Results 51 to 60 of about 2,006 (201)

Metabolic Effects of Oral Phenelzine Treatment on High-Sucrose-Drinking Mice [PDF]

, 2018
Phenelzine has been suggested to have an antiobesity effect by inhibiting de novo lipogenesis, which led us to investigate the metabolic effects of oral chronic phenelzine treatment in high-sucrose-drinking mice.
Carpéné, Christian, Chaplin, Alice, Gómez Zorita, Saioa, Mercader, Josep   +3 more
core   +2 more sources

Correction: Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model [PDF]

Frontiers in Pharmacology
Ádám István Horváth, Ádám István Horváth, Kata Bölcskei, Nikolett Szentes, Nikolett Szentes, Nikolett Szentes, Éva Borbély, Éva Borbély, Valéria Tékus, Valéria Tékus, Valéria Tékus, Bálint Botz, Kitti Rusznák, Kitti Rusznák, Anett Futácsi, Anett Futácsi, Boldizsár Czéh, Boldizsár Czéh, Péter Mátyus, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes   +23 more
doaj   +2 more sources

High Throughput Approaches to Unravel the Mechanism of Action of a New Vanadium‐Based Compound against Trypanosoma cruzi

Bioinorganic Chemistry and Applications, Volume 2020, Issue 1, 2020., 2020
Treatment for Chagas disease, a parasitosis caused by Trypanosoma cruzi, has always been based on two drugs, nifurtimox and benznidazole, despite the toxic side effects described after prolonged prescription. In this work, we study a new prospective antitrypanosomal drug based on vanadium, here named VIVO(5Brsal)(aminophen). We found a good IC50 value,
M. Florencia Mosquillo, Pablo Smircich, Analía Lima, Sergio A. Gehrke, Gonzalo Scalese, Ignacio Machado, Dinorah Gambino, Beatriz Garat, Leticia Pérez-Díaz, Anastasios Keramidas   +9 more
wiley   +1 more source

Increased atherosclerotic plaque in AOC3 knock-out in ApoE−/− mice and characterization of AOC3 in atherosclerotic human coronary arteries

Frontiers in Cardiovascular Medicine, 2022
IntroductionAmine oxidase copper containing 3 (AOC3) displays adhesion between leukocytes and endothelial cells and enzymatic functions. Given its controversial role in atherogenesis, we proposed to investigate the involvement of AOC3 in the formation of
Anna Filip, Soraya Taleb, Rümeyza Bascetin, Mohammad Jahangiri, Matthieu Bardin, Cindy Lerognon, Bruno Fève, Patrick Lacolley, Sirpa Jalkanen, Nathalie Mercier   +9 more
doaj   +1 more source

Prenatal dietary load of Maillard reaction products combined with postnatal Coca-Cola drinking affects metabolic status of female Wistar rats. [PDF]

, 2015
AIM: To assess the impact of prenatal exposure to Maillard reaction products (MRPs) -rich diet and postnatal Coca-Cola consumption on metabolic status of female rats.
Ivana Koborová, Katarína Janšáková, Katarína Šebeková, Peter Celec, Radana Gurecká, Tamás Tábi, Veronika Somoza, Éva Szökő   +7 more
core   +2 more sources

Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure [PDF]

, 2012
Chronic liver failure leads to hyperammonemia, a central component in the pathogenesis of hepatic encephalopathy (HE); however, a correlation between blood ammonia levels and HE severity remains controversial. It is believed oxidative stress plays a role
Bosoi, Cristina R., Huynh, Jimmy, Jiang, Wenlei, Parent-Robitaille, Christian, Rose, Christopher, Tremblay, Mélanie, Yang, Xiaoling   +6 more
core   +1 more source

Semicarbazide-sensitive amine oxidase / vascular adhesion protein-1 activity exerts an antidiabetic action in Goto-Kakizaki rats [PDF]

, 2023
n this study we have explored whether the bifunctional protein semicarbazide-sensitive amine oxidase (SSAO)/vascular adhesion protein-1 (VAP-1) represents a novel target for type 2 diabetes. To this end, Goto-Kakizaki (GK) diabetic rats were treated with
Abella, Anna, Camps Camprubí, Marta, Carpene, Christian, Claret i Carles, Marc, Fernández-Álvarez, Joaquin, Gomis, Ramon, Gumà i Garcia, Anna Maria, Marti, Luc, Palacín Prieto, Manuel, Testar, Xavier, Viguerie, Nathalie, Zorzano Olarte, Antonio   +11 more
core   +1 more source

A review of antioxidant and pharmacological properties of phenolic compounds in Acacia confusa

Journal of Traditional and Complementary Medicine, 2018
In the present review article, the phytochemical, antioxidant and pharmacological studies are congregated and summarized concerning the current knowledge of the phenolic compounds of a traditional medical plant Acacia confusa in Taiwan.
Huan-You Lin, Tzu-Cheng Chang, Shang-Tzen Chang   +2 more
doaj   +1 more source

Precision medicine in diabetes prediction: Exploring a subgroup‐specific biomarker strategy for risk stratification

Journal of Diabetes Investigation, Volume 16, Issue 1, Page 43-50, January 2025.
This study from the Taiwan Lifestyle Cohort uses subgroup‐specific biomarkers for precision type 2 diabetes prediction. We found that a gender‐ and BMI‐specific biomarker strategy, which used blood SCG3 and VAP‐1 levels in different subgroups, can improve the prediction of incident diabetes.
I‐Weng Yen, Szu‐Chi Chen, Chia‐Hung Lin, Kang‐Chih Fan, Chung‐Yi Yang, Chih‐Yao Hsu, Chun‐Heng Kuo, Mao‐Shin Lin, Ya‐Pin Lyu, Hsien‐Chia Juan, Lin Heng‐Huei, Hung‐Yuan Li   +11 more
wiley   +1 more source

Functional modulation of vascular adhesion protein-1 by a novel splice variant. [PDF]

PLoS ONE, 2013
Vascular Adhesion Protein-1 (VAP-1) is an endothelial adhesion molecule belonging to the primary amine oxidases. Upon inflammation it takes part in the leukocyte extravasation cascade facilitating transmigration of leukocytes into the inflamed tissue ...
Sam Kaitaniemi, Kirsi Grön, Heli Elovaara, Marko Salmi, Sirpa Jalkanen, Kati Elima   +5 more
doaj   +1 more source