Results 31 to 40 of about 2,006 (201)

Lysyl Oxidases as Targets for Cancer Therapy and Diagnostic Imaging

ChemMedChem, Volume 18, Issue 18, September 15, 2023., 2023
Over the past two decades, lysyl oxidases have been recognised as key enzymes in tumour invasion and metastasis, which has spurred efforts to develop inhibitors and molecular probes for therapeutic and imaging purposes, respectively. This review summarises the structural and functional aspects of these unique enzymes in relation to tumour progression ...
Reik Löser, Manuela Kuchar, Robert Wodtke, Christin Neuber, Birgit Belter, Klaus Kopka, Lakshmi Santhanam, Jens Pietzsch   +7 more
wiley   +1 more source

Association between plasma activities of semicarbazide-sensitive amine oxidase and angiotensin-converting enzyme in patients with type 1 diabetes mellitus [PDF]

, 2005
Aims/hypothesis: Plasma semicarbazide-sensitive amine oxidase (SSAO) is elevated in patients with type 1 and type 2 diabetes and has been implicated in the pathophysiology of diabetic late complications. The regulation of SSAO production remains unknown.
Agerholm-Larsen, B. (B.), Boomsma, F. (Frans), Dhamrait, S.S. (S.), Hut, H., Meiracker, A.H. (Anton) van den, Pedersen-Bjergaard, U. (Ullrik), Thorsteinsson, B. (Birger)   +6 more
core   +5 more sources

Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: “Always‐On” and “Turn‐On” Probes

Advanced Science, Volume 9, Issue 25, September 5, 2022., 2022
Photoacoustic imaging is a nonionizing, noninvasive imaging technique that combines optical and ultrasonic imaging modalities to provide images with excellent contrast, spatial resolution, and penetration depth. Exogenous photoacoustic contrast agents are created to increase its sensitivity and specificity to offer diagnostic information.
Yun Zeng, Taotao Dou, Lei Ma, Jingwen Ma
wiley   +1 more source

Recent advances in nanomaterial‐assisted electrochemical sensors for food safety analysis

Food Frontiers, Volume 3, Issue 3, Page 453-479, September 2022., 2022
This review focuses on current research achievements of nanomaterial‐assisted electrochemical sensors for food safety analysis reported in recent years. It highlights the different detection mechanisms for analytes, flexible sensing strategies based on nanomaterials, and portable miniaturized electrochemical devices.
Ying Gu, Yonghui Li, Dabing Ren, Liping Sun, Yongliang Zhuang, Lunzhao Yi, Shuo Wang   +6 more
wiley   +1 more source

ω‐(5‐Phenyl‐2H‐tetrazol‐2‐yl)alkyl‐substituted hydrazides and related compounds as inhibitors of amine oxidase copper containing 3 (AOC3)

Archiv der Pharmazie, Volume 355, Issue 8, August 2022., 2022
Inhibitors of amine oxidase copper containing 3 (AOC3) could be created by replacement of the amine functionality of the tight‐binding substrate 6‐(5‐phenyl‐2H‐tetrazol‐2‐yl)hexan‐1‐amine (1) by hydrazide, glycine amide, and structurally related moieties.
Florian Galster, Timo Pöstges, Walburga Hanekamp, Matthias Lehr   +3 more
wiley   +1 more source

Allosteric modulation of semicarbazide-sensitive amine oxidase activities in vitro by imidazoline receptor ligands [PDF]

British Journal of Pharmacology, 2004
Andrew Holt, Glen B Baker
exaly   +2 more sources

Acute high‐altitude hypoxia exposure causes neurological deficits via formaldehyde accumulation

CNS Neuroscience &Therapeutics, Volume 28, Issue 8, Page 1183-1194, August 2022., 2022
Proposed molecular mechanism of acute hypobaric hypoxia induced neurological deficits via formaldehyde accumulation. AHH, acute hypobaric hypoxia; MA, methylamine; SSAO, semicarbazide‐sensitive amine oxidase; FA, formaldehyde; ALDH2, aldehyde dehydrogenase 2; H2O, water; CO2, carbon dioxide; GSH, glutathione; GPx4, glutathione peroxidase 4; LPO, lipid ...
Xiaoyin Wang, Haochen Sun, Lili Cui, Xian Wang, Changhong Ren, Zhiqian Tong, Xunming Ji   +6 more
wiley   +1 more source

Single‐cell transcriptional profiling of human carotid plaques reveals a subpopulation of endothelial cells associated with stroke incidences

Journal of Cellular and Molecular Medicine, Volume 26, Issue 12, Page 3446-3459, June 2022., 2022
Abstract The differences in plaque histology between symptomatic and asymptomatic patients have been widely accepted. Whether there is a heterogeneity of cells between symptomatic and asymptomatic plaques remains largely unclear. To reveal the potential heterogeneity within different plaques, which may contribute to different stroke incidences, we ...
Fengchan Li, Yun Du, Lei Hong, Ziting Liu, Kunmin Yan, Chu Liu, Zhen Zhu, Qiongyu Lu, Chaojun Tang, Li Zhu   +9 more
wiley   +1 more source

Presence of nitrofurans and their metabolites in gelatine

EFSA Journal, Volume 19, Issue 10, October 2021., 2021
Abstract Following the detection of semicarbazide (SEM) in gelatine by Italian Authorities, at levels exceeding by three times the reference point for action (RPA) of 1 μg/kg, set out by Commission Regulation (EU) 2019/1871 for nitrofurans and their metabolites, the European Commission mandated EFSA to investigate the available sources of nitrofurans ...
European Food Safety Authority (EFSA), Michael O'Keeffe, Anna Christodoulidou, Carlo Nebbia   +3 more
wiley   +1 more source

The cellular function and molecular mechanism of formaldehyde in cardiovascular disease and heart development

Journal of Cellular and Molecular Medicine, Volume 25, Issue 12, Page 5358-5371, June 2021., 2021
Abstract As a common air pollutant, formaldehyde is widely present in nature, industrial production and consumer products. Endogenous formaldehyde is mainly produced through the oxidative deamination of methylamine catalysed by semicarbazide‐sensitive amine oxidase (SSAO) and is ubiquitous in human body fluids, tissues and cells.
Ying Zhang, Yanyan Yang, Xiangqin He, Panyu Yang, Tingyu Zong, Pin Sun, Rui‐cong Sun, Tao Yu, Zhirong Jiang   +8 more
wiley   +1 more source