 18, 2024.Oximes are considered as versatile pharmacophores in discovery new class of medicinally active agents. The incorporation of hydroxylamine‐containing moieties to the carbonyl compounds can generate variety oximes. The current review focused on 49 reports, describing about various activities, including antimicrobial, anticancer, anti‐inflammatory ...
Namitha Chandran +13 more
wiley +1 more source
The ROS-generating and antioxidant systems in the liver of rats treated with prednisolone and vitamin D(3) [PDF]
The Ukrainian Biochemical Journal, 2014 The mechanisms of glucocorticoid-induced disturbances of liver function is currently not fully clarified. Vitamin D3 was previously shown to play an important role in the regulation of impaired oxidative metabolism and detoxification function of the ...
I. O. Shymanskyy +5 more
doaj +1 more source
Smooth Muscle-Generated Methylglyoxal Impairs Endothelial Cell-Mediated Vasodilatation of Cerebral Microvessels in Type 1 Diabetic Rats [PDF]
, 2016 Background and Purpose Endothelial cell-mediated vasodilatation of cerebral arterioles is impaired in individuals with Type 1 diabetes (T1D). This defect compromises haemodynamics and can lead to hypoxia, microbleeds, inflammation and exaggerated ...
Alomar, Fadhel +7 more
core +1 more source
Aldolase B knockdown prevents high glucose-induced methylglyoxal overproduction and cellular dysfunction in endothelial cells. [PDF]
PLoS ONE, 2012 We used cultured endothelial cells as a model to examine whether up-regulation of aldolase B and enhanced methylglyoxal (MG) formation play an important role in high glucose-induced overproduction of advanced glycosylation endproducts (AGEs), oxidative ...
Jianghai Liu +5 more
doaj +1 more source
The Dietary Antioxidant Piceatannol Inhibits Adipogenesis of Human Adipose Mesenchymal Stem Cells and Limits Glucose Transport and Lipogenic Activities in Adipocytes [PDF]
, 2018 Phenolic compounds are among the most investigated herbal remedies, as is especially the case for resveratrol. Many reports have shown its anti-aging properties and the ability to reduce obesity and diabetes induced by high-fat diet in mice.
Aguirre, Leixuri +8 more
core +4 more sources
Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies [PDF]
, 2016 The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1389200217666151222155216 © 2018 Bentham Science PublishersBackground: Diabetes mellitus (DM) is a pandemic metabolic ...
Benham, Christopher +3 more
core +4 more sources
A terc-amino effektus vizsgálata és kiterjesztése: új típusú, biológiailag aktív policiklusos vegyületek előállítása = The study and the extension of the tert-amino effect: Synthesis of new types of polycyclic compounds with biological activities [PDF]
, 2013 1. Vizsgáltuk a terc-amino effektus 2. típusának kiterjesztését a reakcióban résztvevő vinil és terc-amino csoportot két külön gyűrűn tartalmazó (kondenzált) bi- és triaril - bifenil/fenilpiridazin, trifenil/difenilpiridazin, naftalin illetve ...
Balogh, Balázs +8 more
core
Vascular Adhesion Protein-1 Blockade Suppresses Ocular Inflammation After Retinal Laser Photocoagulation in Mice [PDF]
, 2017 PURPOSE. To investigate the effect of the vascular adhesion protein-1 (VAP-1) inhibitor RTU-1096 on retinal morphologic changes and ocular inflammation after retinal laser photocoagulation in mice. METHODS. C57BL/6JJcl mice were fed a diet containing RTU-
Ishida, Susumu +6 more
core +1 more source
Resveratrol Anti-Obesity Effects: Rapid Inhibition of Adipocyte Glucose Utilization
Antioxidants, 2019 Studies in animal models of diabetes and obesity have shown that resveratrol mitigates complications of metabolic diseases, beyond those resulting from oxidative stress.
Christian Carpéné +7 more
doaj +1 more source
Rekonstruktion des großen Oecus der Villa des P. Fannius Synistor in Boscoreale [PDF]
, 1975 Semicarbazide-sensitive amine oxidase (SSAO, EC 1.4.3.6) belongs to a family of copper-containing amine oxidases. SSAO exists as a membrane bound protein in endothelial-, smooth muscle-, and adipose cells as well as soluble in plasma.
Andreae, Bernard
core +1 more source